Results 61 to 70 of about 512,927 (317)
Tumor microenvironment revisited [PDF]
The EMBO Reports, 2014 A number of authoritative reviews devoted to the role of the tumor microenvironment have been published in recent years [1], [2]. It is evident that the tumor stroma can modulate many tumor characteristics including the response to therapy. We need to keep this in mind, especially now that there is an increasing tendency to base intervention strategies
Anton, Berns, Pier Paolo, Pandolfi
openaire +2 more sources
The Role of Neural Signaling in the Pancreatic Cancer Microenvironment [PDF]
, 2022 Pancreatic cancer is one of the most lethal malignant diseases. Various cells in the tumor microenvironment interact with tumor cells and orchestrate to support tumor progression.
Ryota Takahashi +5 more
core +1 more source
Differential Expression of Polyamine Pathways in Human Pancreatic Tumor Progression and Effects of Polyamine Blockade on Tumor Microenvironment [PDF]
, 2021 Pancreatic cancer is the fourth leading cause of cancer death. Existing therapies only moderately improve pancreatic ductal adenocarcinoma (PDAC) patient prognosis.
Altomare, Deborah A +17 more
core +1 more source
Targeting the tumor microenvironment [PDF]
Frontiers in Bioscience, 2007 Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma.
Kenny, P.A., Lee, G.Y., Bissell, M.J.
openaire +3 more sources
Editorial for Special Issue “Brain Tumor Microenvironment” [PDF]
The tumor microenvironment (TME) is a complex interplay of cells, extracellular matrix, and signaling molecules that significantly influences tumor growth, invasion, and resistance to therapy [...
Gianluca Trevisi, Annunziato Mangiola
core +1 more source
Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment [PDF]
, 2023 To evade immune surveillance, tumors develop a hostile microenvironment that inhibits anti-tumor immunity. Recent immunotherapy breakthroughs that target the reinvigoration of tumor-infiltrating T lymphocytes (TIL) have led to unprecedented success in ...
Rong Jin +5 more
core +1 more source
Cancer Biology & MedicineObjective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered ...
Renjie Chen +10 more
doaj +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma [PDF]
, 2021 SeverFigurel cellular elements of the bone marrow (BM) microenvironment in multiple myeloma (MM) patients contribute to the immune evasion, proliferation, and drug resistance of MM cells, including myeloid-derived suppressor cells (MDSCs), tumor ...
Fatih M. Uckun
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source