Results 11 to 20 of about 512,927 (317)
Hypoxia and the Tumor Microenvironment [PDF]
Technology in Cancer Research & Treatment, 2021 Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis.
Yue Li, Long Zhao, Xiao-Feng Li
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Effects of Exosomal Viral Components on the Tumor Microenvironment [PDF]
, 2022 SIMPLE SUMMARY: Oncogenic viral infection may lead to cancers, such as nasopharyngeal carcinoma, hepatocellular carcinoma, and cervical cancer. In addition to the tumor cells themselves, the tumor microenvironment also plays a decisive role in tumor ...
Jing Li +5 more
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Indian Journal of Medical and Paediatric Oncology, 2020 A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues to support tumor growth and progression.
Azgar Abdul Rasheed +1 more
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Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma [PDF]
, 2022 Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies.
Christine Alewine +7 more
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The Breast Tumor Microenvironment: A Key Player in Metastatic Spread [PDF]
, 2021 The tumor microenvironment plays a pivotal role in the tumorigenesis, progression, and metastatic spread of many cancers including breast. There is now increasing evidence to support the observations that a bidirectional interplay between breast cancer ...
Barbara E. Nickel +7 more
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Senescent Stromal Cells in the Tumor Microenvironment: Victims or Accomplices? [PDF]
, 2023 Cellular senescence is a unique cellular state. Senescent cells enter a non-proliferative phase, and the cell cycle is arrested. However, senescence is essentially an active cellular phenotype, with senescent cells affecting themselves and neighboring ...
Minghan Ye +3 more
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Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination [PDF]
, 2021 The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in therapies targeting the tumor microenvironment.
George S. Karagiannis +5 more
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Medicina, 2019 Background and Objectives: The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer.
Arneth, Borros +1 more
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Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment [PDF]
, 2022 SIMPLE SUMMARY: Cancers have regions of low oxygen concentration where hypoxia-related signaling pathways are activated. The hypoxic tumor microenvironment has been widely accepted as a hallmark of cancer and shown to be a critical factor in the ...
Yoo, Seongkyeong +9 more
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Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses [PDF]
, 2022 In contrast to surgical excision, chemotherapy or radiation therapy, immune checkpoint blockade therapies primarily influence cells in the tumor microenvironment, especially the tumor-associated lymphocytes and antigen-presenting cells.
Priscilla S. Briquez +3 more
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