Results 101 to 110 of about 1,719,424 (316)

Targeting Cellular Components of the Tumor Microenvironment in Solid Malignancies

, 2022
Cancers are composed of transformed cells, characterized by aberrant growth and invasiveness, in close relationship with non-transformed healthy cells and stromal tissue.
Gabriele Antonarelli, Boscolo Bielo, Luca, Giuseppe Curigliano, Carmen Belli, Luca Boscolo Bielo, Curigliano, Giuseppe, Edoardo Crimini, Repetto, Matteo, Matteo Repetto, Antonarelli, Gabriele, Crimini, Edoardo, Belli, Carmen   +11 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Crosstalk between Thyroid Carcinoma and Tumor-Correlated Immune Cells in the Tumor Microenvironment

, 2023
Thyroid cancer (TC) is the most common malignancy in the endocrine system. Although most TC can achieve a desirable prognosis, some refractory thyroid carcinomas, including radioiodine-refractory differentiated thyroid cancer, as well as anaplastic ...
Mingyuan Song, Hao Zhang, Wei Sun, Qi Liu   +3 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes

, 2023
Platelets, the primary operatives of hemostasis that contribute to blood coagulation and wound healing after blood vessel injury, are also involved in pathological conditions, including cancer. Malignancy-associated thrombosis is common in ovarian cancer
Selin Oncul, Min Soon Cho
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Regulation of Macrophage Polarization Mediated by Extracellular Vesicle During Bacterial Infection

Cellular Microbiology
Extracellular vesicles (EVs) are nanovesicles secreted by cells with lipid bilayer structure, which play a key role in the communication between bacteria and host cells.
Xiaoqin Mou, Li Wang, Jun Wang, Chuang Cheng, Xi Zheng, Jing He, Yueqing Wang, Qingyong Zhang, Lili Zou, Xiaowen Liu   +9 more
doaj   +1 more source

Enhanced Thermogenesis in Triple-Negative Breast Cancer Is Associated with Pro-Tumor Immune Microenvironment

, 2021
Mild cold stress induced by housing mice with a 4T1 triple-negative breast cancer (TNBC) cell implantation model at 22 °C increases tumor growth rate with a pro-tumorigenic immune microenvironment (lower CD8 +T cells, higher myeloid-derived suppressor ...
Vijayashree Murthy, Masanori Oshi, Kazuaki Takabe, Shipra Gandhi, Elizabeth A. Repasky   +4 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Comprehensive Review of Hedyotis Diffusa Willd–Scutellaria Barbata D. Don Herb Pair in Anti- Hepatocellular Carcinoma Effects and Their Combinatorial Effects and Mechanisms

Drug Design, Development and Therapy
Ya Xu,1– 3 Weijia Xiang,1– 3 Wanyi Zhu,1– 3 Lanqi Shang,1– 3 Mengting Lun,1– 3 Songyan Qu,1– 3 Yizhen Yin,1– 3 Changrong Chen,4 Honggang Yuan,5 Yinhong Song1– 3 1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges ...
Xu Y, Xiang W, Zhu W, Shang L, Lun M, Qu S, Yin Y, Chen C, Yuan H, Song Y   +9 more
doaj