Results 41 to 50 of about 512,927 (317)

Autophagy and ncRNAs: Dangerous Liaisons in the Crosstalk between the Tumor and Its Microenvironment [PDF]

, 2021
Autophagy is a fundamental cellular homeostasis mechanism known to play multifaceted roles in the natural history of cancers over time. It has recently been shown that autophagy also mediates the crosstalk between the tumor and its microenvironment by ...
Gracie Wee Ling Eng, Yilong Zheng, Jit Kong Cheong, Dominic Wei Ting Yap, Andrea York Tiang Teo   +4 more
core   +1 more source

Anti-S100A4 Antibody Suppresses Metastasis Formation by Blocking Stroma Cell Invasion

Neoplasia: An International Journal for Oncology Research, 2012
The small Ca-binding protein, S100A4, has a well-established metastasis-promoting activity. Moreover, its expression is tightly correlated with poor prognosis in patients with numerous types of cancer.
Jörg Klingelhöfer, Birgitte Grum-Schwensen, Mette K. Beck, Rikke Stagaard Petersen Knudsen, Mariam Grigorian, Eugene Lukanidin, Noona Ambartsumian   +6 more
doaj   +1 more source

Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis

Journal of Nanobiotechnology, 2023
Macrophage polarization determines the production of cytokines that fuel the initiation and evolution of rheumatoid arthritis (RA). Thus, modulation of macrophage polarization might represent a potential therapeutic strategy for RA.
Ni Yang, Miaomiao Li, Ling Wu, Yinhong Song, Shi Yu, Yingying Wan, Wenjing Cheng, Baoye Yang, Xiaoqin Mou, Hong Yu, Jing Zheng, Xinzhi Li, Xiang Yu   +12 more
doaj   +1 more source

Fibrocytes in the Tumor Microenvironment [PDF]

, 2020
Tumors have long been compared to chronic wounds that do not heal, since they share many of the same molecular and cellular processes. In normal wounds, healing processes lead to restoration of cellular architecture, while in malignant tumors, these healing processes become dysregulated and contribute to growth and invasion of neoplastic cells into the
David, Roife, Jason B, Fleming, Richard H, Gomer   +2 more
openaire   +2 more sources

Heterogeneity of Cancer-Associated Fibroblasts and the Tumor Immune Microenvironment in Pancreatic Cancer [PDF]

, 2022
SIMPLE SUMMARY: Stroma-targeting therapy in pancreatic ductal adenocarcinoma (PDAC) has been extensively investigated, but no candidates have shown efficacy at the clinical trial stage.
Masafumi Nakamura, Tomohiko Shinkawa, Nakamura, Masafumi, Kenoki Ohuchida, Ohuchida, Kenoki, Shinkawa, Tomohiko   +5 more
core   +1 more source

Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors

Journal for ImmunoTherapy of Cancer, 2023
Background Cellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells.
Benjamin Boyerinas, Greg M Delgoffe, Yupeng Wang, Alok Kumar, Ashley V Menk, Konstantinos Lontos, Yiyang Wang, Jason Lohmueller, Supriya K Joshi, Andrew T Frisch, McLane J Watson, Rachel Cumberland, Esteban Carrizosa   +12 more
doaj   +1 more source

Tumor microenvironment and radioresistance [PDF]

Experimental & Molecular Medicine, 2021
AbstractMetastasis is not the result of a random event, as cancer cells can sustain and proliferate actively only in a suitable tissue microenvironment and then form metastases. Since Dr. Stephen Paget in the United Kingdom proposed the seed and soil hypothesis of cancer metastasis based on the analogy that plant seeds germinate and grow only in ...
Suwa, Tatsuya, Kobayashi, Minoru, Nam, Jin-Min, Harada, Hiroshi   +3 more
openaire   +2 more sources

Tumor Microenvironment as a Therapeutic Target in Melanoma Treatment [PDF]

, 2023
The role of the tumor microenvironment in tumor growth and therapy has recently attracted more attention in research and drug development. The ability of the microenvironment to trigger tumor maintenance, progression, and resistance is the main cause for
Thomas W. Flanagan, Kharouf, Naji, Hassan, Sofie-Yasmin, Khabaz, Marla, Marla Khabaz, Sofie-Yasmin Hassan, Flanagan, Thomas W., Hassan, Sarah-Lilly, Mosaad Megahed, Megahed, Mosaad, Sarah-Lilly Hassan, Hassan, Sofie Yasmin, Hassan, Mohamed, Hosam Shalaby, Simeon Santourlidis, Mohamed Hassan, Santourlidis, Simeon, Hassan, Sarah Lilly, Shalaby, Hosam, Naji Kharouf, Youssef Haikel, Haikel, Youssef   +21 more
core   +2 more sources

USP51/PD‐L1/ITGB1‐deployed juxtacrine interaction plays a cell‐intrinsic role in promoting chemoresistant phenotypes in non‐small cell lung cancer

Cancer Communications, 2023
Background Programmed death ligand 1 (PD‐L1) has been demonstrated to facilitate tumor progression and therapeutic resistance in an immune‐independent manner.
Jianjun Li, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Peiqing Sun, Yi Shi, Guang Yang, Shuang Yang   +13 more
doaj   +1 more source

Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions [PDF]

, 2020
Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the neural crest and accounts for more than 15% of all the childhood deaths from cancer.
Shweta Joshi
core   +1 more source