Results 31 to 40 of about 1,857,357 (268)

USP51/PD‐L1/ITGB1‐deployed juxtacrine interaction plays a cell‐intrinsic role in promoting chemoresistant phenotypes in non‐small cell lung cancer

Cancer Communications, 2023
Background Programmed death ligand 1 (PD‐L1) has been demonstrated to facilitate tumor progression and therapeutic resistance in an immune‐independent manner.
Jianjun Li, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Peiqing Sun, Yi Shi, Guang Yang, Shuang Yang   +13 more
doaj   +1 more source

Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors

Journal for ImmunoTherapy of Cancer, 2023
Background Cellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells.
Benjamin Boyerinas, Greg M Delgoffe, Yupeng Wang, Alok Kumar, Ashley V Menk, Konstantinos Lontos, Yiyang Wang, Jason Lohmueller, Supriya K Joshi, Andrew T Frisch, McLane J Watson, Rachel Cumberland, Esteban Carrizosa   +12 more
doaj   +1 more source

Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice

, 2023
Cancer immunotherapy has brought significant clinical benefits to numerous patients with malignant disease. However, only a fraction of patients experiences complete and durable responses to currently available immunotherapies.
Dietmar Herndler-Brandstetter, Anna Chen, Ines Neuwirth   +2 more
core   +1 more source

Glycocalyx Acts as a Central Player in the Development of Tumor Microenvironment by Extracellular Vesicles for Angiogenesis and Metastasis

, 2022
Angiogenesis in tumor growth and progression involves a series of complex changes in the tumor microenvironment. Extracellular vesicles (EVs) are important components of the tumor microenvironment, which can be classified as exosomes, apoptotic vesicles,
Zeng, Ye, Bingmei M. Fu, Qiu, Yan, Ye Zeng, Fu, Bingmei M., Jiang, Wenli, Yan Qiu, Wenli Jiang   +7 more
core   +1 more source

Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

Nature Communications, 2020
The transcription factor Zeb1 is known to promote tumorigenesis and stemness in breast cancer. Here the authors show that tumor endothelial Jagged1 induces activation of Notch1 signaling and increases Zeb1 expression in neighboring breast cancer stem ...
Huimin Jiang, Chen Zhou, Zhen Zhang, Qiong Wang, Huimin Wei, Wen Shi, Jianjun Li, Zhaoyang Wang, Yang Ou, Wenhao Wang, Hang Wang, Quansheng Zhang, Wei Sun, Peiqing Sun, Shuang Yang   +14 more
doaj   +1 more source

Heterogeneity of Cancer-Associated Fibroblasts and the Tumor Immune Microenvironment in Pancreatic Cancer

, 2022
SIMPLE SUMMARY: Stroma-targeting therapy in pancreatic ductal adenocarcinoma (PDAC) has been extensively investigated, but no candidates have shown efficacy at the clinical trial stage.
Masafumi Nakamura, Tomohiko Shinkawa, Nakamura, Masafumi, Kenoki Ohuchida, Ohuchida, Kenoki, Shinkawa, Tomohiko   +5 more
core   +1 more source

Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

OncoImmunology, 2022
The modeling of chimeric antigen receptor (CAR) T cell therapies has been mostly focused on immunodeficient models. However, there are many advantages in studying CAR-T cell biology in an immunocompetent setting. We generated a fully murine CAR targeting
Konstantinos Lontos, Yiyang Wang, Mason Colbert, Alok Kumar, Supriya Joshi, Mary Philbin, Yupeng Wang, Andrew Frisch, Jason Lohmueller, Dayana B. Rivadeneira, Greg M. Delgoffe   +10 more
doaj   +1 more source

Immune Cells in the Tumor Microenvironment of Soft Tissue Sarcomas

, 2023
Soft tissue sarcomas (STSs) are a rare heterogeneous group of malignant neoplasms characterized by their aggressive course and poor response to treatment. This determines the relevance of research aimed at studying the pathogenesis of STSs. By now, it is
Timur Fatkhudinov, Enar Jumaniyazova, Anastasiya Lokhonina, Dzhuliia Dzhalilova, Anna Kosyreva   +4 more
core   +1 more source

Cancer-Associated Adipocytes and Breast Cancer: Intertwining in the Tumor Microenvironment and Challenges for Cancer Therapy

, 2023
Adipocytes are the main components in breast tissue, and cancer-associated adipocytes (CAAs) are one of the most important components in the tumor microenvironment of breast cancer (BC). Bidirectional regulation was found between CAAs and BC cells.
Xiaosong Chen, Chenghui Wu, Shuwen Dong, Renhong Huang, Wu, Chenghui, Dong, Shuwen, Huang, Renhong, Chen, Xiaosong   +7 more
core   +1 more source

GM‐CSF enhances tumor invasion by elevated MMP‐2, ‐9, and ‐26 expression

Cancer Medicine, 2013
Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) promotes tumor progression in different tumor models in an autocrine and paracrine manner. However, at the same time GM‐CSF is used in cancer therapies to ameliorate neutropenia.
Claudia M. Gutschalk, Archana K. Yanamandra, Nina Linde, Alice Meides, Sofia Depner, Margareta M. Mueller   +5 more
doaj   +1 more source