Recurrent angioedema manifestation and treatment response in two patients from different families caring the myoferlin gene mutation: case series [PDF]
Orphanet Journal of Rare DiseasesData on hereditary angioedema with normal C1 inhibitor levels are currently limited. To date, only one Italian family with HAE-MYOF has been described, comprising exclusively female members.
Daria S. Fomina +12 more
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Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth [PDF]
Nature Cell Biology, 2021 Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their lumen. Pancreatic cancer cells upregulate lysosomal biogenesis to enhance nutrient recycling and stress resistance, but it is unknown whether dedicated programmes for maintaining the integrity ...
Gupta, Suprit +13 more
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Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion. [PDF]
PLoS ONE, 2012 Myoferlin (MYOF) is a mammalian ferlin protein with homology to ancestral Fer-1, a nematode protein that regulates spermatic membrane fusion, which underlies the amoeboid-like movements of its sperm.
Ruth Li +5 more
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Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function. [PDF]
PLoS ONE, 2022 Ferlins are complex, multi-domain proteins, involved in membrane trafficking, membrane repair, and exocytosis. The large size of ferlin proteins and the lack of consensus regarding domain boundaries have slowed progress in understanding molecular-level ...
Matthew J Dominguez +2 more
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Structural insights into lipid membrane binding by human ferlins [PDF]
The EMBO JournalFerlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion.
Constantin Cretu +6 more
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In silico analysis of the oncogenic role of myoferlin (MYOF) and suggestion of folate as a potential therapeutic for brain cancer in the Caucasian population [PDF]
Discover OncologyBackground Myoferlin (MYOF), a key gene in endocytosis, is known to be crucial for metastasis in cancer. While the involvement of MYOF as a biomarker is documented in cancer, a comprehensive study on its knockdown for targeted therapy via folate is a ...
Saanvi Muthuchetty
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Apatinib Degrades PD-L1 and Reconstitutes Colon Cancer Microenvironment via the Regulation of Myoferlin [PDF]
CancersBackground: For most colorectal cancer (CRC) patients, expanding the benefits of immunotherapy, particularly through blocking programmed cell death-1 (PD-1) and its ligand (PD-L1), is crucial, especially in cases with limited response to neoadjuvant therapy.
Xiaoting Hong, Li Xiao, Tianhui Hu
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Myoferlin alleviates pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting NLRP3-mediated pyroptosis [PDF]
PeerJMyoferlin (MYOF) is a muscle-derived secretory protein. Recent studies have found that MYOF protects against cell damage. However, the role of MYOF in cardiac hypertrophy remains unclear. Increasing evidence suggests that NLRP3 (NOD-like receptor protein
Yang Zhou +14 more
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Managing Diagnosis, Treatment, and Burden of Disease in Hereditary Angioedema Patients with Normal C1-Esterase Inhibitor [PDF]
Journal of Asthma and Allergy, 2023 Douglas Jones,1 Heidi Zafra,2 John Anderson3 1Rocky Mountain Allergy, Tanner Clinic, Layton, UT, USA; 2Division of Allergy and Clinical Immunology, Medical College of Wisconsin, Milwaukee, WI, USA; 3AllerVie Health, Birmingham, AL, USACorrespondence ...
Jones D, Zafra H, Anderson J
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Contribution to the study of Myoferlin in Vesicle-Mediated Cancer Cellular Communication [PDF]
, 2016 Cellular communication is a fundamental phenomenon in all multicellular organisms. All cells in a human body must communicate with each other’s to govern biological functions, toensure all processes from the development of an egg, to the survival, and to the reproduction.
Fahmy, Karim
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