Results 41 to 50 of about 1,857,357 (268)

Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, 2023
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang   +12 more
doaj   +1 more source

Bio-Mechanical Model of Osteosarcoma Tumor Microenvironment: A Porous Media Approach

, 2022
Osteosarcoma is the most common malignant bone tumor in children and adolescents with a poor prognosis. To describe the progression of osteosarcoma, we expanded a system of data-driven ODE from a previous study into a system of Reaction-Diffusion ...
Shahriyari, Leili, Mohammad Mirzaei, Navid, Yu Hu, Leili Shahriyari, Navid Mohammad Mirzaei, Hu, Yu   +5 more
core   +1 more source

Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment [PDF]

, 2021
The concept of cancer as a systemic disease, and the therapeutic implications of this, has gained special relevance. This concept encompasses the interactions between tumor and stromal cells and their microenvironment in the complex setting of primary ...
Arias Vallejo, Francisco Javier, Raquel Muñoz, Francisco Javier Arias, Girotti ., Alessandra, Hileeto, Denise, Alessandra Girotti, Denise Hileeto, Muñoz Martínez, Raquel   +7 more
core   +1 more source

Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells

Cancer Biology & Medicine
Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered ...
Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu   +10 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Role of Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity

, 2022
SIMPLE SUMMARY: Tumor associated macrophages (TAMs) support disease progression by providing tumor cells cytokines and chemokines necessary for malignant growth and nutrient support. In the tumor microenvironment (TME), TAMs often rewire their metabolism
Md Nabiul Hasan, Capuk, Okan, Shivani M. Patel, Dandan Sun, Hasan, Md Nabiul, Patel, Shivani M., Sun, Dandan, Okan Capuk   +7 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]

, 2013
Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core  

Immunosuppressive Tumor Microenvironment of Osteosarcoma. [PDF]

Background/Objectives: Osteosarcoma is the most common malignant bone tumor in children, characterized by a high degree of genomic instability, resulting in copy number alterations and genomic rearrangements without disease-defining recurrent mutations ...
Taylor, Aaron M, Aaron Michael Taylor, Flynn, William F, Silvia Regina Caminada de Toledo, Bang Hoang, Robson, Paul, Paolillo, Alini Trujillo, Paul Robson, Qian Wu, Masanori Hayashi, Bodlak, Avery, Dzis, Alissa M, Alissa M. Dzis, Fabiola Sara Balarezo, Patrick Kwok Shing Ng, Balarezo, Fabiola Sara, Luo, Diane, Kumar, Parveen, Hayashi, Masanori, Hoang, Bang, Lindsay, Adam D, Caminada de Toledo, Silvia Regina, Nathaniel L. Jillette, Petrilli, Antonio Sergio, Adam D. Lindsay, Lau, Ching C, Diane Luo, Elise T. Courtois, Goodspeed, Andrew, Michael S. Isakoff, Stephen T. C. Wong, Cao, Yuliang, Ju Young Ahn, Andrew Goodspeed, Jessica D. S. Grassmann, Wong, Stephen T C, Isakoff, Michael S, Ching C. Lau, Ahn, Ju Young, Jillette, Nathaniel L, Grassmann, Jessica D S, Harder, Jeffrey M, Jeffrey M. Harder, William F. Flynn, Jianting Sheng, Parveen Kumar, Courtois, Elise T, Wu, Qian, Yuliang Cao, Antonio Sergio Petrilli, Joshy George, Avery Bodlak, George, Joshy, Sheng, Jianting, Ng, Patrick Ks, Alini Trujillo Paolillo   +55 more
core   +1 more source

Reshaping the Pancreatic Cancer Microenvironment at Different Stages with Chemotherapy

, 2023
The dynamic tumor microenvironment, especially the immune microenvironment, during the natural progression and/or chemotherapy treatment is a critical frontier in understanding the effects of chemotherapy on pancreatic cancer.
Ying Ying, Zheng Zhang, Maozhen Peng, Wenquan Wang, Liang Liu   +4 more
core   +1 more source