Results 21 to 30 of about 1,719,424 (316)

Pericytes in the tumor microenvironment

Cancer Letters, 2023
Pericytes are a type of mural cell located between the endothelial cells of capillaries and the basement membrane, which function to regulate the capillary vasomotor and maintain normal microcirculation of local tissues and organs and have been identified as a significant component in the tumor microenvironment (TME).
Zhongyi, Jiang, Jing, Zhou, Luohong, Li, Shan, Liao, Junyu, He, Shubo, Zhou, Yanhong, Zhou   +6 more
openaire   +2 more sources

Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

, 2021
The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in therapies targeting the tumor microenvironment.
George S. Karagiannis, John S. Condeelis, David Entenberg, Lucia Borriello, Camille L. Duran, Maja H. Oktay   +5 more
core   +1 more source

Firing up the cold tumors by targeting Vps34

OncoImmunology, 2020
Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji, Meriem Hasmim, Santiago Parpal, Guy Berchem, Muhammad Zaeem Noman   +4 more
doaj   +1 more source

Senescent Stromal Cells in the Tumor Microenvironment: Victims or Accomplices?

, 2023
Cellular senescence is a unique cellular state. Senescent cells enter a non-proliferative phase, and the cell cycle is arrested. However, senescence is essentially an active cellular phenotype, with senescent cells affecting themselves and neighboring ...
Minghan Ye, Qianju Wu, Xinyi Huang, Fei Liu   +3 more
core   +1 more source

The Tumor Microenvironment and Cancer [PDF]

BioMed Research International, 2014
Tumors are now recognized as structures of multiple cell types. It is increasingly appreciated that as the cancer progresses, the surrounding microenvironment is activated in support, coevolving through continuous paracrine communication and supporting carcinogenesis.
Zhen Chen, Zhiqiang Meng, Lijun Jia, Rutao Cui   +3 more
openaire   +2 more sources

Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses

, 2022
In contrast to surgical excision, chemotherapy or radiation therapy, immune checkpoint blockade therapies primarily influence cells in the tumor microenvironment, especially the tumor-associated lymphocytes and antigen-presenting cells.
Priscilla S. Briquez, Heidi Braumüller, Maximilian Rentschler, Thomas Wieder   +3 more
core   +1 more source

Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer

Cell Death and Disease, 2022
Aerobic glycolysis (the Warburg effect) has been demonstrated to facilitate tumor progression by producing lactate, which has important roles as a proinflammatory and immunosuppressive mediator.
Huimin Jiang, Huimin Wei, Hang Wang, Zhaoyang Wang, Jianjun Li, Yang Ou, Xuechun Xiao, Wenhao Wang, Antao Chang, Wei Sun, Li Zhao, Shuang Yang   +11 more
doaj   +1 more source

Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFβ Receptor 2

Hepatology Communications, 2020
Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen, Qing Li, Kangsheng Tu, Yuanguo Wang, Xianghu Wang, Dandan Liu, Chen Chen, Donglian Liu, Rendong Yang, Wei Qiu, Ningling Kang   +10 more
doaj   +1 more source

Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2

BMC Cancer, 2023
Objective The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, offering a new therapeutic approach ...
Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang   +10 more
doaj   +1 more source

Lipid-loaded macrophages as new therapeutic target in cancer

Journal for ImmunoTherapy of Cancer, 2022
Macrophages are main players of the innate immune system. They show great heterogeneity and play diverse functions that include support to development, sustenance of tissue homeostasis and defense against infections.
Ping-Chih Ho, Giulia Marelli, Nicolò Morina, Federica Portale, Marta Pandini, Marta Iovino, Giusy Di Conza, Diletta Di Mitri   +7 more
doaj   +1 more source