Results 11 to 20 of about 360,735 (338)
Effects of altered glycolysis levels on CD8+ T cell activation and function
Cell Death and Disease, 2023 CD8+ T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated to exert their immune function by producing cytokines.
Jiaying Cao +5 more
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Modulating Glycolysis to Improve Cancer Therapy
International Journal of Molecular Sciences, 2023 Cancer cells undergo metabolic reprogramming and switch to a ‘glycolysis-dominant’ metabolic profile to promote their survival and meet their requirements for energy and macromolecules.
Vipin Shankar Chelakkot +2 more
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Neurons require glucose uptake and glycolysis in vivo
Cell Reports, 2023 Summary: Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we show that human neurons do metabolize glucose through glycolysis and can rely on ...
Huihui Li +18 more
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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
Cell Metabolism, 2022 High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However, whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is unknown.
Xuxiao He
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Frontiers in Pharmacology, 2022 It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Daoying Zhou +8 more
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Glycolysis drives STING signaling to facilitate dendritic cell antitumor function
The Journal of Clinical Investigation, 2023 Activation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive.
Zhilin Hu +11 more
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A bioenergetic understanding of “aerobic glycolysis” [PDF]
Communications Biology“Aerobic glycolysis” is a widely used term whose current meaning has drifted from its original usage in a way that has created confusion and inaccuracy. This drift has weakened “aerobic glycolysis” as a hypothesis-testing framework, despite the critical ...
Valerie L. Wasem, Shona A. Mookerjee
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Glycolysis in the control of blood glucose homeostasis
Acta Pharmaceutica Sinica B, 2012 Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion and metabolic functions of various cells. Depending on cell types, rates of glycolysis are determined at various steps of glycolysis that are subjected to the ...
Chaodong Wu, Hang Xu, Alex J Lange
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PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
Protein and Cell, 2019 A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are
Tong Li, Yiguo Wang, Liangjie Jia
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