Results 1 to 10 of about 1,603,424 (366)

Metastasis

Cell, 2023
SUMMARY Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still emerging.
Stefanie Gerstberger, Qingwen Jiang, K. Ganesh   +2 more
semanticscholar   +3 more sources

Isolation and characterization of exosomes for cancer research

Journal of Hematology & Oncology, 2020
Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins, nucleic acids, metabolites, and lipids. Mounting evidence suggests that exosomes participate in intercellular communication and act as important molecular ...
Le Zhu, Hao-Ting Sun, Shun Wang, Sheng-Lin Huang, Yan Zheng, Chao-Qun Wang, Bei-Yuan Hu, Wei Qin, Tian-Tian Zou, Yan Fu, Xiao-Tian Shen, Wen-Wei Zhu, Yan Geng, Lu Lu, Hu-liang Jia, Lun-Xiu Qin, Qiong-Zhu Dong   +16 more
doaj   +1 more source

Publisher Correction: Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Xiaodong Xie, Huifang Nie, Yu Zhou, Shu Lian, Hao Mei, Yusheng Lu, Haiyan Dong, Fengqiao Li, Tao Li, Bifei Li, Jie Wang, Min Lin, Chaihung Wang, Jingwei Shao, Yu Gao, Jianming Chen, Fangwei Xie, Lee Jia   +17 more
doaj   +1 more source

GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages

Signal Transduction and Targeted Therapy, 2021
The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC) progression and metastasis.
Jinhong Chen, Zhifei Lin, Lu Liu, Rui Zhang, Yan Geng, Minghao Fan, Wenwei Zhu, Ming Lu, Lu Lu, Huliang Jia, Jubo Zhang, Lun-Xiu Qin   +11 more
doaj   +1 more source

AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Journal of Experimental & Clinical Cancer Research, 2022
Background Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization.
Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang, Jinhong Chen   +12 more
doaj   +1 more source

The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Journal of Hematology & Oncology, 2022
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis,
Yuhe Huang, Weiqi Hong, Xiawei Wei
semanticscholar   +1 more source

Redox/NIR dual-responsive MoS2 for synergetic chemo-photothermal therapy of cancer

Journal of Nanobiotechnology, 2019
Background The construction of a multifunctional drug delivery system with a variety of advantageous features, including targeted delivery, controlled release and combined therapy, is highly attractive but remains a challenge.
Jian Liu, Feiyang Li, Junxia Zheng, Bifei Li, Doudou Zhang, Lee Jia   +5 more
doaj   +1 more source

Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer

Journal of Immunology Research, 2022
Prostate cancer (PCa) is recognized as a common malignancy in male patients. The homeobox A cluster (HOXA) family members have been confirmed to be implicated in the development of several types of tumors.
Yan-ping Song, Peng Xian, Hong Luo, Jun-yong Dai, Yu Bai, Yuan Li, Xian-li Tang   +6 more
doaj   +1 more source

Tumour exosome integrins determine organotropic metastasis

Nature, 2015
Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident ...
Ayuko Hoshino, B. Costa-Silva, Tang-Long Shen, G. Rodrigues, Ayako Hashimoto, M. T. Mark, H. Molina, S. Kohsaka, Angela Di Giannatale, S. Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, K. Uryu, Lindsay A. Pharmer, T. King, L. Bojmar, A. E. Davies, Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan M. Hernandez, Joshua M. Weiss, Vanessa D. Dumont-Cole, K. Kramer, L. Wexler, A. Narendran, G. Schwartz, J. Healey, P. Sandstrom, K. Labori, E. Kure, P. Grandgenett, M. Hollingsworth, Maria de Sousa, S. Kaur, Maneesh Jain, K. Mallya, S. Batra, W. Jarnagin, M. Brady, O. Fodstad, V. Muller, K. Pantel, A. Minn, M. Bissell, B. Garcia, Yibin Kang, Vinagolu K. Rajasekhar, Cyrus M. Ghajar, Irina R Matei, H. Peinado, J. Bromberg, D. Lyden   +53 more
semanticscholar   +1 more source

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Nature Communications, 2020
Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling.
Juliane Winkler, A. Abisoye-Ogunniyan, K. J. Metcalf, Z. Werb   +3 more
semanticscholar   +1 more source