Results 41 to 50 of about 1,603,424 (366)
Nature Communications, 2019 Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate ...
Xiaodong Xie +17 more
doaj +1 more source
Breast Cancer Metastasis: Mechanisms and Therapeutic Implications
International Journal of Molecular Sciences, 2022 Breast cancer is the most common malignancy in women worldwide. Metastasis is the leading cause of high mortality in most cancers. Although predicting the early stage of breast cancer before metastasis can increase the survival rate, breast cancer is ...
Misung Park +5 more
semanticscholar +1 more source
STAR Protocols, 2023 Summary: Organotypic brain cultures are short-term assays that phenotypically and functionally recapitulate brain metastatic cells in vivo. Here, we present a protocol to generate murine organotypic brain cultures for drug screening.
Lucía Zhu +4 more
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Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
Nature Communications, 2017 The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific.
Martin Teichert +13 more
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Tumor Metastasis: Molecular Insights and Evolving Paradigms
Cell, 2011 Metastases represent the end-products of a multi-step cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue ...
Scott Valastyan, R. Weinberg
semanticscholar +1 more source
Mitochondrial RNA modifications shape metabolic plasticity in metastasis
Nature, 2022 Aggressive and metastatic cancers show enhanced metabolic plasticity1, but the precise underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA methyltransferase 3 (NSUN3)-dependent RNA modifications—5-methylcytosine (m5C) and its ...
S. Delaunay +13 more
semanticscholar +1 more source
LincRNA01703 Facilitates CD81+ Exosome Secretion to Inhibit Lung Adenocarcinoma Metastasis via the Rab27a/SYTL1/CD81 Complex [PDF]
, 2023 Metastasis, a major cause of cancer-related mortality worldwide, frequently occurs early in the diagnosis of lung adenocarcinoma (LUAD). However, the precise molecular mechanisms governing the aggressive metastatic behavior of LUAD remain incompletely ...
Junchao Cai +13 more
core +1 more source
Oncogene, 2022 Metastasis is an important factor contributing to poor prognosis in patients with gastric cancer; yet, the molecular mechanism leading to this cell behavior is still not well understood.
Dongbao Li +12 more
semanticscholar +1 more source
Invasion and metastasis in cancer: molecular insights and therapeutic targets
Signal Transduction and Targeted TherapyThe progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting their quality of
Yongxing Li +6 more
semanticscholar +1 more source
The metabolism of cancer cells during metastasis
Nature Reviews. Cancer, 2021 Metastasis formation is the major cause of death in most patients with cancer. Despite extensive research, targeting metastatic seeding and colonization is still an unresolved challenge.
G. Bergers, S. Fendt
semanticscholar +1 more source