HBZ upregulates myoferlin expression to facilitate HTLV-1 infection.
PLoS Pathogens, 2023 The complex retrovirus, human T-cell leukemia virus type 1 (HTLV-1), primarily infects CD4+ T-cells in vivo. Infectious spread within this cell population requires direct contact between virally-infected and target cells.
Nicholas Polakowski +9 more
doaj +4 more sources
Characterization Analysis of Schistosoma japonicum Plasma Membrane Repair Relative Gene Myoferlin. [PDF]
PLoS ONE, 2013 Myoferlin is a member of the ferlin family of proteins, which are involved in plasma membrane repair, and has been identified as one of the tegument proteins of Schistosoma japonicum.
Yanian Xiong +10 more
doaj +4 more sources
Myoferlin is a component of late-stage vRNP trafficking vesicles for enveloped RNA viruses [PDF]
Nature CommunicationsThe Rab11 endosomal recycling pathway is exploited by important respiratory RNA viruses such as IAV and RSV, aiding viral egress from the apical surface of polarized epithelial cells.
Stefano Bonazza +11 more
doaj +2 more sources
Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function. [PDF]
PLoS ONE, 2022 Ferlins are complex, multi-domain proteins, involved in membrane trafficking, membrane repair, and exocytosis. The large size of ferlin proteins and the lack of consensus regarding domain boundaries have slowed progress in understanding molecular-level ...
Matthew J Dominguez +2 more
doaj +2 more sources
Myoferlin Expression and Its Correlation with FIGO Histologic Grading in Early-Stage Endometrioid Carcinoma [PDF]
Journal of Pathology and Translational Medicine, 2018 Background For endometrioid carcinoma patients, International Federation of Gynecologists and Obstetricians (FIGO) histologic grading is very important for identifying the appropriate treatment method.
Min Hye Kim +8 more
doaj +3 more sources
Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion. [PDF]
PLoS ONE, 2012 Myoferlin (MYOF) is a mammalian ferlin protein with homology to ancestral Fer-1, a nematode protein that regulates spermatic membrane fusion, which underlies the amoeboid-like movements of its sperm.
Ruth Li +5 more
doaj +6 more sources
In silico analysis of the oncogenic role of myoferlin (MYOF) and suggestion of folate as a potential therapeutic for brain cancer in the Caucasian population [PDF]
Discover OncologyBackground Myoferlin (MYOF), a key gene in endocytosis, is known to be crucial for metastasis in cancer. While the involvement of MYOF as a biomarker is documented in cancer, a comprehensive study on its knockdown for targeted therapy via folate is a ...
Saanvi Muthuchetty
doaj +2 more sources
Structural insights into lipid membrane binding by human ferlins [PDF]
The EMBO JournalFerlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion.
Constantin Cretu +6 more
doaj +2 more sources
Myoferlin alleviates pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting NLRP3-mediated pyroptosis [PDF]
PeerJMyoferlin (MYOF) is a muscle-derived secretory protein. Recent studies have found that MYOF protects against cell damage. However, the role of MYOF in cardiac hypertrophy remains unclear. Increasing evidence suggests that NLRP3 (NOD-like receptor protein
Yang Zhou +14 more
doaj +3 more sources
Loss of myoferlin redirects breast cancer cell motility towards collective migration.
PLoS ONE, 2014 Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal transition (EMT) and migrate as single cells.
Leonithas I Volakis +11 more
doaj +3 more sources