Results 51 to 60 of about 512,927 (317)

Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer [PDF]

, 2022
SIMPLE SUMMARY: The tumor suppressing effect of metformin has been reported, and tumor microenvironment including immune cells contribute to tumor progression in colorectal cancer.
Lee, Kyoung Jin, Lee, Doyeon, Kyoung Jin Lee, Tae Il Kim, Chang, Shin Young, Jae Hee Cheon, Kang, Eun Ae, Jihye Park, Kang, Joyeon, Kim, Tae Il, Park, Jae Jun, Seo, Yoojeong, Park, Soo Jung, Jaepil Eric Yoon, Doyeon Lee, Yoon, Jaepil Eric, Kwon, Ji-Hee, Janghyun Kim, Shin Young Chang, Park, Jihye, Yoojeong Seo, Cheon, Jae Hee, Joyeon Kang, Kim, Janghyun, Jae Jun Park, Ji-Hee Kwon, Soo Jung Park, Eun Ae Kang   +27 more
core   +1 more source

The Tumor Microenvironment and Cancer [PDF]

BioMed Research International, 2014
Tumors are now recognized as structures of multiple cell types. It is increasingly appreciated that as the cancer progresses, the surrounding microenvironment is activated in support, coevolving through continuous paracrine communication and supporting carcinogenesis.
Zhen Chen, Zhiqiang Meng, Lijun Jia, Rutao Cui   +3 more
openaire   +2 more sources

The Cellular Tumor Immune Microenvironment of Childhood Solid Cancers: Informing More Effective Immunotherapies [PDF]

, 2022
SIMPLE SUMMARY: Cellular immunotherapy has emerged as a novel treatment modality of cancer but is largely inefficient in solid cancers of childhood and adolescence.
Altvater, Bianca, Sareetha Kailayangiri, Kailayangiri, Sareetha, Malcolm Holterhus, Rossig, Claudia, Bianca Altvater, Holterhus, Malcolm, Claudia Rossig   +7 more
core   +1 more source

Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

Nature Communications, 2020
The transcription factor Zeb1 is known to promote tumorigenesis and stemness in breast cancer. Here the authors show that tumor endothelial Jagged1 induces activation of Notch1 signaling and increases Zeb1 expression in neighboring breast cancer stem ...
Huimin Jiang, Chen Zhou, Zhen Zhang, Qiong Wang, Huimin Wei, Wen Shi, Jianjun Li, Zhaoyang Wang, Yang Ou, Wenhao Wang, Hang Wang, Quansheng Zhang, Wei Sun, Peiqing Sun, Shuang Yang   +14 more
doaj   +1 more source

Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

OncoImmunology, 2022
The modeling of chimeric antigen receptor (CAR) T cell therapies has been mostly focused on immunodeficient models. However, there are many advantages in studying CAR-T cell biology in an immunocompetent setting. We generated a fully murine CAR targeting
Konstantinos Lontos, Yiyang Wang, Mason Colbert, Alok Kumar, Supriya Joshi, Mary Philbin, Yupeng Wang, Andrew Frisch, Jason Lohmueller, Dayana B. Rivadeneira, Greg M. Delgoffe   +10 more
doaj   +1 more source

Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas [PDF]

, 2023
Gliomas are the most common primary brain malignancy and are universally fatal. Despite significant breakthrough in understanding tumor biology, treatment breakthroughs have been limited.
Mustafa Khasraw, Kelly M. Hotchkiss, Alexander Yuile, Aditya A. Mohan, Joe Q. Wei   +4 more
core   +1 more source

Cancer-Associated Fibroblasts: Master Tumor Microenvironment Modifiers [PDF]

, 2023
Cancer cells rely on the tumor microenvironment (TME), a composite of non-malignant cells, and extracellular matrix (ECM), for survival, growth, and metastasis. The ECM contributes to the biomechanical properties of the surrounding tissue, in addition to
Andras Czirok, Kellen Wright, Thuc Ly, Sufi Mary Thomas, Matthew Kriet   +4 more
core   +1 more source

GM‐CSF enhances tumor invasion by elevated MMP‐2, ‐9, and ‐26 expression

Cancer Medicine, 2013
Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) promotes tumor progression in different tumor models in an autocrine and paracrine manner. However, at the same time GM‐CSF is used in cancer therapies to ameliorate neutropenia.
Claudia M. Gutschalk, Archana K. Yanamandra, Nina Linde, Alice Meides, Sofia Depner, Margareta M. Mueller   +5 more
doaj   +1 more source

Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, 2023
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang   +12 more
doaj   +1 more source

Imaging the Tumor Microenvironment [PDF]

The Cancer Journal, 2015
The tumor microenvironment (TME) is a complex, heterogeneous, and dominant component of solid tumors. Cancer imaging strategies of a subset of characteristics of the TME are under active development, and currently used modalities and novel approaches are summarized in this article. Understanding the dynamic and evolving functions of the TME is critical
openaire   +2 more sources