Results 21 to 30 of about 652,201 (289)

Lipid-loaded macrophages as new therapeutic target in cancer

Journal for ImmunoTherapy of Cancer, 2022
Macrophages are main players of the innate immune system. They show great heterogeneity and play diverse functions that include support to development, sustenance of tissue homeostasis and defense against infections.
Ping-Chih Ho, Giulia Marelli, Nicolò Morina, Federica Portale, Marta Pandini, Marta Iovino, Giusy Di Conza, Diletta Di Mitri   +7 more
doaj   +1 more source

Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer [PDF]

, 2015
Purpose: The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment–based prognostic score, based on histopathologic ...
Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James H., Powell, Arfon G., Richards, Colin H., Roxburgh, Campbell S.D.   +6 more
core   +1 more source

Role of tumor necrosis factor-alpha in zebrafish retinal neurogenesis and myelination [PDF]

International Journal of Ophthalmology, 2016
AIM: To investigate the role of tumor necrosis factor-alpha (TNF-α) in zebrafish retinal development and myelination. METHODS: Morpholino oligonucleotides (MO), which are complementary to the translation start site of the wild-type embryonic zebrafish ...
Xu-Dan Lei, Yan Sun, Shi-Jiao Cai, Yang-Wu Fang, Jian-Lin Cui, Yu-Hao Li   +5 more
doaj   +1 more source

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Anti-S100A4 Antibody Suppresses Metastasis Formation by Blocking Stroma Cell Invasion

Neoplasia: An International Journal for Oncology Research, 2012
The small Ca-binding protein, S100A4, has a well-established metastasis-promoting activity. Moreover, its expression is tightly correlated with poor prognosis in patients with numerous types of cancer.
Jörg Klingelhöfer, Birgitte Grum-Schwensen, Mette K. Beck, Rikke Stagaard Petersen Knudsen, Mariam Grigorian, Eugene Lukanidin, Noona Ambartsumian   +6 more
doaj   +1 more source

Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis

Journal of Nanobiotechnology, 2023
Macrophage polarization determines the production of cytokines that fuel the initiation and evolution of rheumatoid arthritis (RA). Thus, modulation of macrophage polarization might represent a potential therapeutic strategy for RA.
Ni Yang, Miaomiao Li, Ling Wu, Yinhong Song, Shi Yu, Yingying Wan, Wenjing Cheng, Baoye Yang, Xiaoqin Mou, Hong Yu, Jing Zheng, Xinzhi Li, Xiang Yu   +12 more
doaj   +1 more source

Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment [PDF]

, 2019
The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with the tumor microenvironment in order to tune it for their own benefit.
Pastor Loro, Ángel Manuel, Rodríguez Matarredona, Esperanza   +1 more
core   +1 more source

The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one [PDF]

, 2018
In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice.
Botticelli, A., Marchetti, P., Nuti, M., Rughetti, A., Zizzari, I. G.   +4 more
core   +1 more source

USP51/PD‐L1/ITGB1‐deployed juxtacrine interaction plays a cell‐intrinsic role in promoting chemoresistant phenotypes in non‐small cell lung cancer

Cancer Communications, 2023
Background Programmed death ligand 1 (PD‐L1) has been demonstrated to facilitate tumor progression and therapeutic resistance in an immune‐independent manner.
Jianjun Li, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Peiqing Sun, Yi Shi, Guang Yang, Shuang Yang   +13 more
doaj   +1 more source

Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors

Journal for ImmunoTherapy of Cancer, 2023
Background Cellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells.
Benjamin Boyerinas, Greg M Delgoffe, Yupeng Wang, Alok Kumar, Ashley V Menk, Konstantinos Lontos, Yiyang Wang, Jason Lohmueller, Supriya K Joshi, Andrew T Frisch, McLane J Watson, Rachel Cumberland, Esteban Carrizosa   +12 more
doaj   +1 more source