Results 1 to 10 of about 1,034,096 (317)

Isolation and characterization of exosomes for cancer research

Journal of Hematology & Oncology, 2020
Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins, nucleic acids, metabolites, and lipids. Mounting evidence suggests that exosomes participate in intercellular communication and act as important molecular ...
Le Zhu, Hao-Ting Sun, Shun Wang, Sheng-Lin Huang, Yan Zheng, Chao-Qun Wang, Bei-Yuan Hu, Wei Qin, Tian-Tian Zou, Yan Fu, Xiao-Tian Shen, Wen-Wei Zhu, Yan Geng, Lu Lu, Hu-liang Jia, Lun-Xiu Qin, Qiong-Zhu Dong   +16 more
doaj   +1 more source

Publisher Correction: Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Xiaodong Xie, Huifang Nie, Yu Zhou, Shu Lian, Hao Mei, Yusheng Lu, Haiyan Dong, Fengqiao Li, Tao Li, Bifei Li, Jie Wang, Min Lin, Chaihung Wang, Jingwei Shao, Yu Gao, Jianming Chen, Fangwei Xie, Lee Jia   +17 more
doaj   +1 more source

GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages

Signal Transduction and Targeted Therapy, 2021
The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC) progression and metastasis.
Jinhong Chen, Zhifei Lin, Lu Liu, Rui Zhang, Yan Geng, Minghao Fan, Wenwei Zhu, Ming Lu, Lu Lu, Huliang Jia, Jubo Zhang, Lun-Xiu Qin   +11 more
doaj   +1 more source

AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Journal of Experimental & Clinical Cancer Research, 2022
Background Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization.
Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang, Jinhong Chen   +12 more
doaj   +1 more source

Redox/NIR dual-responsive MoS2 for synergetic chemo-photothermal therapy of cancer

Journal of Nanobiotechnology, 2019
Background The construction of a multifunctional drug delivery system with a variety of advantageous features, including targeted delivery, controlled release and combined therapy, is highly attractive but remains a challenge.
Jian Liu, Feiyang Li, Junxia Zheng, Bifei Li, Doudou Zhang, Lee Jia   +5 more
doaj   +1 more source

Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer

Journal of Immunology Research, 2022
Prostate cancer (PCa) is recognized as a common malignancy in male patients. The homeobox A cluster (HOXA) family members have been confirmed to be implicated in the development of several types of tumors.
Yan-ping Song, Peng Xian, Hong Luo, Jun-yong Dai, Yu Bai, Yuan Li, Xian-li Tang   +6 more
doaj   +1 more source

Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3

Signal Transduction and Targeted Therapy, 2021
Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how these cancer cells interact with each other is still largely unknown.
Haoting Sun, Chaoqun Wang, Beiyuan Hu, Xiaomei Gao, Tiantian Zou, Qin Luo, Mo Chen, Yan Fu, Yuanyuan Sheng, Kaili Zhang, Yan Zheng, Xudong Ren, Shican Yan, Yan Geng, Luyu Yang, Qiongzhu Dong, Lunxiu Qin   +16 more
doaj   +1 more source

Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype

iScience, 2021
Summary: Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic resistance to ICB is a major clinical challenge.
Xue Hao, Bo Zhao, Wei Zhou, Heng Liu, Takeshi Fukumoto, Dmitry Gabrilovich, Rugang Zhang   +6 more
doaj   +1 more source

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

Nature Communications, 2021
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang   +13 more
doaj   +1 more source

Evolution from small molecule to nano-drug delivery systems: An emerging approach for cancer therapy of ursolic acid

Asian Journal of Pharmaceutical Sciences, 2020
Ursolic acid (UA), a natural pentacyclic triterpenoid, possesses widespread biological and pharmacological activities. However, drawbacks such as low bioavailability, poor targeting and rapid metabolism greatly hinder its further clinical application ...
Jingwei Shao, Yifan Fang, Ruirui Zhao, Fangmin Chen, Mingyue Yang, Jiali Jiang, Zixuan Chen, Xiaotian Yuan, Lee Jia   +8 more
doaj   +1 more source