Results 71 to 80 of about 99,790 (252)

Serum Hsa_circ_0023919 is a Predictive Biomarker of Chemoresistance in CRC Treatment [PDF]

Lei Zhang,1 Chuanfa Fang,1 Weiquan Zhu,1 Wu Zhong,1 Rongqiang Ye2 1Department of Gastrointestinal Hernia, Ganzhou People’s Hospital, Ganzhou, Jiangxi, 341000, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, Ganzhou People’
Ye R, Zhong W, Fang C, Zhang L, Zhu W
core  

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Identification of potential chemoresistance genes in osteosarcoma

, 2008
BACKGROUND: Osteosarcoma (OS) is an aggressive bone malignancy that primarily affects children and adolescents. Patients with metastatic disease at diagnosis have only a 20% survival rate.
Schmutz, S, Born, W, Fuchs, B, Langsam, B, Steinmann, P, Walters, D K   +5 more
core   +1 more source

Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer [PDF]

, 2015
Background: Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased cellular proliferation ...
Sharon A. O’Toole, Cara M. Martin, GALLAGHER, MICHAEL, Orla Sheils, Lynda M. McEvoy, Cathy D. Spillane, Michael F. Gallagher, Gordon Blackshields, John J. O’Leary, O\u27LEARY, JOHN, SHEILS, ORLA, SPILLANE, CATHY, Britta Stordal   +12 more
core   +4 more sources

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding [PDF]

Advanced science
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Kumari R, Fang J.
europepmc   +2 more sources

Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles

, 2018
Zhe Chen,1,* Yuanqiang Zheng,1,* Yanchun Shi,1 Zhengrong Cui1,2 1Inner Mongolia Key Lab of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China; 2Division of Molecular Pharmaceutics and ...
Zheng Y, Chen Z, Cui Z, Shi Y
core  

Chemoresistance in human ovarian cancer: the role of apoptotic regulators [PDF]

, 2003
Ovarian cancer is among the most lethal of all malignancies in women. While chemotherapy is the preferred treatment modality, chemoresistance severely limits treatment success.
Yan Xiaojuan, Fraser Michael, Arezu Jahani-Asl, Jahani-Asl, Arezu, Jahani-Asl Arezu, Leung Brendan, Winston E Thompson, Yan, Xiaojuan, Xiaojuan Yan, Tsang, Benjamin K, Brendan Leung, Tsang Benjamin K, Benjamin K Tsang, Michael Fraser, Fraser, Michael, Leung, Brendan, Thompson, Winston E, Thompson Winston E   +17 more
core   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesisResearch in context

EBioMedicine, 2019
Background: Chemoresistance is the major cause of neoadjuvant treatment failure in breast cancer patients. Despite recent progress, the mechanism underlying chemoresistance remains to be further defined.
Xue Wang, Songbing He, Yuting Gu, Qiwei Wang, Xiao Chu, Min Jin, Liang Xu, Qiong Wu, Qianjun Zhou, Bei Wang, Yanyun Zhang, Hui Wang, Leizhen Zheng   +12 more
doaj   +1 more source