Results 31 to 40 of about 78,175 (168)

Insights into Chemoresistance of Prostate Cancer [PDF]

International Journal of Biological Sciences, 2015
Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed.
Zhang, Wei, Meng, Yan, Liu, Na, Wen, Xiao-Fei, Yang, Tao   +4 more
openaire   +2 more sources

HMGB1 promotes chemoresistance in small cell lung cancer by inducing PARP1-related nucleophagy

Journal of Advanced Research
Introduction: Small cell lung cancer (SCLC) is prone to chemoresistance, which is closely related to genome homeostasis-related processes, such as DNA damage and repair.
Weitao Shen, Qiong Lyu, Ruibin Yi, Yueqin Sun, Wei Zhang, Ting Wei, Yueming Zhang, Jian Shi, Jian Zhang   +8 more
doaj   +1 more source

Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours.

PLoS ONE, 2008
BackgroundThe microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance ...
Arash Rafii, Pejman Mirshahi, Mary Poupot, Anne-Marie Faussat, Anne Simon, Elodie Ducros, Eliane Mery, Bettina Couderc, Raphael Lis, Jerome Capdet, Julie Bergalet, Denis Querleu, Francoise Dagonnet, Jean-Jacques Fournié, Jean-Pierre Marie, Eric Pujade-Lauraine, Gilles Favre, Jeanine Soria, Massoud Mirshahi   +18 more
doaj   +1 more source

Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance

Chinese Journal of Cancer, 2016
Background Osteosarcoma is the most common bone malignancy in children and adolescents, and 20%–30% of the patients suffer from poor prognosis because of individual chemoresistance.
Dong-Yu Wang, Ya-Nan Wu, Jun-Qi Huang, Wei Wang, Meng Xu, Jin-Peng Jia, Gang Han, Bei-Bei Mao, Wen-Zhi Bi   +8 more
doaj   +1 more source

Controlling secretion to limit chemoresistance [PDF]

Genes & Development, 2016
The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue of Genes & Development, Bent and colleagues (pp. 1811–1821) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
openaire   +3 more sources

FOXD3 confers chemo-sensitivity in ovarian cancer through a miR-335/DAAM1/myosin II axis-dependent mechanism

Journal of Ovarian Research, 2023
Background Chemotherapy is among the most common treatment methods for ovarian cancer (OC). However, chemoresistance limits the effectiveness of chemotherapy and leads to treatment failure.
Shufen Wang, Yan Ma, Yi Hu, Xia Zhao, Yilin Li, Shuming Ouyang, Guifang Luo   +6 more
doaj   +1 more source

Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis

Cell Death and Disease
Colorectal cancer stem cells (CCSCs) play a critical role in mediating chemoresistance. Lactylation is a post-translational modification induced by lactate that regulates gene expression.
Jiao Deng, Yangkun Li, Lanlan Yin, Shuang Liu, Yanqi Li, Wancheng Liao, Lei Mu, Xuelai Luo, Jichao Qin   +8 more
doaj   +1 more source

Tumor chemosensitivity and chemoresistance assays [PDF]

Cancer, 1996
Chemosensitivity and chemoresistance assays have been used to select potentially more effective chemotherapy regimens and to avoid the toxicity of potentially ineffective drugs.Literature review was conducted.The relevant outcome measure for chemosensitivity assays is improved patient survival.
E, Brown, M, Markman
openaire   +2 more sources

Analysis of chemoresistance characteristics and prognostic relevance of postoperative gemcitabine adjuvant chemotherapy in pancreatic cancer

Cancer Medicine
Aim To investigate the relationship between chemoresistance in pancreatic cancer patients receiving postoperative gemcitabine adjuvant therapy and specific clinical/pathological characteristics, as well as its impact on patient prognosis.
Jiaqiang Ren, Shuai Wu, Tong Su, Jiachun Ding, Fan Chen, Jie Li, Zheng Wang, Liang Han, Zheng Wu   +8 more
doaj   +1 more source

miR-374a-5p: A New Target for Diagnosis and Drug Resistance Therapy in Gastric Cancer

Molecular Therapy: Nucleic Acids, 2019
Chemoresistance is one of the causes associated with poor prognosis in gastric cancer. MicroRNAs (miRNAs) are important regulators of chemoresistance. Exosome-mediated delivery of anti-cancer molecules and drugs have emerged as a new approach for cancer ...
Runbi Ji, Xu Zhang, Hongbing Gu, Jichun Ma, Xiangmei Wen, Jingdong Zhou, Hui Qian, Wenrong Xu, Jun Qian, Jiang Lin   +9 more
doaj   +1 more source