Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells [PDF]
Redox Biology, 2022 Myoferlin, an emerging oncoprotein, has been associated with a low survival in several cancer types including pancreas ductal adenocarcinoma where it controls mitochondria structure and respiratory functions.
Gilles Rademaker +2 more
exaly +7 more sources
Myoferlin disturbs redox equilibrium to accelerate gastric cancer migration [PDF]
Frontiers in Oncology, 2022 ObjectiveIn contrast to normal cells, in which reactive oxygen species (ROS) are maintained in redox equilibrium, cancer cells are characterized by ectopic ROS accumulation.
Hailong Shi +8 more
doaj +4 more sources
Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma [PDF]
Journal of Pathology and Translational Medicine, 2022 Background Myoferlin is a multifunctional protein expressed in various normal and cancer cells, with novel oncogenic roles being newly discovered. Recently, correlations have been found between myoferlin expression and unfavorable prognosis in various ...
Ji Min Na +8 more
doaj +4 more sources
Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts [PDF]
The EMBO JournalPancreatic adenocarcinoma (PAAD) cells exploit vesicle trafficking proteins, such as myoferlin (encoded by MYOF), to fuel tumor aggressiveness, yet the presence and function of myoferlin-dependent vesicles in cancer-associated fibroblasts (CAFs) remain ...
Raphaël Peiffer +14 more
doaj +3 more sources
A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression [PDF]
Clinical and Translational Medicine, 2021 As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain enigmatic, and MYOF‐targeted therapy in this malignancy has not been explored.
Yuan He, Yunqi Li, Haijun Gu
exaly +4 more sources
Focal adhesion assembly and cell migration require myoferlin in PDAC cell lines [PDF]
Scientific ReportsPancreatic ductal adenocarcinoma (PDAC) has a dire prognosis due to late diagnosis and ineffective treatments. Myoferlin, a transmembrane protein, is overexpressed in PDAC and correlates with poor patient survival, making it a potential therapeutic ...
Charlotte Gullo +11 more
doaj +3 more sources
Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines [PDF]
Cell Communication and SignalingBackground Pancreatic ductal adenocarcinoma is an aggressive cancer type with one of the lowest survival rates due to late diagnosis and the absence of effective treatments.
Sandy Anania +8 more
doaj +2 more sources
Otoferlin as a multirole Ca2+ signaling protein: from inner ear synapses to cancer pathways [PDF]
Frontiers in Cellular Neuroscience, 2023 Humans have six members of the ferlin protein family: dysferlin, myoferlin, otoferlin, fer1L4, fer1L5, and fer1L6. These proteins share common features such as multiple Ca2+-binding C2 domains, FerA domains, and membrane anchoring through their single C ...
Jean-Christophe Leclère +3 more
doaj +2 more sources
Identification of Myoferlin, a Potential Serodiagnostic Antigen of Clonorchiasis, via Immunoproteomic Analysis of Sera From Different Infection Periods and Excretory-Secretory Products of Clonorchis sinensis [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Clonorchiasis, which is caused by Clonorchis sinensis, is an important foodborne disease worldwide. The excretory-secretory products (ESPs) of C. sinensis play important roles in host-parasite interactions by acting as causative agents.
Xiao-Xiao Ma +11 more
doaj +2 more sources
Recurrent angioedema manifestation and treatment response in two patients from different families caring the myoferlin gene mutation: case series [PDF]
Orphanet Journal of Rare DiseasesData on hereditary angioedema with normal C1 inhibitor levels are currently limited. To date, only one Italian family with HAE-MYOF has been described, comprising exclusively female members.
Daria S. Fomina +12 more
doaj +2 more sources