Results 31 to 40 of about 99,790 (252)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours.

PLoS ONE, 2008
BackgroundThe microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance ...
Arash Rafii, Pejman Mirshahi, Mary Poupot, Anne-Marie Faussat, Anne Simon, Elodie Ducros, Eliane Mery, Bettina Couderc, Raphael Lis, Jerome Capdet, Julie Bergalet, Denis Querleu, Francoise Dagonnet, Jean-Jacques Fournié, Jean-Pierre Marie, Eric Pujade-Lauraine, Gilles Favre, Jeanine Soria, Massoud Mirshahi   +18 more
doaj   +1 more source

Early Mechanisms of Chemoresistance in Retinoblastoma

, 2022
Retinoblastoma is the most common eye cancer in children and is fatal if left untreated. Over the past three decades, chemotherapy has become the mainstay of eye-sparing treatment.
Kalahasty, Karthik, Ryan A. Gallo, Karthik Kalahasty, Dawn A. Owens, Kurtenbach, Stefan, Anthony M. Cruz, Gallo, Ryan A., Cruz, Anthony M., Daniel Pelaez, Pelaez, Daniel, Owens, Dawn A, Correa, Zelia M., Jeffim N. Kuznetsoff, Kuznetsoff, Jeffim N., Harbour, J. William, Kuznetsoff, Jeffim N, Harbour, J William, Michelle G. Zhang, Owens, Dawn A., Correa, Zelia M, Stefan Kurtenbach, Zhang, Michelle G., Cruz, Anthony M, Zhang, Michelle G, Zelia M. Correa, Gallo, Ryan A, J. William Harbour   +26 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

HMGB1 promotes chemoresistance in small cell lung cancer by inducing PARP1-related nucleophagy

Journal of Advanced Research
Introduction: Small cell lung cancer (SCLC) is prone to chemoresistance, which is closely related to genome homeostasis-related processes, such as DNA damage and repair.
Weitao Shen, Qiong Lyu, Ruibin Yi, Yueqin Sun, Wei Zhang, Ting Wei, Yueming Zhang, Jian Shi, Jian Zhang   +8 more
doaj   +1 more source

Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance

Chinese Journal of Cancer, 2016
Background Osteosarcoma is the most common bone malignancy in children and adolescents, and 20%–30% of the patients suffer from poor prognosis because of individual chemoresistance.
Dong-Yu Wang, Ya-Nan Wu, Jun-Qi Huang, Wei Wang, Meng Xu, Jin-Peng Jia, Gang Han, Bei-Bei Mao, Wen-Zhi Bi   +8 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

FOXD3 confers chemo-sensitivity in ovarian cancer through a miR-335/DAAM1/myosin II axis-dependent mechanism

Journal of Ovarian Research, 2023
Background Chemotherapy is among the most common treatment methods for ovarian cancer (OC). However, chemoresistance limits the effectiveness of chemotherapy and leads to treatment failure.
Shufen Wang, Yan Ma, Yi Hu, Xia Zhao, Yilin Li, Shuming Ouyang, Guifang Luo   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source