Results 21 to 30 of about 1,884 (173)

Myoferlin is a key regulator of EGFR activity in breast cancer. [PDF]

Cancer Research, 2013
peer reviewedMyoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its expression in and contributions to cancer ...
Turtoi, Andrei, Blomme, Arnaud, Bellahcene, Akeila, Gilles, Christine, Hennequière, Vincent, Peixoto, Paul, BIANCHI, Elettra, Noël, Agnès, De Pauw, Edwin, LIFRANGE, Eric, Delvenne, Philippe, Castronovo, Vincenzo   +11 more
core   +5 more sources

Managing Diagnosis, Treatment, and Burden of Disease in Hereditary Angioedema Patients with Normal C1-Esterase Inhibitor [PDF]

Journal of Asthma and Allergy, 2023
Douglas Jones,1 Heidi Zafra,2 John Anderson3 1Rocky Mountain Allergy, Tanner Clinic, Layton, UT, USA; 2Division of Allergy and Clinical Immunology, Medical College of Wisconsin, Milwaukee, WI, USA; 3AllerVie Health, Birmingham, AL, USACorrespondence ...
Jones D, Zafra H, Anderson J
doaj   +2 more sources

A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer [PDF]

Nature Communications, 2018
Improved therapeutics are needed for treating breast cancer. Here they show the druggability of myoferlin with a small molecule inhibitor in breast cancer and demonstrate its anti-breast cancer effects in vitro and in vivo.
Tao Zhang, Jingjie Li, Yuan He, Feifei Yang, Yun Hao, Wangrui Jin, Jing Wu, Zhenliang Sun, Yunqi Li, Yihua Chen, Zhengfang Yi, Mingyao Liu   +11 more
doaj   +3 more sources

Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis [PDF]

Oncogenesis, 2023
Gilles Rademaker, Brunella Costanza, Justine Bellier, Michael Herfs, Raphaël Peiffer, Ferman Agirman, Naïma Maloujahmoum, Yvette Habraken, Philippe Delvenne, Akeila Bellahcène, Vincent Castronovo, Olivier Peulen   +11 more
doaj   +2 more sources

Status quo and future developments in the diagnosis and treatment of hereditary angioedema. [PDF]

J Dtsch Dermatol Ges
Summary Hereditary angioedema (HAE) is a rare hereditary disease characterized by edema, which can be life‐threatening in case of swelling in the larynx. The most common form of HAE is caused by a mutation of the SERPING1 gene and is characterized by a deficiency (type I) or loss of function (type II) of the C1 inhibitor (C1‐INH), leading to excessive ...
Recke A.
europepmc   +2 more sources

Comprehensive Analysis of Myoferlin in Human Pancreatic Cancer via Bioinformatics [PDF]

BioMed Research International, 2021
Pancreatic cancer is the fourth leading cause of cancer‐related death and urgently needs biomarkers for clinical diagnosis and prognosis. It has been reported that myoferlin (MYOF) is implicated in the regulation of proliferation, invasion, and migration of tumor cells in many cancers including pancreatic cancer. To confirm the prognostic value of MYOF
Rou Pi, Yanmei Chen, Yijie Du, Suzhen Dong   +3 more
openaire   +2 more sources

Myoferlin, a Membrane Protein with Emerging Oncogenic Roles [PDF]

BioMed Research International, 2019
Myoferlin (MYOF), initially identified in muscle cells, is a member of the Ferlin family involved in membrane fusion, membrane repair, and membrane trafficking. Dysfunction of this protein is associated with muscular dysfunction. Recently, a growing body of studies have identified MYOF as an oncogenic protein.
Yimin Dong, Honglei Kang, Huiyong Liu, Jia Wang, Qian Guo, Chao Song, Yunlong Sun, Ya Zhang, Honghua Zhang, Zheng Zhang, Hanfeng Guan, Zhong Fang, Feng Li   +12 more
openaire   +3 more sources

Normal myoblast fusion requires myoferlin [PDF]

Development, 2005
Muscle growth occurs during embryonic development and continues in adult life as regeneration. During embryonic muscle growth and regeneration in mature muscle, singly nucleated myoblasts fuse to each other to form myotubes. In muscle growth, singly nucleated myoblasts can also fuse to existing large,syncytial myofibers as a mechanism of increasing ...
Katherine R, Doherty, Andrew, Cave, Dawn Belt, Davis, Anthony J, Delmonte, Avery, Posey, Judy U, Earley, Michele, Hadhazy, Elizabeth M, McNally   +7 more
openaire   +2 more sources

Loss of dysferlin or myoferlin results in differential defects in excitation–contraction coupling in mouse skeletal muscle

Scientific Reports, 2021
Muscular dystrophies are disorders characterized by progressive muscle loss and weakness that are both genotypically and phenotypically heterogenous. Progression of muscle disease arises from impaired regeneration, plasma membrane instability, defective ...
David Y. Barefield, Jordan J. Sell, Ibrahim Tahtah, Samuel D. Kearns, Elizabeth M. McNally, Alexis R. Demonbreun   +5 more
doaj   +1 more source

Lysosomal Repair in Health and Disease. [PDF]

J Cell Physiol
Lysosomes are essential for cellular stress clearance and overall organismal health. Lysosomal membrane damage is tightly linked to various pathologies, including aging, neurodegeneration, lysosomal storage disorders, and cardiovascular disease.
Xun J, Tan JX.
europepmc   +2 more sources