Results 61 to 70 of about 78,175 (168)

CYP19A1 regulates chemoresistance in colorectal cancer through modulation of estrogen biosynthesis and mitochondrial function

Cancer & Metabolism
Chemoresistance remains a major challenge in the effective treatment of colorectal cancer (CRC), contributing to poor patient outcomes. While the molecular mechanisms underlying chemoresistance are complex and multifaceted, emerging evidence suggests ...
Yang Wang, Qiang Ji, Ning Cao, Guijie Ge, Xiaomin Li, Xiangdong Liu, Yanqi Mi   +6 more
doaj   +1 more source

Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling

Journal for ImmunoTherapy of Cancer, 2019
Background Colorectal cancer (CRC) is one of the most common forms of cancer worldwide. The tumor microenvironment plays a key role in promoting the occurrence of chemoresistance in solid cancers. Effective targets to overcome resistance are necessary to
Dan Wang, Li Yang, Weina Yu, Qian Wu, Jingyao Lian, Feng Li, Shasha Liu, Aitian Li, Zhiang He, Jinbo Liu, Zhenqiang Sun, Weitang Yuan, Yi Zhang   +12 more
doaj   +1 more source

New compositions for the treatment of chemoresistant and/or potentially chemoresistant leukaemias

, 2009
SOMMARIO DELL'INVENZIONE L'invenzione della presente descrizione si basa sulla scoperta che la chemioresistenza in numerose forme leucemiche è eliminata o fortemente ridotta da un trattamento con almeno un composto per terapie antitumorali in combinazione con almeno un bloccante del canale di potassio hERG1.
ARCANGELI, ANNAROSA, Becchetti A., PILLOZZI, SERENA, MASSELLI, MARIKA, DE LORENZO, EMANUELE   +4 more
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Pancreatic cancer- mechanisms of chemoresistance

Postępy Higieny i Medycyny Doświadczalnej, 2016
Despite the enormous progress made over the past decades in diagnosis, treatment and prevention of many types of tumor, the survival rate for pancreatic cancer still remains poor. Pancreatic cancer is one of the most malignant and chemotherapy-resistant tumors. That is mainly due to the lack of effective diagnosis at an early stage of tumor development
openaire   +2 more sources

USP29 and SMURF1 orchestrate FSP1-mediated ferroptosis suppression to facilitate chemoresistance in gastric cancer

Nature Communications
Gastric cancer (GC) ranks as the third leading cause of cancer-related mortality. Chemoresistance poses a major obstacle to successful treatment for GC patients. Here, we demonstrate that ferroptosis suppressor protein 1 (FSP1) enables chemoresistance in
Zheming Wu, Xinyi Tu, Shouhai Zhu, Qi Jiang, Liewei Wang, Kaixiong Tao, Zhenkun Lou, Min Deng, Xiangyu Zeng   +8 more
doaj   +1 more source

MBD2 regulates the progression and chemoresistance of cholangiocarcinoma through interaction with WDR5

Journal of Experimental & Clinical Cancer Research
Background Cholangiocarcinoma (CCA) is a highly malignant, rapidly progressing tumor of the bile duct. Owing to its chemoresistance, it always has an extremely poor prognosis.
Da Wang, Junsheng Chen, Guanhua Wu, Fei Xiong, Wenzheng Liu, Qi Wang, Yiyang Kuai, Wenhua Huang, Yongqiang Qi, Bing Wang, Ruizhi He, Yongjun Chen   +11 more
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PFKM promotes chemoresistance in lung adenocarcinoma by regulating RAB8B mediated exosome release

Journal of Pharmaceutical Analysis
Lung adenocarcinoma (LUAD), the most widely existing subtype of non-small cell lung cancer (NSCLC), is a leading cause of cancer-related mortality, characterized by challenging early diagnosis, high rates of recurrence and metastasis, and poor prognosis.
Qiang Wang, Qiyao Nong, Junguo Zang, Meiyu Gao, Ying Zhang, Xinyuan Hao, Yuan Tian, Fengguo Xu, Pei Zhang   +8 more
doaj   +1 more source

UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SLC7A11 signaling

Redox Biology
Chemoresistance remains a principal culprit for the treatment failure in colorectal cancer (CRC), especially for patients with recurrent or metastatic disease.
Mei Song, Shuting Huang, Xiaoxue Wu, Ziyi Zhao, Xiaoting Liu, Chong Wu, Mengru Wang, Jialing Gao, Zunfu Ke, Xiaojing Ma, Weiling He   +10 more
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NGR‐Modified CAF‐Derived exos Targeting Tumor Vasculature to Induce Ferroptosis and Overcome Chemoresistance in Osteosarcoma

Advanced Science
Osteosarcoma (OS) chemoresistance presents a significant clinical challenge. This study aims to investigate the potential of using tumor vascular‐targeting peptide NGR‐modified cancer‐associated fibroblasts (CAFs)‐derived exosomes (exos) to deliver ...
Jianxin Du, Xiangwei Meng, Minghao Yang, Guancheng Chen, Jigang Li, Zengjun Zhu, Xuanxuan Wu, Wei Hu, Maojin Tian, Tao Li, Shuai Ren, Peiqing Zhao   +11 more
doaj   +1 more source

Therapeutic targeting potential of the protein lysine and arginine methyltransferases to reverse cancer chemoresistance

Frontiers in Molecular Biosciences
Cancer treatments have continued to improve tremendously over the past decade, but therapy resistance is still a common, major factor encountered by patients diagnosed with cancer.
Isaac Micallef, Isaac Micallef, Kimberly Fenech, Byron Baron   +3 more
doaj   +1 more source