The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment [PDF]
, 2022 SIMPLE SUMMARY: Tumor microenvironment is a complex and dynamically changing entity, which is crucial for tumor development. Indoleamine 2, 3-dioxygenase 1 is elevated in the tumor microenvironment and is strongly associated with tumor histological ...
Xiaobo Wang +7 more
core +1 more source
Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice [PDF]
, 2023 Cancer immunotherapy has brought significant clinical benefits to numerous patients with malignant disease. However, only a fraction of patients experiences complete and durable responses to currently available immunotherapies.
Dietmar Herndler-Brandstetter +2 more
core +1 more source
The importance of the tumor microenvironment to understand tumor origin, evolution, and treatment response [PDF]
, 2022 During the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets.
Ignacio Ochoa Garrido +3 more
core +1 more source
The Landscape and Clinical Application of the Tumor Microenvironment in Gastroenteropancreatic Neuroendocrine Neoplasms [PDF]
, 2022 SIMPLE SUMMARY: The tumor microenvironment (TME) plays a role in promoting tumor progression. Elucidating the relationship between the TME and tumor cells will benefit current therapies.
Chen, Ruyin +9 more
core +1 more source
Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment [PDF]
, 2021 Despite multimodal treatment, survival chances for high-risk neuroblastoma patients remain poor. Immunotherapeutic approaches focusing on the activation and/or modification of host immunity for eliminating tumor cells, such as chimeric antigen receptor ...
Leontari, Ilia +5 more
core +1 more source
Telocytes in the Tumor Microenvironment
, 2021 There are several theories explaining the communication between cells in the context of tumor development. Over the years, interactions between normal and transformed cells have been observed. Generally, all types of cells make equal contributions to the formation of the tumor microenvironment - a location of primary oncogenesis.
Aleksandrovych, Veronika, Gil, Krzysztof
openaire +3 more sources
DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment [PDF]
, 2021 Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by genomic instability. MM cells present various forms of genetic instability, including chromosomal instability, microsatellite instability, and base-pair alterations, as well as
Takayuki Saitoh, Tsukasa Oda
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Review of the Tumor Microenvironment in Basal and Squamous Cell Carcinoma [PDF]
, 2023 It is widely known that tumor cells of basal and squamous cell carcinoma interact with the cellular and acellular components of the tumor microenvironment to promote tumor growth and progression. While this environment differs for basal and squamous cell
Stafford, Haleigh +15 more
core +2 more sources
Engineering the tumor microenvironment of colorectal cancer [PDF]
, 2014 The tumor microenvironment contributes significantly to the clinical prognosis, especially in CRC. Infiltration by cells from the adaptive immune system (e.g. CD8) has been linked to a better survival independently of TNM-stage.
Hirt, Christian Kurt
core +1 more source
The Role of Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity [PDF]
, 2022 SIMPLE SUMMARY: Tumor associated macrophages (TAMs) support disease progression by providing tumor cells cytokines and chemokines necessary for malignant growth and nutrient support. In the tumor microenvironment (TME), TAMs often rewire their metabolism
Md Nabiul Hasan +7 more
core +1 more source