Results 81 to 90 of about 136,885 (362)
Journal of Experimental & Clinical Cancer ResearchThe chemotherapy resistance is an awkward challenge in management of bladder cancer (BC). Cancer organoid model is an effective preclinical tumor model that could faithfully represent clinical manifestations and simulate the biological processes of ...
Yonghao Zhan +6 more
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TMIC-76. HUMANIN RELEASE FROM TUMOR ASSOCIATED MYELOID CELLS PROMOTES GLIOMA CHEMORESISTANCE [PDF]
, 2022 Jiying Cheng +7 more
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Cancer chemoresistance and BAK
Oncoscience, 2015 Blocking or evading apoptosis is one of the hallmarks of cancer [1]. Recent advances in genomic sequencing have identified many mutations in cancer cells, prompting an increased effort to identify driver mutations in critical pathways that impact upon cell survival. Interestingly though, many cancers have intact apoptotic machinery where mutation rates
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FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Warburg effect and lactylation in cancer: mechanisms for chemoresistance
Molecular MedicineIn the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding the mechanisms of chemoresistance is essential for developing effective therapeutic
Wenjie Zhang +6 more
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MiR-193a regulates chemoresistance of human osteosarcoma cells via repression of IRS2
Journal of Bone Oncology, 2019 Chemoresistance prevents curative potential of chemotherapy in most cases. MicroRNAs (miRNAs) are key players in regulating chemoresistance in osteosarcoma, which is the most common primary bone cancer. Bisulfite sequencing and quantitative real time PCR
Haiyan Wang +3 more
doaj +1 more source
The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours [PDF]
, 2014 Primary liver tumours have a high incidence and mortality. The most important forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver progenitor cells
Bogaerts, Eliene +4 more
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FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Neoplasia: An International Journal for Oncology ResearchChemoresistance is one of the major causes of the failure in gastric cancer (GC) treatment and leads to poor clinical outcomes. Ten-eleven translocation (TET) 2 expression and activity are frequently reduced in solid tumors.
Yan Guo +9 more
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