Results 11 to 20 of about 339,187 (240)
Neurons require glucose uptake and glycolysis in vivo
Cell Reports, 2023 In brief Whether neurons can and must take up glucose and metabolize it by glycolysis was unclear, especially in vivo. Li et al. combine metabolomics and live imaging of human neurons with mouse models disrupting key steps in glucose metabolism to ...
Huihui Li +18 more
semanticscholar +3 more sources
Natural products target glycolysis in liver disease [PDF]
Frontiers in Pharmacology, 2023 Mitochondrial dysfunction plays an important role in the occurrence and development of different liver diseases. Oxidative phosphorylation (OXPHOS) dysfunction and production of reactive oxygen species are closely related to mitochondrial dysfunction ...
Shenghao Li, Xiaoyu Hu, Liyuan Hao
core +3 more sources
Glycolysis drives STING signaling to facilitate dendritic cell antitumor function
The Journal of Clinical Investigation, 2023 Activation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive.
Zhilin Hu +11 more
semanticscholar +2 more sources
Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases [PDF]
International Journal of Ophthalmology, 2021 Glycolysis produces large amounts of adenosine triphosphate (ATP) in a short time. The retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less ATP.
Ting-Ting Yang, Hui Li, Li-Jie Dong
doaj +1 more source
A prediction model identifying glycolysis signature as therapeutic target for psoriasis
Frontiers in Immunology, 2023 BackgroundThe hyperproliferation featured with upregulated glycolysis is a hallmark of psoriasis. However, molecular difference of keratinocyte glycolysis amongst varied pathologic states in psoriasis remain elusive.ObjectivesTo characterize glycolysis ...
Yanhong Shou +3 more
doaj +1 more source
The activation of the metabolic oxaloacetate-pyruvate axis restores influenza A virus replication during impaired glycolysis. [PDF]
Virol JViruses strongly depend on the host cell for efficient replication and influenza A virus (IAV) amongst others also lead to remarkable changes of the host cell metabolism.
Bojarzyn CR +5 more
europepmc +2 more sources
Frontiers in Immunology, 2022 Alzheimer’s disease (AD) is a common neurodegenerative disorder without an effective treatment, and results in an increasingly serious health problem. However, its pathogenesis is complex and poorly understood.
Zhiqiang Qiu +8 more
doaj +1 more source
Natural products targeting glycolysis in cancer
Frontiers in Pharmacology, 2022 Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cells ...
Yuanyuan Zhao +5 more
doaj +1 more source
On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects
Cells, 2023 Reprogramming energy production from mitochondrial respiration to glycolysis is now considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to changes in their microenvironment (e.g., hypoxia, mechanical stress) that are ...
Fabrizio Marcucci, Cristiano Rumio
doaj +1 more source
BMC Medicine, 2021 Background Long noncoding (lnc)RNAs and glycolysis are both recognized as key regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis metabolism.
Kuo-Hao Ho +6 more
doaj +1 more source