Results 11 to 20 of about 508,964 (317)
Monocytes in the Tumor Microenvironment
Annual Review of Pathology: Mechanisms of Disease, 2021 Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic and local cues during tumor development.
Stefano Ugel +2 more
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Hypoxia and the Tumor Microenvironment [PDF]
Technology in Cancer Research & Treatment, 2021 Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis.
Yue Li, Long Zhao, Xiao-Feng Li
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Indian Journal of Medical and Paediatric Oncology, 2020 A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues to support tumor growth and progression.
Azgar Abdul Rasheed +1 more
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Cell Death Discovery, 2023 Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng +8 more
doaj +1 more source
Medicina, 2019 Background and Objectives: The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer.
Arneth, Borros +1 more
openaire +5 more sources
Journal of Immunology Research, 2023 Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma +4 more
doaj +1 more source
KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis
Canadian Journal of Infectious Diseases and Medical Microbiology, 2021 Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li +4 more
doaj +1 more source
Cell Communication and Signaling, 2020 Background Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different ...
Qi Dong +14 more
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Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1
Discover Oncology, 2022 Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectiveness of treatment.
Jianjun Li +12 more
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The importance of the tumor microenvironment to understand tumor origin, evolution, and treatment response [PDF]
, 2022 During the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets.
Ignacio Ochoa Garrido +3 more
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