Results 51 to 60 of about 360,735 (338)

Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex

Hepatology, 2023
Background and Aims: Aerobic glycolysis reprogramming occurs during HSC activation, but how it is initiated and sustained remains unknown. We investigated the mechanisms by which canonical Wnt signaling regulated HSC glycolysis and the therapeutic ...
Feixia Wang, Li Chen, Desong Kong, Xiaojing Zhang, Si-wei Xia, Baoyu Liang, Yang Li, Ya Zhou, Zi-Li Zhang, Jiang-Juan Shao, Shizhong Zheng, Feng Zhang   +11 more
semanticscholar   +1 more source

Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis

Nature Chemical Biology
Lysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the ...
Di Zhang, Jinjun Gao, Zhijun Zhu, Qianying Mao, Zhiqiang Xu, Pankaj K. Singh, Cornelius C. Rimayi, C. Moreno-Yruela, Shuling Xu, Gongyu Li, Yi-Cheng Sin, Yue Chen, C. A. Olsen, Nathaniel W. Snyder, Lunzhi Dai, Lingjun Li, Yingming Zhao   +16 more
semanticscholar   +1 more source

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.

Annual Review of Cell and Developmental Biology, 2011
Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells.
Sophia Y. Lunt, M. V. Vander Heiden
semanticscholar   +1 more source

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes [PDF]

, 2013
peer reviewedWe present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a
Carroll, Kathleen M, Paton, Norman W, Mendes, Pedro, McCarthy, John E G, Carroll, K.M., Weichart, D., Broomhead, David S., Murabito, Ettore, Khan, Farid, Messiha, Hanan L.,, Dunn, Warwick B., Oliver, Stephen G,, Swainston, N., Broomhead, D. S., Dada, Joseph O., Oliver, Stephen G., Westerhoff, H.V.; id_orcid, Kell, Douglas B.,, Kell, D.B., Gaskell, Simon J, Winder, Catherine L., Malys, Naglis, Dada, J.O., Westerhoff, Hans V.,, Pir, P., Paton, N.W., Pendes, Pedro, Pir, Pınar,, Murabito, Ettore,, Messiha, H.L., Paton, Norman W., Westerhoff, Hans V., Gaskell, Simon J., Dunn, Warwick B.,, Simeonidis, E., Kell, Douglas B., Simeonidis, Evangelos,, Khan, Farid,, Jameson, Daniel; id_orcid, Gaskell, S.J., Jameson, Daniel, Dada, Joseph O, Carroll, Kathleen M.,, Spasić, I., Kell, Douglas B, Smallbone, K., Winder, Catherine L, Mendes, P., McCarthy, John E. G., Hayes, Neil W., Paton, Norman; id_orcid, Spasic, Irena, Weichart, Dieter, Pir, Pınar, Gaskell, S. J., Carroll, Kathleen M., Dunn, W.B., Jameson, Daniel,, Jameson, D., Gaskell, Simon J.,, Malys, N., Paton, Norman W.,, Malys, Naglis,, SIMEONIDIS, Vangelis, Smallbone, Kieran,, Simeonidis, Evangelos, Wishart, J., Messiha, Hanan L, Wishart, Jill,, Westerhoff, Hans V, McCarthy, John E G,, Murabito, E., Khan, F., Oliver, Stephen G, Wishart, Jill, Broomhead, David S, Messiha, Hanan L., Dunn, Warwick B, Winder, C.L., Jameson, D,, Dada, Joseph O.,, Swainston, Neil,, Weichart, Dieter,, Oliver, S. G., Hayes, N.W., Pir, Pinar, Spasić, Irena,, Broomhead, D.S., Mendes, Pedro,, Broomhead, David S.,, McCarthy, John E.G., Hayes, Neil W, Hayes, Neil W.,, Oliver, S.G., Swainston, Neil, Smallbone, Kieran, McCarthy, J.E.G., Winder, Catherine L.,, Westerhoff, H.V., Carroll, Kathleen M; id_orcid   +99 more
core   +2 more sources

Glycolysis: A multifaceted metabolic pathway and signaling hub

Journal of Biological Chemistry
Glycolysis is a highly conserved metabolic pathway responsible for the anaerobic production of adenosine triphosphate (ATP) from the breakdown of glucose molecules.
S. Kierans, Cormac T. Taylor
semanticscholar   +1 more source

Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

Journal of experimental & clinical cancer research : CR, 2020
Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sorafenib is the first targeted drug for advanced
Jiao Feng, Jing-Jing Li, Liwei Wu, Qiang Yu, J. Ji, Jianye Wu, Wei-qi Dai, Chuanyong Guo   +7 more
semanticscholar   +1 more source

M2 Tumor‐Associated Macrophages‐Derived Exosomal MALAT1 Promotes Glycolysis and Gastric Cancer Progression

Advancement of science
M2‐polarized tumor‐associated macrophages (M2 TAMs) promote cancer progression. Exosomes mediate cellular communication in the tumor microenvironment (TME). However, the roles of exosomes from M2 TAMs in gastric cancer progression are unclear. Herein, it
Yanzheng Wang, Jiahui Zhang, Hui Shi, Maoye Wang, Dan Yu, Min Fu, Yu Qian, Xiao-Xin Zhang, Runbi Ji, Shouyu Wang, Jianmei Gu, Xu Zhang   +11 more
semanticscholar   +1 more source

Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect [PDF]

, 2011
The Warburg effect - a classical hallmark of cancer metabolism - is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily ...
Tomer Shlomi, Eyal Gottlieb, Gottlieb, E., Shlomi, T., Gottlieb Eyal, Roded Sharan, Eytan Ruppin, Ruppin Eytan, Tomer Benyamini, Shlomi Tomer, Sharan Roded, Benyamini Tomer, Ruppin, E., Benyamini, T., Sharan, R.   +14 more
core   +1 more source

Mitochondrial ATP generation is more proteome efficient than glycolysis

Nature Chemical Biology
Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily through glycolysis and respiration.
Yihui Shen, Hoang V. Dinh, Edward Cruz, Zi-Hong Chen, Caroline R. Bartman, Tianxia Xiao, Catherine M. Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel R. Weilandt, Heide Baron, Arjuna M. Subramanian, Z. Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I Hendry, V. Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, C. Maranas, Martin Wühr, Joshua D. Rabinowitz   +22 more
semanticscholar   +1 more source

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

Journal of experimental & clinical cancer research : CR, 2022
Background N6-methyladenosine (m 6 A) modification is the most common chemical modification in mammalian mRNAs, and it plays important roles by regulating several cellular processes.
Jia-Peng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang, Dalin Zhang, W. Dong, Liang Shao, Liang He, Xiaoyue Ji, Ping Zhang, Hao Zhang   +11 more
semanticscholar   +1 more source