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Effects of Exosomal Viral Components on the Tumor Microenvironment
, 2022 SIMPLE SUMMARY: Oncogenic viral infection may lead to cancers, such as nasopharyngeal carcinoma, hepatocellular carcinoma, and cervical cancer. In addition to the tumor cells themselves, the tumor microenvironment also plays a decisive role in tumor ...
Jing Li +5 more
core +1 more source
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the related genes that play a key regulatory role in cisplatin resistance in lung adenocarcinoma. Methods Bioinformatics methods were used to download the differentially-expressed genes between cisplatin sensitive group and drug ...
WANG Lin +5 more
doaj +1 more source
Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma
, 2022 Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies.
Christine Alewine +7 more
core +1 more source
Telocytes in the Tumor Microenvironment
, 2021 There are several theories explaining the communication between cells in the context of tumor development. Over the years, interactions between normal and transformed cells have been observed. Generally, all types of cells make equal contributions to the formation of the tumor microenvironment - a location of primary oncogenesis.
Aleksandrovych, Veronika, Gil, Krzysztof
openaire +3 more sources
The emerging roles of MAPK-AMPK in ferroptosis regulatory network
Cell Communication and Signaling, 2023 Ferroptosis, a newform of programmed cell death, driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes and is extremely dependent on iron ions, which is differs characteristics from traditional cell ...
Xinyue Wang +4 more
doaj +1 more source
Engineering the tumor microenvironment of colorectal cancer [PDF]
, 2014 The tumor microenvironment contributes significantly to the clinical prognosis, especially in CRC. Infiltration by cells from the adaptive immune system (e.g. CD8) has been linked to a better survival independently of TNM-stage.
Hirt, Christian Kurt
core +1 more source
The Breast Tumor Microenvironment: A Key Player in Metastatic Spread
, 2021 The tumor microenvironment plays a pivotal role in the tumorigenesis, progression, and metastatic spread of many cancers including breast. There is now increasing evidence to support the observations that a bidirectional interplay between breast cancer ...
Barbara E. Nickel +7 more
core +1 more source
Senescent Stromal Cells in the Tumor Microenvironment: Victims or Accomplices?
, 2023 Cellular senescence is a unique cellular state. Senescent cells enter a non-proliferative phase, and the cell cycle is arrested. However, senescence is essentially an active cellular phenotype, with senescent cells affecting themselves and neighboring ...
Minghan Ye +3 more
core +1 more source
Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination
, 2021 The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in therapies targeting the tumor microenvironment.
George S. Karagiannis +5 more
core +1 more source
Firing up the cold tumors by targeting Vps34
OncoImmunology, 2020 Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji +4 more
doaj +1 more source