Results 71 to 80 of about 360,735 (338)

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

bioRxiv, 2020
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo, Zhao-Qi Li, Dan Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do, R. Ferreira, Adi Naamati, Ahmed Y. Ali, Caroline A. Lewis, Craig J. Thomas, S. Spranger, N. Matheson, M. V. Vander Heiden   +13 more
semanticscholar   +1 more source

Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis

Critical Care, 2022
Background Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate cellular immunity and play vital roles in clearing pathogenic bacteria ...
T. Pan, Shaoqiong Sun, Yang Chen, R. Tian, E. Chen, R. Tan, Xiaoli Wang, Zhaojun Liu, Jialin Liu, H. Qu   +9 more
semanticscholar   +1 more source

Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas [PDF]

, 2011
Background HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model.
Golinska Monika, Chung Yuen-Li, Stubbs Marion, Airley Rachel E, Troy Helen, Williams, Kaye J., Williams, KJ, Mayr, Manuel, McSheehy, PM, Monika Golinska, Rachel E Airley, Yin, Xiaoke; id_orcid, Stubbs, M, Xiaoke Yin, Airley, Rachel E., Lucy Ly, Troy, H, Perumal Meg, Adrian L Harris, Eric O Aboagye, Mayr, Manuel; id_orcid, Golinska, Monika, Aboagye, Eric O., Kaye J Williams, Yuen-Li Chung, Manuel Mayr, Yin, X, Chung, Yuen Li, John Latigo, McSheehy, Paul M., Chung, YL, Golinska, M, Griffiths John R, Ly Lucy, Helen Troy, Chung, Yuen-Li, Mayr, M, Stubbs, Marion, Latigo John, Perrett, D, Perrett David, John R Griffiths, Aboagye Eric O, Harris, AL, Perrett, David, Griffiths, John R., Perumal, M, Williams Kaye J, Latigo, J, Perumal, Meg, Mayr Manuel, Griffiths, JR, Ly, Lucy, Airley, RE, Marion Stubbs, McSheehy Paul M, David Perrett, Ly, L, Yin, Xiaoke, Troy, Helen, Aboagye, EO, Latigo, John, Meg Perumal, Harris Adrian L, Yin Xiaoke, Harris, Adrian L., Paul M McSheehy   +66 more
core   +2 more sources

Glycolysis-related genes from the REACTOME_GLYCOLYSIS.

, 2022
(DOCX)
Reeree Lee (13889369), Wonshik Han (6448), Ju Won Seok (13889375), Hongyoon Choi (541919), Han-Byoel Lee (835487), Jin Chul Paeng (8203131), Wonseok Whi (13889372), Keon Wook Kang (177145), Gi Jeong Cheon (691224)   +8 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Enhanced glycolysis is associated with aggressive tumor phenotype and worse outcomes in hepatocellular carcinoma patients

Frontiers in Medicine
BackgroundAdenosine Triphosphate (ATP) is mainly generated by oxidative phosphorylation in non-malignant cells, whereas malignant cells rely predominantly on glycolysis for energy production, known as the “Warburg effect.” This study used the gene set ...
Masanori Oshi, Masanori Oshi, Colin Rog, Li Yan, Itaru Endo, Kazuaki Takabe, Kazuaki Takabe, Kazuaki Takabe, Kazuaki Takabe   +8 more
doaj   +1 more source

2-Deoxyglucose alleviates migraine-related behaviors by modulating microglial inflammatory factors in experimental model of migraine

Frontiers in Neurology, 2023
BackgroundTargeting metabolic pathways has emerged as a new migraine treatment strategy as researchers realize the critical role metabolism plays in migraine. Activated inflammatory cells undergo metabolic reprogramming and rely on glycolysis to function.
Tao Qiu, Yanjie Zhou, Luyu Hu, Zhengming Shan, Yu Zhang, Yuting Fang, Wanbin Huang, Lily Zhang, Shanghua Fan, Zheman Xiao   +9 more
doaj   +1 more source

Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9

Cancer Biology & Therapy
Background Lung cancer is the deadliest form of malignancy and the most common subtype is non-small cell lung cancer (NSCLC). Hypoxia is a typical feature of solid tumor microenvironment.
Fei Yan, Yue Teng, Xiao-You Li, Yuejiao Zhong, Chun-yi Li, Feng Yan, Xia He   +6 more
semanticscholar   +1 more source

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Molecular Oncology, 2020
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance.
Xin-Yi Wang, Haiyang Zhang, Haiou Yang, M. Bai, T. Ning, T. Deng, Rui Liu, Q. Fan, Kegan Zhu, Jia-Lu Li, Yang Zhan, G. Ying, Y. Ba   +12 more
semanticscholar   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source