Results 81 to 90 of about 512,927 (317)

Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies

Frontiers in Pharmacology, 2021
The Syrian golden hamster (Mesocricetus auratus) has recently been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins in these animals ...
Voddu Suresh, Voddu Suresh, Deepti Parida, Deepti Parida, Aliva P. Minz, Aliva P. Minz, Manisha Sethi, Manisha Sethi, Bhabani S. Sahoo, Shantibhusan Senapati   +9 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Tumor Microenvironment and Metabolism [PDF]

International Journal of Molecular Sciences, 2017
The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...]
openaire   +3 more sources

Crosstalk between Thyroid Carcinoma and Tumor-Correlated Immune Cells in the Tumor Microenvironment [PDF]

, 2023
Thyroid cancer (TC) is the most common malignancy in the endocrine system. Although most TC can achieve a desirable prognosis, some refractory thyroid carcinomas, including radioiodine-refractory differentiated thyroid cancer, as well as anaplastic ...
Mingyuan Song, Hao Zhang, Wei Sun, Qi Liu   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Immunosuppressive Tumor Microenvironment of Osteosarcoma. [PDF]

Background/Objectives: Osteosarcoma is the most common malignant bone tumor in children, characterized by a high degree of genomic instability, resulting in copy number alterations and genomic rearrangements without disease-defining recurrent mutations ...
Taylor, Aaron M, Aaron Michael Taylor, Flynn, William F, Silvia Regina Caminada de Toledo, Bang Hoang, Robson, Paul, Paolillo, Alini Trujillo, Paul Robson, Qian Wu, Masanori Hayashi, Bodlak, Avery, Dzis, Alissa M, Alissa M. Dzis, Fabiola Sara Balarezo, Patrick Kwok Shing Ng, Balarezo, Fabiola Sara, Luo, Diane, Kumar, Parveen, Hayashi, Masanori, Hoang, Bang, Lindsay, Adam D, Caminada de Toledo, Silvia Regina, Nathaniel L. Jillette, Petrilli, Antonio Sergio, Adam D. Lindsay, Lau, Ching C, Diane Luo, Elise T. Courtois, Goodspeed, Andrew, Michael S. Isakoff, Stephen T. C. Wong, Cao, Yuliang, Ju Young Ahn, Andrew Goodspeed, Jessica D. S. Grassmann, Wong, Stephen T C, Isakoff, Michael S, Ching C. Lau, Ahn, Ju Young, Jillette, Nathaniel L, Grassmann, Jessica D S, Harder, Jeffrey M, Jeffrey M. Harder, William F. Flynn, Jianting Sheng, Parveen Kumar, Courtois, Elise T, Wu, Qian, Yuliang Cao, Antonio Sergio Petrilli, Joshy George, Avery Bodlak, George, Joshy, Sheng, Jianting, Ng, Patrick Ks, Alini Trujillo Paolillo   +55 more
core   +2 more sources

Epigenetic Modifications in Prostate Cancer Metastasis and Microenvironment [PDF]

, 2023
The gradual evolution of prostate tissue from benign tumor to malignant lesion or distant metastasis is driven by intracellular epigenetic changes and the tumor microenvironment remodeling.
Yu Zeng, Shouyi Zhang, Tao Shen
core   +1 more source

Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells

Journal for ImmunoTherapy of Cancer
Background Oncolytic viruses (OVs) are an attractive way to increase immune infiltration into an otherwise cold tumor. While OVs are engineered to selectively infect tumor cells, there is evidence that they can infect other non-malignant cells in the ...
Greg M Delgoffe, Kristin DePeaux, William G Gunn, Dayana B Rivadeneira   +3 more
doaj   +1 more source

Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells

Journal of Experimental & Clinical Cancer Research, 2019
Background In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic.
Biswajit Das, Shantibhusan Senapati
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source