Results 21 to 30 of about 1,857,357 (268)
Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment
, 2022 SIMPLE SUMMARY: Cancers have regions of low oxygen concentration where hypoxia-related signaling pathways are activated. The hypoxic tumor microenvironment has been widely accepted as a hallmark of cancer and shown to be a critical factor in the ...
Yoo, Seongkyeong +9 more
core +1 more source
Hepatology Communications, 2020 Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen +10 more
doaj +1 more source
Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2
BMC Cancer, 2023 Objective The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, offering a new therapeutic approach ...
Ya-feng Lv +10 more
doaj +1 more source
Lipid-loaded macrophages as new therapeutic target in cancer
Journal for ImmunoTherapy of Cancer, 2022 Macrophages are main players of the innate immune system. They show great heterogeneity and play diverse functions that include support to development, sustenance of tissue homeostasis and defense against infections.
Ping-Chih Ho +7 more
doaj +1 more source
Epigenetic Modifications in Prostate Cancer Metastasis and Microenvironment
, 2023 The gradual evolution of prostate tissue from benign tumor to malignant lesion or distant metastasis is driven by intracellular epigenetic changes and the tumor microenvironment remodeling.
Yu Zeng, Shouyi Zhang, Tao Shen
core +1 more source
Role of tumor necrosis factor-alpha in zebrafish retinal neurogenesis and myelination [PDF]
International Journal of Ophthalmology, 2016 AIM: To investigate the role of tumor necrosis factor-alpha (TNF-α) in zebrafish retinal development and myelination. METHODS: Morpholino oligonucleotides (MO), which are complementary to the translation start site of the wild-type embryonic zebrafish ...
Xu-Dan Lei +5 more
doaj +1 more source
Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment
, 2021 Despite multimodal treatment, survival chances for high-risk neuroblastoma patients remain poor. Immunotherapeutic approaches focusing on the activation and/or modification of host immunity for eliminating tumor cells, such as chimeric antigen receptor ...
Leontari, Ilia +5 more
core +1 more source
Anti-S100A4 Antibody Suppresses Metastasis Formation by Blocking Stroma Cell Invasion
Neoplasia: An International Journal for Oncology Research, 2012 The small Ca-binding protein, S100A4, has a well-established metastasis-promoting activity. Moreover, its expression is tightly correlated with poor prognosis in patients with numerous types of cancer.
Jörg Klingelhöfer +6 more
doaj +1 more source
Journal of Nanobiotechnology, 2023 Macrophage polarization determines the production of cytokines that fuel the initiation and evolution of rheumatoid arthritis (RA). Thus, modulation of macrophage polarization might represent a potential therapeutic strategy for RA.
Ni Yang +12 more
doaj +1 more source
, 2022 SIMPLE SUMMARY: The tumor microenvironment (TME) plays a role in promoting tumor progression. Elucidating the relationship between the TME and tumor cells will benefit current therapies.
Chen, Ruyin +9 more
core +1 more source