Results 41 to 50 of about 1,719,424 (316)

DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment

, 2021
Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by genomic instability. MM cells present various forms of genetic instability, including chromosomal instability, microsatellite instability, and base-pair alterations, as well as
Takayuki Saitoh, Tsukasa Oda
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MRI of the tumor microenvironment [PDF]

Journal of Magnetic Resonance Imaging, 2002
AbstractThe microenvironment within tumors is significantly different from that in normal tissues. A major difference is seen in the chaotic vasculature of tumors, which results in unbalanced blood supply and significant perfusion heterogeneities. As a consequence, many regions within tumors are transiently or chronically hypoxic.
Robert J, Gillies, Natarajan, Raghunand, Gregory S, Karczmar, Zaver M, Bhujwalla   +3 more
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Glycocalyx Acts as a Central Player in the Development of Tumor Microenvironment by Extracellular Vesicles for Angiogenesis and Metastasis

, 2022
Angiogenesis in tumor growth and progression involves a series of complex changes in the tumor microenvironment. Extracellular vesicles (EVs) are important components of the tumor microenvironment, which can be classified as exosomes, apoptotic vesicles,
Zeng, Ye, Bingmei M. Fu, Qiu, Yan, Ye Zeng, Fu, Bingmei M., Jiang, Wenli, Yan Qiu, Wenli Jiang   +7 more
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Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

OncoImmunology, 2022
The modeling of chimeric antigen receptor (CAR) T cell therapies has been mostly focused on immunodeficient models. However, there are many advantages in studying CAR-T cell biology in an immunocompetent setting. We generated a fully murine CAR targeting
Konstantinos Lontos, Yiyang Wang, Mason Colbert, Alok Kumar, Supriya Joshi, Mary Philbin, Yupeng Wang, Andrew Frisch, Jason Lohmueller, Dayana B. Rivadeneira, Greg M. Delgoffe   +10 more
doaj   +1 more source

Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment

, 2021
Despite multimodal treatment, survival chances for high-risk neuroblastoma patients remain poor. Immunotherapeutic approaches focusing on the activation and/or modification of host immunity for eliminating tumor cells, such as chimeric antigen receptor ...
Leontari, Ilia, Anderson, John, Frosch, Jennifer, Jennifer Frosch, Ilia Leontari, John Anderson   +5 more
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Tumor Microenvironment and Metabolism [PDF]

International Journal of Molecular Sciences, 2017
The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...]
openaire   +3 more sources

Tumor Microenvironment in Pancreatic Intraepithelial Neoplasia

, 2021
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors with a poor prognosis. A characteristic of PDAC is the formation of an immunosuppressive tumor microenvironment (TME) that facilitates bypassing of the immune surveillance.
Friederike V. Opitz, Lena Haeberle, Irene Esposito, Alexandra Daum   +3 more
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Tumor Microenvironment as a Therapeutic Target in Melanoma Treatment [PDF]

, 2023
The role of the tumor microenvironment in tumor growth and therapy has recently attracted more attention in research and drug development. The ability of the microenvironment to trigger tumor maintenance, progression, and resistance is the main cause for
Thomas W. Flanagan, Kharouf, Naji, Hassan, Sofie-Yasmin, Khabaz, Marla, Marla Khabaz, Sofie-Yasmin Hassan, Flanagan, Thomas W., Hassan, Sarah-Lilly, Mosaad Megahed, Megahed, Mosaad, Sarah-Lilly Hassan, Hassan, Sofie Yasmin, Hassan, Mohamed, Hosam Shalaby, Simeon Santourlidis, Mohamed Hassan, Santourlidis, Simeon, Hassan, Sarah Lilly, Shalaby, Hosam, Naji Kharouf, Youssef Haikel, Haikel, Youssef   +21 more
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GM‐CSF enhances tumor invasion by elevated MMP‐2, ‐9, and ‐26 expression

Cancer Medicine, 2013
Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) promotes tumor progression in different tumor models in an autocrine and paracrine manner. However, at the same time GM‐CSF is used in cancer therapies to ameliorate neutropenia.
Claudia M. Gutschalk, Archana K. Yanamandra, Nina Linde, Alice Meides, Sofia Depner, Margareta M. Mueller   +5 more
doaj   +1 more source

Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, 2023
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang   +12 more
doaj   +1 more source