Results 1 to 10 of about 79 (74)
Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells
Redox Biology, 2022 Myoferlin, an emerging oncoprotein, has been associated with a low survival in several cancer types including pancreas ductal adenocarcinoma where it controls mitochondria structure and respiratory functions.
Gilles Rademaker +2 more
exaly +3 more sources
Myoferlin disturbs redox equilibrium to accelerate gastric cancer migration
Frontiers in Oncology, 2022 ObjectiveIn contrast to normal cells, in which reactive oxygen species (ROS) are maintained in redox equilibrium, cancer cells are characterized by ectopic ROS accumulation.
Hailong Shi +2 more
exaly +3 more sources
Clinical and Translational Medicine, 2021 As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain enigmatic, and MYOF‐targeted therapy in this malignancy has not been explored.
Yuan He, Yunqi Li, Haijun Gu
exaly +2 more sources
Focal adhesion assembly and cell migration require myoferlin in PDAC cell lines
Scientific ReportsPancreatic ductal adenocarcinoma (PDAC) has a dire prognosis due to late diagnosis and ineffective treatments. Myoferlin, a transmembrane protein, is overexpressed in PDAC and correlates with poor patient survival, making it a potential therapeutic ...
Ferman Agirman +2 more
exaly +2 more sources
EMBO JournalPancreatic adenocarcinoma (PAAD) cells exploit vesicle trafficking proteins, such as myoferlin (encoded by MYOF), to fuel tumor aggressiveness, yet the presence and function of myoferlin-dependent vesicles in cancer-associated fibroblasts (CAFs) remain ...
Naima Maloujahmoum +2 more
exaly +2 more sources
Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma [PDF]
Journal of Pathology and Translational Medicine, 2022 Background Myoferlin is a multifunctional protein expressed in various normal and cancer cells, with novel oncogenic roles being newly discovered. Recently, correlations have been found between myoferlin expression and unfavorable prognosis in various ...
Ji Min Na +8 more
doaj +1 more source
Myoferlin Expression and Its Correlation with FIGO Histologic Grading in Early-Stage Endometrioid Carcinoma [PDF]
Journal of Pathology and Translational Medicine, 2018 Background For endometrioid carcinoma patients, International Federation of Gynecologists and Obstetricians (FIGO) histologic grading is very important for identifying the appropriate treatment method.
Min Hye Kim +8 more
doaj +1 more source
Scientific Reports, 2021 Muscular dystrophies are disorders characterized by progressive muscle loss and weakness that are both genotypically and phenotypically heterogenous. Progression of muscle disease arises from impaired regeneration, plasma membrane instability, defective ...
David Y. Barefield +5 more
doaj +1 more source
Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression. [PDF]
PLoS ONE, 2012 Normal airway epithelial barrier function is maintained by cell-cell contacts which require the translocation of adhesion proteins at the cell surface, through membrane vesicle trafficking and fusion events.
Cleo Leung +3 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Clonorchiasis, which is caused by Clonorchis sinensis, is an important foodborne disease worldwide. The excretory-secretory products (ESPs) of C. sinensis play important roles in host-parasite interactions by acting as causative agents.
Xiao-Xiao Ma +11 more
doaj +1 more source