Results 71 to 80 of about 1,719,424 (316)
, 2022 SIMPLE SUMMARY: Cellular immunotherapy has emerged as a novel treatment modality of cancer but is largely inefficient in solid cancers of childhood and adolescence.
Altvater, Bianca +7 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells
Journal for ImmunoTherapy of CancerBackground Oncolytic viruses (OVs) are an attractive way to increase immune infiltration into an otherwise cold tumor. While OVs are engineered to selectively infect tumor cells, there is evidence that they can infect other non-malignant cells in the ...
Greg M Delgoffe +3 more
doaj +1 more source
, 2021 Extracellular vesicles (EVs) are crucial elements that sustain the communication between tumor cells and their microenvironment, and have emerged as a widespread mechanism of tumor formation and metastasis.
Carol Encarnação +7 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The PCa Tumor Microenvironment [PDF]
Cancer Microenvironment, 2011 The tumor microenvironment (TME) is a very complex niche that consists of multiple cell types, supportive matrix and soluble factors. Cells in the TME consist of both host cells that are present at tumor site at the onset of tumor growth and cells that are recruited in either response to tumor- or host-derived factors.
Joseph L, Sottnik +3 more
openaire +2 more sources
Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells
Journal of Experimental & Clinical Cancer Research, 2019 Background In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic.
Biswajit Das, Shantibhusan Senapati
doaj +1 more source
Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]
, 2013 Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core
Immune Cells in the Tumor Microenvironment of Soft Tissue Sarcomas
, 2023 Soft tissue sarcomas (STSs) are a rare heterogeneous group of malignant neoplasms characterized by their aggressive course and poor response to treatment. This determines the relevance of research aimed at studying the pathogenesis of STSs. By now, it is
Timur Fatkhudinov +4 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source