Results 21 to 30 of about 226,828 (255)
The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer
Frontiers in Oncology, 2021 Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
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Targeting glycolysis in non-small cell lung cancer: Promises and challenges
Frontiers in Pharmacology, 2022 Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as non-small cell lung cancer (NSCLC). Cancer cells tend to reprogram a majority of glucose metabolism reactions into glycolysis, even in oxygen-rich environments ...
Jia-Qi Xu +8 more
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Diabetologia, 1993 Glycolysis is usually considered as a paradigm metabolic pathway, due to the fact that it is present in most organisms, and also because it is the pathway by which an important nutrient, glucose, is consumed. Far from being completely understood, the regulation of this pathway witnessed several important progresses during the last few years.
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mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
Cell Reports, 2015 The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune cells and cellular energy metabolism. Although glycolysis has been linked to immune functions, the mechanisms by which glycolysis regulates NLRP3 inflammasome activation ...
Jong-Seok Moon +6 more
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The roles of glycolysis in osteosarcoma
Frontiers in Pharmacology, 2022 Metabolic reprogramming is of great significance in the progression of various cancers and is critical for cancer progression, diagnosis, and treatment.
Zuxi Feng, Yanghuan Ou, Liang Hao
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eLife, 2014 Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype.
Alexander A Shestov +10 more
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Immunity, Inflammation and Disease, 2022 NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been tied with metabolic reprogramming characterized by high glycolysis and low oxidative phosphorylation.
Qun Yu +8 more
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Frontiers in Oncology, 2022 BackgroundThe dysregulated expression of aerobic glycolysis-related genes is closely related to prostate cancer progression and metastasis. However, reliable prognostic signatures based on aerobic glycolysis have not been well established.MethodsWe ...
Wei He, Xiang He, Enhui Li
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PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
Protein & Cell, 2019 A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are
Tong Li +5 more
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Molecular Metabolism, 2023 Objective: Cancer cells use glycolysis for generation of metabolic intermediates and ATP needed for cell growth and proliferation. The transcription factor C/EBPβ-LIP stimulates glycolysis and mitochondrial respiration in cancer cells.
Tobias Ackermann +8 more
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