Results 91 to 100 of about 99,790 (252)

CYP19A1 regulates chemoresistance in colorectal cancer through modulation of estrogen biosynthesis and mitochondrial function

Cancer & Metabolism
Chemoresistance remains a major challenge in the effective treatment of colorectal cancer (CRC), contributing to poor patient outcomes. While the molecular mechanisms underlying chemoresistance are complex and multifaceted, emerging evidence suggests ...
Yang Wang, Qiang Ji, Ning Cao, Guijie Ge, Xiaomin Li, Xiangdong Liu, Yanqi Mi   +6 more
doaj   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Mechanisms Underlying Chemoresistance of Choriocarcinoma Investigated with NMR-Based Metabonomics

Chinese Journal of Magnetic Resonance, 2019
Choriocarcinoma (CC) is a malignant trophoblastic tumor that occurs in women of childbearing age. Its cure rate could be over 90% following single drug or multidrug chemotherapy with methotrexate, 5-fluorouracil and etc. Chemoresistance is the main cause
DING Lai-feng, ZHANG Cong-cong, HU Qing-yu, Olivier E. PARDO, Michael J. SECKL, WANG Yu-lan, WU Jun-fang   +6 more
doaj   +1 more source

TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53

, 2016
Yinxiang Lv,1,* Yanan Huo,2,* Xican Yu,1 Rongrong Liu,3 Shufen Zhang,3 Xiaoxiao Zheng,3 Xianning Zhang 3 1Department of Oncology, Xinchang People’s Hospital, Shaoxing, 2Eye Centre, Second Affiliated Hospital of Zhejiang University, School of ...
Zheng X, Huo Y, Lv Y, Zhang X, Liu R, Zhang S, Yu X   +6 more
core  

Pancreatic Cancer Chemoresistance to Gemcitabine

, 2017
Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, ranks among the leading causes of cancer-related deaths in the Western world due to disease presentation at an advanced stage, early metastasis and generally a very ...
Ivar Gladhaug, Manoj Amrutkar
core   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Chemotherapy resistance and risk stratification in gestational trophoblastic neoplasia: A systematic review and network meta-analysis. [PDF]

Acta Obstet Gynecol Scand
Higher pretreatment β‐hCG, greater tumor burden, higher FIGO stage/score, and choriocarcinoma were associated with higher chemoresistance risk in gestational trophoblastic neoplasia. In exploratory network analyses, etoposide‐containing regimens showed lower predicted chemoresistance.
Xue YY, Yang XY, Chen FY, Yang HT, Zhang C, Yan JZ, Wu SS, Wang L.   +7 more
europepmc   +2 more sources

Targeting mitophagy to overcome chemoresistance in ovarian and brain cancers

, 2022
In Oncology, chemoresistance is often responsible for therapeutic failure. In this work where we used human cancer models, we investigated whether precise metabolic changes could account for chemoresistance. Not only in cisplatin-resistant ovarian cancer
Zampieri, Luca
core  

The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells [PDF]

, 2008
Cancer cells acquire drug resistance as a result of selection pressure dictated by unfavorable microenvironments. This survival process is facilitated through efficient control of oxidative stress originating from mitochondria that typically initiates ...
Mark, N.M., S. C. Robson, Baffy, G, N. M. Mark, J. R. Wands, Wands, J.R., Z. Derdak, Beldi, G, G. Beldi, Robson, S.C., G. Baffy, Derdak, Z   +11 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source