Results 51 to 60 of about 339,187 (240)

Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis

Critical Care, 2022
Background Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate cellular immunity and play vital roles in clearing pathogenic bacteria ...
T. Pan, Shaoqiong Sun, Yang Chen, Rui Tian, E. Chen, R. Tan, Xiaoli Wang, Zhaojun Liu, Jialin Liu, H. Qu   +9 more
semanticscholar   +1 more source

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

eLife, 2014
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype.
Alexander A Shestov, Xiaojing Liu, Zheng Ser, Ahmad A Cluntun, Yin P Hung, Lei Huang, Dongsung Kim, Anne Le, Gary Yellen, John G Albeck, Jason W Locasale   +10 more
doaj   +1 more source

Interaction networks of macrophage glycolysis and inflammation in sepsis: mechanisms and therapeutic potential. [PDF]

Front Immunol
Sepsis is a severe threat to human health with high mortality rates, but so far its pathogenesis is unclear and lacks effective therapeutic drugs. Macrophages function as one of the most important innate immune cells and play an integral role in the ...
Luo P, Liu H, Zhang T, He W.
europepmc   +2 more sources

Glycolysis – a key player in the inflammatory response

The FEBS Journal, 2020
The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis.
G. Soto-Heredero, M. M. Gómez de las Heras, E. Gabandé-Rodríguez, J. Oller, M. Mittelbrunn   +4 more
semanticscholar   +1 more source

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

Journal of experimental & clinical cancer research : CR, 2022
Background N6-methyladenosine (m 6 A) modification is the most common chemical modification in mammalian mRNAs, and it plays important roles by regulating several cellular processes.
Jiapeng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang, Dalin Zhang, W. Dong, Liang Shao, Liang He, Xiaoyue Ji, Ping Zhang, Hao Zhang   +11 more
semanticscholar   +1 more source

Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis

Nature Chemical Biology
Lysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the ...
Di Zhang, Jinjun Gao, Zhijun Zhu, Qianying Mao, Zhiqiang Xu, Pankaj K. Singh, Cornelius C. Rimayi, C. Moreno-Yruela, Shuling Xu, Gongyu Li, Yi-Cheng Sin, Yue Chen, C. Olsen, Nathaniel W. Snyder, Lunzhi Dai, Lingjun Li, Yingming Zhao   +16 more
semanticscholar   +1 more source

Comprehensive analysis of aerobic glycolysis-related genes for prognosis, immune features and drug treatment strategy in prostate cancer

Frontiers in Oncology, 2022
BackgroundThe dysregulated expression of aerobic glycolysis-related genes is closely related to prostate cancer progression and metastasis. However, reliable prognostic signatures based on aerobic glycolysis have not been well established.MethodsWe ...
Wei He, Xiang He, Enhui Li
doaj   +1 more source

Glycolysis: A multifaceted metabolic pathway and signaling hub

Journal of Biological Chemistry
Glycolysis is a highly conserved metabolic pathway responsible for the anaerobic production of adenosine triphosphate (ATP) from the breakdown of glucose molecules.
S. Kierans, Cormac T. Taylor
semanticscholar   +1 more source

Mechanical regulation of glycolysis via cytoskeleton architecture

Nature, 2020
The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility1–3.
Jin Suk Park, C. Burckhardt, R. Lazcano, L. Solis, T. Isogai, Linqing Li, Christopher S. Chen, B. Gao, J. Minna, R. Bachoo, R. Deberardinis, G. Danuser   +11 more
semanticscholar   +1 more source

Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism [PDF]

, 2012
Kinetic models of metabolism require detailed knowledge of kinetic parameters. However, due to measurement errors or lack of data this knowledge is often uncertain.
Achcar, Fiona,, Kerkhoven Eduard J., Barrett, M.P., Breitling, Rainer, Breitling, R., Fiona Achcar, Breitling, Rainer,, Bakker, Barbara M.; id_orcid, Achcar, Fiona, Achcar, F., Eduard J. Kerkhoven (187101), Fiona Achcar (187100), Breitling Rainer, Bakker Barbara M., SilicoTryp Consortium, Barrett, Michael P., Rainer Breitling (4371), Michael P Barrett, Bakker, B.M., Barbara M. Bakker (102159), Barrett, Michael P.,, Bakker, Barbara M., Barbara M Bakker, Kerkhoven, Eduard J, Matthews, Keith; id_orcid, Kerkhoven, Eduard J.,, Bakker, Barbara M, Rainer Breitling, Barrett, Michael P, Kerkhoven, E.J., ?, ?, Eduard J Kerkhoven, Achcar Fiona, Barrett Michael P., Bakker, Barbara M.,, Kerkhoven, Eduard J., Michael P. Barrett (167748)   +36 more
core   +1 more source