Results 11 to 20 of about 291,093 (299)

Natural products target glycolysis in liver disease [PDF]

Frontiers in Pharmacology, 2023
Mitochondrial dysfunction plays an important role in the occurrence and development of different liver diseases. Oxidative phosphorylation (OXPHOS) dysfunction and production of reactive oxygen species are closely related to mitochondrial dysfunction ...
Shenghao Li, Shenghao Li, Liyuan Hao, Liyuan Hao, Xiaoyu Hu   +4 more
doaj   +2 more sources

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Zoltan Oltvai, Zoltan N. Oltvai   +2 more
core   +3 more sources

Hexokinases II‐mediated glycolysis governs susceptibility to crizotinib in ALK‐positive non‐small cell lung cancer

Thoracic Cancer, 2021
Background Activation of ALK leads to a high level of aerobic glycolysis related to crizotinib insensitivity in anaplastic lymphoma kinase‐positive non‐small cell lung cancer (ALK+ NSCLC).
Caiyu Lin, Hengyi Chen, Rui Han, Li Li, Conghua Lu, Shuai Hao, Yubo Wang, Yong He   +7 more
doaj   +1 more source

The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment

Frontiers in Pharmacology, 2022
It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Daoying Zhou, Daoying Zhou, Zhen Duan, Zhenyu Li, Zhenyu Li, Fangfang Ge, Fangfang Ge, Ran Wei, Lingsuo Kong   +8 more
doaj   +1 more source

Neurons require glucose uptake and glycolysis in vivo

Cell Reports, 2023
Summary: Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we show that human neurons do metabolize glucose through glycolysis and can rely on ...
Huihui Li, Caroline Guglielmetti, Yoshitaka J. Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields, Joyce Yang, Kevin Nguyen, Brice Tiret, Xiao Gao, Neal Bennett, Iris Lo, Talya L. Dayton, Martin Kampmann, Yadong Huang, Jeffrey C. Rathmell, Matthew Vander Heiden, Myriam M. Chaumeil, Ken Nakamura   +18 more
doaj   +1 more source

Data_Sheet_5_Identification of a Three-Glycolysis-Related lncRNA Signature Correlated With Prognosis and Metastasis in Clear Cell Renal Cell Carcinoma.xlsx

, 2022
The clear cell renal cell carcinoma (ccRCC) is not only a malignant disease but also an energy metabolic disease, we aimed to identify a novel prognostic model based on glycolysis-related long non-coding RNA (lncRNAs) and explore its mechanisms. With the
Tinghao Li (10507577), Junlong Zhu (10507568), Weiyang He (8079503), Hang Tong (10507565), Zijia Qin (10507574), Xudong Liu (6899), Siwen Yin (11659675), Yan Sun (22436)   +7 more
core   +1 more source

Image_1_Identification of a Three-Glycolysis-Related lncRNA Signature Correlated With Prognosis and Metastasis in Clear Cell Renal Cell Carcinoma.JPEG

, 2022
The clear cell renal cell carcinoma (ccRCC) is not only a malignant disease but also an energy metabolic disease, we aimed to identify a novel prognostic model based on glycolysis-related long non-coding RNA (lncRNAs) and explore its mechanisms. With the
Tinghao Li (10507577), Junlong Zhu (10507568), Weiyang He (8079503), Hang Tong (10507565), Zijia Qin (10507574), Xudong Liu (6899), Siwen Yin (11659675), Yan Sun (22436)   +7 more
core   +1 more source

SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis

Frontiers in Cell and Developmental Biology, 2022
Increased dependence on aerobic glycolysis is characteristic of most cancer cells, whereas the mechanism underlying the promotion of aerobic glycolysis in metastatic breast cancer cells under ambient oxygen has not been well understood.
Chenguang Yao, Jun Weng, Lingyun Feng, Wanjun Zhang, Yan Xu, Peijing Zhang, Yoshimasa Tanaka, Li Su   +7 more
doaj   +1 more source

Data_Sheet_3_Identification of a Three-Glycolysis-Related lncRNA Signature Correlated With Prognosis and Metastasis in Clear Cell Renal Cell Carcinoma.xlsx

, 2022
The clear cell renal cell carcinoma (ccRCC) is not only a malignant disease but also an energy metabolic disease, we aimed to identify a novel prognostic model based on glycolysis-related long non-coding RNA (lncRNAs) and explore its mechanisms. With the
Tinghao Li (10507577), Junlong Zhu (10507568), Weiyang He (8079503), Hang Tong (10507565), Zijia Qin (10507574), Xudong Liu (6899), Siwen Yin (11659675), Yan Sun (22436)   +7 more
core   +1 more source

Intratumor microbiome derived glycolysis-lactate signatures depicts immune heterogeneity in lung adenocarcinoma by integration of microbiomic, transcriptomic, proteomic and single-cell data

Frontiers in Microbiology, 2023
IntroductionMicrobiome plays roles in lung adenocarcinoma (LUAD) development and anti-tumor treatment efficacy. Aberrant glycolysis in tumor might promote lactate production that alter tumor microenvironment, affecting microbiome, cancer cells and immune
Xiaheng Deng, Xiru Chen, Yu Luo, Jun Que, Liang Chen   +4 more
doaj   +1 more source