Results 11 to 20 of about 1,181 (166)

Myoferlin Expression and Its Correlation with FIGO Histologic Grading in Early-Stage Endometrioid Carcinoma [PDF]

Journal of Pathology and Translational Medicine, 2018
Background For endometrioid carcinoma patients, International Federation of Gynecologists and Obstetricians (FIGO) histologic grading is very important for identifying the appropriate treatment method.
Min Hye Kim, Dae Hyun Song, Gyung Hyuck Ko, Jeong Hee Lee, Dong Chul Kim, Jung Wook Yang, Hyang Im Lee, Hyo Jung An, Jong Sil Lee   +8 more
doaj   +5 more sources

A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression [PDF]

Clinical and Translational Medicine, 2021
As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain enigmatic, and MYOF‐targeted therapy in this malignancy has not been explored.
Mingyao Liu, Yuan He, Yunqi Li
exaly   +4 more sources

Characterization Analysis of Schistosoma japonicum Plasma Membrane Repair Relative Gene Myoferlin. [PDF]

PLoS ONE, 2013
Myoferlin is a member of the ferlin family of proteins, which are involved in plasma membrane repair, and has been identified as one of the tegument proteins of Schistosoma japonicum.
Yanian Xiong, Ming Zhang, Yang Hong, Meimei Wei, Dezhou Ai, Peipei Meng, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jianmei Yang, Jiaojiao Lin   +10 more
doaj   +6 more sources

c-Met and EPHA7 Receptor Tyrosine Kinases Are Related to Prognosis in Clear Cell Renal Cell Carcinoma: Focusing on the Association with Myoferlin Expression [PDF]

Cancers, 2022
Receptor tyrosine kinases (RTKs) are important targets for clear cell renal cell carcinoma (ccRCC) treatment. Myoferlin is a strong regulator of RTKs. To identify myoferlin-associated RTKs and their prognostic implications in ccRCC, we investigated the ...
Kyung Chul Moon, Minsun Jung, Seokhyeon Lee   +2 more
exaly   +7 more sources

Myoferlin regulation by NFAT in muscle injury, regeneration and repair [PDF]

Journal of Cell Science, 2010
Ferlin proteins mediate membrane-fusion events in response to Ca2+. Myoferlin, a member of the ferlin family, is required for normal muscle development, during which it mediates myoblast fusion. We isolated both damaged and intact myofibers from a mouse model of muscular dystrophy using laser-capture microdissection and found that the levels of ...
Alexis R, Demonbreun, Karen A, Lapidos, Konstantina, Heretis, Samantha, Levin, Rodney, Dale, Peter, Pytel, Eric C, Svensson, Elizabeth M, McNally   +7 more
openaire   +4 more sources

Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression. [PDF]

PLoS ONE, 2012
Normal airway epithelial barrier function is maintained by cell-cell contacts which require the translocation of adhesion proteins at the cell surface, through membrane vesicle trafficking and fusion events.
Cleo Leung, Furquan Shaheen, Pascal Bernatchez, Tillie-Louise Hackett   +3 more
doaj   +3 more sources

Myoferlin Is a Key Regulator of EGFR Activity in Breast Cancer [PDF]

Cancer Research, 2013
Abstract Myoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair, and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its expression in and contributions to cancer are not well established.
Turtoi, Andrei, Blomme, Arnaud, Bellahcene, Akeila, Gilles, Christine, Hennequière, Vincent, Peixoto, Paul, BIANCHI, Elettra, Noël, Agnès, De Pauw, Edwin, LIFRANGE, Eric, Delvenne, Philippe, Castronovo, Vincenzo   +11 more
openaire   +6 more sources

HBZ upregulates myoferlin expression to facilitate HTLV-1 infection.

PLoS Pathogens, 2023
The complex retrovirus, human T-cell leukemia virus type 1 (HTLV-1), primarily infects CD4+ T-cells in vivo. Infectious spread within this cell population requires direct contact between virally-infected and target cells.
Nicholas Polakowski, Md Abu Kawsar Sarker, Kimson Hoang, Georgina Boateng, Amanda W Rushing, Wesley Kendle, Claudine Pique, Patrick L Green, Amanda R Panfil, Isabelle Lemasson   +9 more
doaj   +4 more sources

Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes [PDF]

Oncotarget, 2016
Exosomes are communication mediators participating in the intercellular exchange of proteins, metabolites and nucleic acids. Recent studies have demonstrated that exosomes are characterized by a unique proteomic composition that is distinct from the cellular one.
Blomme, Arnaud, Fahmy, Karim, Peulen, Olivier, Costanza, Brunella, Fontaine, Marie, Struman, Ingrid, Baiwir, Dominique, De Pauw, Edwin, Thiry, Marc, Bellahcene, Akeila, Castronovo, Vincenzo, Turtoi, Andrei   +11 more
openaire   +5 more sources

Dysferlin and Myoferlin Regulate Transverse Tubule Formation and Glycerol Sensitivity [PDF]

The American Journal of Pathology, 2014
Dysferlin is a membrane-associated protein implicated in muscular dystrophy and vesicle movement and function in muscles. The precise role of dysferlin has been debated, partly because of the mild phenotype in dysferlin-null mice (Dysf). We bred Dysf mice to mice lacking myoferlin (MKO) to generate mice lacking both myoferlin and dysferlin (FER).
Demonbreun, Alexis R., Rossi, Ann E., Alvarez, Manuel G., Swanson, Kaitlin E., Deveaux, H. Kieran, Earley, Judy U., Hadhazy, Michele, Vohra, Ravneet, Walter, Glenn A., Pytel, Peter, McNally, Elizabeth M.   +10 more
openaire   +3 more sources