Results 11 to 20 of about 1,180 (165)

Myoferlin is a component of late-stage vRNP trafficking vesicles for enveloped RNA viruses [PDF]

Nature Communications
The Rab11 endosomal recycling pathway is exploited by important respiratory RNA viruses such as IAV and RSV, aiding viral egress from the apical surface of polarized epithelial cells.
Stefano Bonazza, Hannah L. Turkington, Swathi Sukumar, Emily Peate, Hannah L. Coutts, Joshua J. Montgomery, Courtney Hawthorn, Erin M. P. E. Getty, Olivier Touzelet, Judit Barabas, Ultan F. Power, David G. Courtney   +11 more
doaj   +5 more sources

Characterization Analysis of Schistosoma japonicum Plasma Membrane Repair Relative Gene Myoferlin. [PDF]

PLoS ONE, 2013
Myoferlin is a member of the ferlin family of proteins, which are involved in plasma membrane repair, and has been identified as one of the tegument proteins of Schistosoma japonicum.
Yanian Xiong, Ming Zhang, Yang Hong, Meimei Wei, Dezhou Ai, Peipei Meng, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jianmei Yang, Jiaojiao Lin   +10 more
doaj   +5 more sources

Myoferlin regulation by NFAT in muscle injury, regeneration and repair [PDF]

Journal of Cell Science, 2010
Ferlin proteins mediate membrane-fusion events in response to Ca2+. Myoferlin, a member of the ferlin family, is required for normal muscle development, during which it mediates myoblast fusion. We isolated both damaged and intact myofibers from a mouse model of muscular dystrophy using laser-capture microdissection and found that the levels of ...
Alexis R, Demonbreun, Karen A, Lapidos, Konstantina, Heretis, Samantha, Levin, Rodney, Dale, Peter, Pytel, Eric C, Svensson, Elizabeth M, McNally   +7 more
openaire   +3 more sources

Myoferlin Is a Key Regulator of EGFR Activity in Breast Cancer [PDF]

Cancer Research, 2013
Abstract Myoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair, and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its expression in and contributions to cancer are not well established.
Turtoi, Andrei, Blomme, Arnaud, Bellahcene, Akeila, Gilles, Christine, Hennequière, Vincent, Peixoto, Paul, BIANCHI, Elettra, Noël, Agnès, De Pauw, Edwin, LIFRANGE, Eric, Delvenne, Philippe, Castronovo, Vincenzo   +11 more
openaire   +5 more sources

HBZ upregulates myoferlin expression to facilitate HTLV-1 infection.

PLoS Pathogens, 2023
The complex retrovirus, human T-cell leukemia virus type 1 (HTLV-1), primarily infects CD4+ T-cells in vivo. Infectious spread within this cell population requires direct contact between virally-infected and target cells.
Nicholas Polakowski, Md Abu Kawsar Sarker, Kimson Hoang, Georgina Boateng, Amanda W Rushing, Wesley Kendle, Claudine Pique, Patrick L Green, Amanda R Panfil, Isabelle Lemasson   +9 more
doaj   +4 more sources

Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes [PDF]

Oncotarget, 2016
Exosomes are communication mediators participating in the intercellular exchange of proteins, metabolites and nucleic acids. Recent studies have demonstrated that exosomes are characterized by a unique proteomic composition that is distinct from the cellular one.
Blomme, Arnaud, Fahmy, Karim, Peulen, Olivier, Costanza, Brunella, Fontaine, Marie, Struman, Ingrid, Baiwir, Dominique, De Pauw, Edwin, Thiry, Marc, Bellahcene, Akeila, Castronovo, Vincenzo, Turtoi, Andrei   +11 more
openaire   +4 more sources

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies [PDF]

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +2 more sources

Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion. [PDF]

PLoS ONE, 2012
Myoferlin (MYOF) is a mammalian ferlin protein with homology to ancestral Fer-1, a nematode protein that regulates spermatic membrane fusion, which underlies the amoeboid-like movements of its sperm.
Ruth Li, William E Ackerman, Cosmin Mihai, Leonithas I Volakis, Samir Ghadiali, Douglas A Kniss   +5 more
doaj   +2 more sources

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth [PDF]

Nature Cell Biology, 2021
Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their lumen. Pancreatic cancer cells upregulate lysosomal biogenesis to enhance nutrient recycling and stress resistance, but it is unknown whether dedicated programmes for maintaining the integrity ...
Gupta, Suprit, Yano, Julian, Mercier, Vincent, Htwe, Htet Htwe, Shin, Hijai R, Rademaker, Gilles, Cakir, Zeynep, Ituarte, Thomas, Wen, Kwun W, Kim, Grace E, Zoncu, Roberto, Roux, Aurélien, Dawson, David W, Perera, Rushika M   +13 more
openaire   +5 more sources

Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines [PDF]

Cell Communication and Signaling
Background Pancreatic ductal adenocarcinoma is an aggressive cancer type with one of the lowest survival rates due to late diagnosis and the absence of effective treatments.
Sandy Anania, Martin Farnir, Raphaël Peiffer, Yasmine Boumahd, Marc Thiry, Ferman Agirman, Naima Maloujahmoum, Akeila Bellahcène, Olivier Peulen   +8 more
doaj   +2 more sources