Results 61 to 70 of about 291,093 (299)
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Limits and Tradeoffs in the Control of Autocatalytic Systems [PDF]
, 2013 Despite the complexity of biological networks, we find that certain common architectures govern network structures. These architectures impose fundamental constraints on system performance and create tradeoffs that the system must balance in the face of ...
Chandra, Fiona Adriani
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou +6 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez +9 more
wiley +1 more source
Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas [PDF]
, 2011 Background HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model.
Golinska Monika +50 more
core +2 more sources
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source
Phenylpropanoid and glycolysis/gluconeogenesis pathway related DEGs.
, 2022 (A) Map of glycolysis/gluconeogenesis pathway; (B) Gene clustering heat map participating in the glycolysis/gluconeogenesis pathway; (C) Map of phenylpropanoid pathway; (D): Gene clustering heat map involving in the phenylpropanoid pathway.
Yuxiang Wang (154616) +7 more
core +1 more source
Advanced Science, EarlyView.Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong +20 more
wiley +1 more source
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect [PDF]
, 2011 The Warburg effect - a classical hallmark of cancer metabolism - is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily ...
Tomer Shlomi +14 more
core +1 more source
, 2022 SUVmax was well correlated with glycolysis score (A). A negative correlation between AR expression and SUVmax was observed (B). The AR expression is inversely correlated with glycolysis score (C).
Reeree Lee (13889369) +8 more
core +1 more source