Results 31 to 40 of about 339,187 (240)
, 2022 The clear cell renal cell carcinoma (ccRCC) is not only a malignant disease but also an energy metabolic disease, we aimed to identify a novel prognostic model based on glycolysis-related long non-coding RNA (lncRNAs) and explore its mechanisms. With the
Tinghao Li (10507577) +7 more
core +1 more source
, 2011 Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez +2 more
core +3 more sources
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. [PDF]
PLoS ONE, 2011 Previous experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP. Here we use a genome-
Alexei Vazquez +2 more
doaj +1 more source
Diabetologia, 1993 Glycolysis is usually considered as a paradigm metabolic pathway, due to the fact that it is present in most organisms, and also because it is the pathway by which an important nutrient, glucose, is consumed. Far from being completely understood, the regulation of this pathway witnessed several important progresses during the last few years.
openaire +2 more sources
Human Genomics, 2022 Background Aerobic glycolysis is an emerging hallmark of cancer. Although some studies have constructed glycolysis-related prognostic models of colon adenocarcinoma (COAD) based on The Cancer Genome Atlas (TCGA) database, whether the COAD glycolysis ...
Zhenzhen Liu +9 more
doaj +1 more source
The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer
Frontiers in Oncology, 2021 Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
doaj +1 more source
Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
Journal of Physiology, 2020 Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP levels.
S. Kierans, C. Taylor
semanticscholar +1 more source
m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
Molecular Cancer, 2023 Glycolytic reprogramming is one of the most important features of cancer and plays an integral role in the progression of cancer. In cancer cells, changes in glucose metabolism meet the needs of self-proliferation, angiogenesis and lymphangiogenesis ...
Shiwei Yue +6 more
semanticscholar +1 more source
Targeting glycolysis in non-small cell lung cancer: Promises and challenges
Frontiers in Pharmacology, 2022 Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as non-small cell lung cancer (NSCLC). Cancer cells tend to reprogram a majority of glucose metabolism reactions into glycolysis, even in oxygen-rich environments ...
Jia-Qi Xu +8 more
doaj +1 more source
Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma
Journal of experimental & clinical cancer research : CR, 2020 Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sorafenib is the first targeted drug for advanced
Jiao Feng +7 more
semanticscholar +1 more source