Results 51 to 60 of about 1,719,424 (316)

The Role of Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity

, 2022
SIMPLE SUMMARY: Tumor associated macrophages (TAMs) support disease progression by providing tumor cells cytokines and chemokines necessary for malignant growth and nutrient support. In the tumor microenvironment (TME), TAMs often rewire their metabolism
Md Nabiul Hasan, Capuk, Okan, Shivani M. Patel, Dandan Sun, Hasan, Md Nabiul, Patel, Shivani M., Sun, Dandan, Okan Capuk   +7 more
core   +1 more source

Tumor microenvironment revisited [PDF]

The EMBO Reports, 2014
A number of authoritative reviews devoted to the role of the tumor microenvironment have been published in recent years [1], [2]. It is evident that the tumor stroma can modulate many tumor characteristics including the response to therapy. We need to keep this in mind, especially now that there is an increasing tendency to base intervention strategies
Anton, Berns, Pier Paolo, Pandolfi
openaire   +2 more sources

Tumor Microenvironment in the Brain [PDF]

Cancers, 2012
In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression.
openaire   +2 more sources

Intratumoral Platelets: Harmful or Incidental Bystanders of the Tumor Microenvironment?

, 2022
SIMPLE SUMMARY: The tumor microenvironment (TME) is the complex and heterogenous ecosystem of solid tumors known to influence their growth and their progression.
Le Chapelain, Ophélie, Benoît Ho-Tin-Noé, Ho-Tin-Noé, Benoît, Ophélie Le Chapelain   +3 more
core   +1 more source

Targeting the tumor microenvironment [PDF]

Frontiers in Bioscience, 2007
Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma.
Kenny, P.A., Lee, G.Y., Bissell, M.J.
openaire   +3 more sources

Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells

Cancer Biology & Medicine
Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered ...
Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu   +10 more
doaj   +1 more source

Immunosuppressive Tumor Microenvironment of Osteosarcoma. [PDF]

Background/Objectives: Osteosarcoma is the most common malignant bone tumor in children, characterized by a high degree of genomic instability, resulting in copy number alterations and genomic rearrangements without disease-defining recurrent mutations ...
Taylor, Aaron M, Aaron Michael Taylor, Flynn, William F, Silvia Regina Caminada de Toledo, Bang Hoang, Robson, Paul, Paolillo, Alini Trujillo, Paul Robson, Qian Wu, Masanori Hayashi, Bodlak, Avery, Dzis, Alissa M, Alissa M. Dzis, Fabiola Sara Balarezo, Patrick Kwok Shing Ng, Balarezo, Fabiola Sara, Luo, Diane, Kumar, Parveen, Hayashi, Masanori, Hoang, Bang, Lindsay, Adam D, Caminada de Toledo, Silvia Regina, Nathaniel L. Jillette, Petrilli, Antonio Sergio, Adam D. Lindsay, Lau, Ching C, Diane Luo, Elise T. Courtois, Goodspeed, Andrew, Michael S. Isakoff, Stephen T. C. Wong, Cao, Yuliang, Ju Young Ahn, Andrew Goodspeed, Jessica D. S. Grassmann, Wong, Stephen T C, Isakoff, Michael S, Ching C. Lau, Ahn, Ju Young, Jillette, Nathaniel L, Grassmann, Jessica D S, Harder, Jeffrey M, Jeffrey M. Harder, William F. Flynn, Jianting Sheng, Parveen Kumar, Courtois, Elise T, Wu, Qian, Yuliang Cao, Antonio Sergio Petrilli, Joshy George, Avery Bodlak, George, Joshy, Sheng, Jianting, Ng, Patrick Ks, Alini Trujillo Paolillo   +55 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Melanoma and the tumor microenvironment [PDF]

Current Oncology Reports, 2008
Melanoma arises through the accrual of mutations in genes critical for proliferation and survival. Although melanoma had been traditionally conceptualized as a cell-autonomous event, increasing evidence supports the notion that these tumors are not isolated entities but rather depend, interact with, and react to the adjacent microenvironment.
Jessie, Villanueva, Meenhard, Herlyn
openaire   +2 more sources