Results 61 to 70 of about 339,187 (240)

Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer

Cell Death and Disease, 2022
Aerobic glycolysis (the Warburg effect) has been demonstrated to facilitate tumor progression by producing lactate, which has important roles as a proinflammatory and immunosuppressive mediator.
Huimin Jiang, Huimin Wei, Hang Wang, Zhaoyang Wang, Jianjun Li, Yang Ou, Xuesu Xiao, Wenhao Wang, Antao Chang, Wei Sun, Li Zhao, Shuang Yang   +11 more
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Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect [PDF]

, 2011
The Warburg effect - a classical hallmark of cancer metabolism - is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily ...
Tomer Shlomi, Eyal Gottlieb, Gottlieb, E., Shlomi, T., Gottlieb Eyal, Roded Sharan, Eytan Ruppin, Ruppin Eytan, Tomer Benyamini, Shlomi Tomer, Sharan Roded, Benyamini Tomer, Ruppin, E., Benyamini, T., Sharan, R.   +14 more
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Glycolysis under Circadian Control

, 2021
Glycolysis is considered a main metabolic pathway in highly proliferative cells, including endothelial, epithelial, immune, and cancer cells.
Jana Zlacká, Michal Zeman
core   +1 more source

Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9

Cancer Biology & Therapy
Background Lung cancer is the deadliest form of malignancy and the most common subtype is non-small cell lung cancer (NSCLC). Hypoxia is a typical feature of solid tumor microenvironment.
Fei Yan, Yue Teng, Xiaoyou Li, Yuejiao Zhong, Chun-yi Li, Feng Yan, Xia He   +6 more
semanticscholar   +1 more source

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

Molecules and Cells, 2021
SUMMARY R-2-hydroxyglutarate (R-2HG), a metabolite produced by mutant isocitrate dehydrogenases (IDH), was recently reported to exhibit anti-tumor activity. However, its effect on cancer metabolism remains largely elusive.
Y. Qing, Lei Dong, Lei Gao, Chenying Li, Yangchan Li, Li Han, Emily A. Prince, B. Tan, Xiaolan Deng, Collin Wetzel, Chao Shen, Min Gao, Zhenhua Chen, Wei Li, Bin Zhang, D. Braas, J. ten Hoeve, G. Sanchez, Huiying Chen, L. Chan, Chun-Wei Chen, D. Ann, Lei Jiang, M. Müschen, G. Marcucci, D. Plas, Zejuan Li, R. Su, Jianjun Chen   +28 more
semanticscholar   +1 more source

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes [PDF]

, 2013
peer reviewedWe present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a
Carroll, Kathleen M, Paton, Norman W, Mendes, Pedro, McCarthy, John E G, Carroll, K.M., Weichart, D., Broomhead, David S., Murabito, Ettore, Khan, Farid, Messiha, Hanan L.,, Dunn, Warwick B., Oliver, Stephen G,, Swainston, N., Broomhead, D. S., Dada, Joseph O., Oliver, Stephen G., Westerhoff, H.V.; id_orcid, Kell, Douglas B.,, Kell, D.B., Gaskell, Simon J, Winder, Catherine L., Malys, Naglis, Dada, J.O., Westerhoff, Hans V.,, Pir, P., Paton, N.W., Pendes, Pedro, Pir, Pınar,, Murabito, Ettore,, Messiha, H.L., Paton, Norman W., Westerhoff, Hans V., Gaskell, Simon J., Dunn, Warwick B.,, Simeonidis, E., Kell, Douglas B., Simeonidis, Evangelos,, Khan, Farid,, Jameson, Daniel; id_orcid, Gaskell, S.J., Jameson, Daniel, Dada, Joseph O, Carroll, Kathleen M.,, Spasić, I., Kell, Douglas B, Smallbone, K., Winder, Catherine L, Mendes, P., McCarthy, John E. G., Hayes, Neil W., Paton, Norman; id_orcid, Spasic, Irena, Weichart, Dieter, Pir, Pınar, Gaskell, S. J., Carroll, Kathleen M., Dunn, W.B., Jameson, Daniel,, Jameson, D., Gaskell, Simon J.,, Malys, N., Paton, Norman W.,, Malys, Naglis,, SIMEONIDIS, Vangelis, Smallbone, Kieran,, Simeonidis, Evangelos, Wishart, J., Messiha, Hanan L, Wishart, Jill,, Westerhoff, Hans V, McCarthy, John E G,, Murabito, E., Khan, F., Oliver, Stephen G, Wishart, Jill, Broomhead, David S, Messiha, Hanan L., Dunn, Warwick B, Winder, C.L., Jameson, D,, Dada, Joseph O.,, Swainston, Neil,, Weichart, Dieter,, Oliver, S. G., Hayes, N.W., Pir, Pinar, Spasić, Irena,, Broomhead, D.S., Mendes, Pedro,, Broomhead, David S.,, McCarthy, John E.G., Hayes, Neil W, Hayes, Neil W.,, Oliver, S.G., Swainston, Neil, Smallbone, Kieran, McCarthy, J.E.G., Winder, Catherine L.,, Westerhoff, H.V., Carroll, Kathleen M; id_orcid   +99 more
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Image_2_Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit.tif

, 2021
Tumor-associated macrophages (TAMs), which display a tumor-supportive M2 phenotype, are closely related to tumor growth and metastasis. The reprogramming of TAMs toward a tumoricidal M1 profile has emerged as an attractive strategy for cancer ...
Jing Qiu (273902), Kebin Zhang (773363), Ying Bai (107853), Qian Dai (2640862), Halei Sheng (9236807), Defeng Li (147787), Hong Zhang (25820), Xiaomei Hu (830022), Yuanyuan Li (18671), Le Zhang (88249), Lu Jiang (115479), Qiaoqiao Li (355362), Jin Peng (287324), Junzhi Xiong (9236804), Rong Xin (9236810), Qian Chen (18883), Xingmin Wang (2614936), Hua Yu (138267), Xiaomei He (795333)   +18 more
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CypA inhibits respiratory syncytial virus (RSV) replication by suppressing glycolysis through the downregulation of PKM2 expression

Journal of Virology
The “Warburg effect,” a type of metabolic reprogramming characterized by enhanced glycolysis even in the presence of oxygen, is frequently observed in tumor cells and has also been detected in cells infected with viruses.
Jing Zhang, Miao Li, Jing Cheng, Yutong Wang, Cuiqing Ma, Lizheng Yin, Jiachao Wang, Xue Gao, Wenzhang Liang, Lin Wei   +9 more
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Coxsackievirus B3 infection induces glycolysis to facilitate viral replication

Frontiers in Microbiology, 2022
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strategy against CVB3 is available. Viruses lack an inherent metabolic system and thus depend on host cellular metabolism for their benefit.
Yujie Qian, Yeyi Yang, Wenxiang Qing, Chunyun Li, Min Kong, Zhijuan Kang, Yuanbojiao Zuo, Jiping Wu, Meng Yu, Zuocheng Yang   +9 more
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The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer

Cancer Communications, 2021
As a rate‐limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2 (PKM2) participates in tumor metabolism and growth. The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer. The 5‐methylcytidine (m5C)
Jing-zi Wang, Wei Zhu, Jie Han, X. Yang, R. Zhou, Hongcheng Lu, Hao Yu, Wenbo Yuan, Pengchao Li, J. Tao, Q. Lu, Jifu Wei, Haiwei Yang   +12 more
semanticscholar   +1 more source