Results 31 to 40 of about 1,884 (173)

Myoferlin-Mediated Lysosomal Exocytosis Regulates Cytotoxicity by Phagocytes [PDF]

The Journal of Immunology, 2018
Abstract During inflammation, phagocytes release digestive enzymes from lysosomes to degrade harmful cells such as pathogens and tumor cells. However, the molecular mechanisms regulating this process are poorly understood. In this study, we identified myoferlin as a critical regulator of lysosomal exocytosis by mouse phagocytes ...
Yuji, Miyatake, Tomoyoshi, Yamano, Rikinari, Hanayama   +2 more
openaire   +2 more sources

Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression. [PDF]

PLoS ONE, 2012
Normal airway epithelial barrier function is maintained by cell-cell contacts which require the translocation of adhesion proteins at the cell surface, through membrane vesicle trafficking and fusion events.
Cleo Leung, Furquan Shaheen, Pascal Bernatchez, Tillie-Louise Hackett   +3 more
doaj   +1 more source

c-Met and EPHA7 Receptor Tyrosine Kinases Are Related to Prognosis in Clear Cell Renal Cell Carcinoma: Focusing on the Association with Myoferlin Expression. [PDF]

Cancers (Basel), 2022
Receptor tyrosine kinases (RTKs) are important targets for clear cell renal cell carcinoma (ccRCC) treatment. Myoferlin is a strong regulator of RTKs. To identify myoferlin-associated RTKs and their prognostic implications in ccRCC, we investigated the ...
Jung M, Lee S, Moon KC.
europepmc   +3 more sources

Myoferlin regulation by NFAT in muscle injury, regeneration and repair [PDF]

Journal of Cell Science, 2010
Ferlin proteins mediate membrane-fusion events in response to Ca2+. Myoferlin, a member of the ferlin family, is required for normal muscle development, during which it mediates myoblast fusion. We isolated both damaged and intact myofibers from a mouse model of muscular dystrophy using laser-capture microdissection and found that the levels of ...
Alexis R, Demonbreun, Karen A, Lapidos, Konstantina, Heretis, Samantha, Levin, Rodney, Dale, Peter, Pytel, Eric C, Svensson, Elizabeth M, McNally   +7 more
openaire   +2 more sources

The Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2 [PDF]

, 2013
Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death worldwide, with no satisfactory treatment to date. In this study, we tested whether the combined inhibition of cyclooxygenase-2 (COX-2) and class I histone deacetylase (HDAC ...
A Jemal, A Lehmann, A Turtoi, AH Rosendahl, Andrei Turtoi, Arnaud Gonzalez, BP Ashburner, C Detry, CF Deroanne, D Mottet, D Mottet, DA Richards, Denis Mottet, EI Deryugina, EL Deer, EV Broude, FJ Padillo, Guenter Schneider, H Ijichi, H Takahashi, H Zhang, H-J Kim, J Bai, J Daniluk, J Jones, JKL Colby, JS de Bono, K Miyake, KB Glaser, L Dumartin, L Ellis, L Gore, LF Chen, M Bots, M Donadelli, M Lieber, M Ouaïssi, M Ouaïssi, MA Molina, MD Reid, MH Tan, MJ Lee, N Tinari, O Khan, O Mehdi, Olivier Peulen, P Fritsche, P Mukherjee, P Peixoto, P Piacentini, Paul Peixoto, Philippe Delvenne, R Hill, R Pili, RA Schoumacher, S Iwahashi, S Iwahashi, S Jeong, S Wu, SF Zafar, SG Chun, T Kumagai, TD Penning, V Lamour, Vincent Castronovo, W Zhou, WH Allum, WH Sun, X Wang, Y Naito   +69 more
core   +5 more sources

Crystal structures of the human Dysferlin inner DysF domain [PDF]

, 2014
Background: Mutations in dysferlin, the first protein linked with the cell membrane repair mechanism, causes a group of muscular dystrophies called dysferlinopathies.
Cole, Ambrose R., Keep, Nicholas H., Orengo, C., Sula, Altin, Yeats, C.   +4 more
core   +1 more source

Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b [PDF]

, 2008
Mutations in the protein dysferlin, a member of the ferlin family, lead to limb girdle muscular dystrophy type 2B and Myoshi myopathy. The ferlins are large proteins characterised by multiple C2 domains and a single C-terminal membrane-spanning helix ...
Achanzar, Anderson, Aroul-Selvam, Bansal, Barker, Bashir, Bateman, Berg, Bernatchez, Bravo, Britton, Brunger, Cagliani, Cagliani, Cho, Cornilescu, Couet, Davis, de Luna, Delaglio, DeLano, Doherty, Dosset, Essen, Eugen-Matthias Strehle, Flocco, Glaser, Gouet, Han, Holm, Huang, James D. Watson, Katharine Bushby, Kawabe, Krissinel, Laskowski, Lennon, Letunic, Linge, Linge, Liu, Lu, Matsuda, Matsuda, McNeil, Miyoshi, Muhandiram, Nagashima, Nalefski, Nederveen, Nguyen, Nicholas H. Keep, Ottiger, Paul C. Driscoll, Ponting, Pryank Patel, Richard Harris, Rizo, Roux, Ruckert, Rumaisa Bashir, Somers, Stella M. Geddes, Sutton, Tagawa, Takahashi, Tan, Therrien, Vranken, Yamazaki, Yasunaga   +70 more
core   +1 more source

Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia

Journal of Extracellular Vesicles, Volume 12, Issue 12, December 2023., 2023
Abstract Periodontitis is a chronic inflammatory disease caused by periodontal pathogens in subgingival plaque and is associated with systemic inflammatory diseases. Extracellular vesicles (EVs) released from host cells and pathogens carry a variety of biological molecules and are of interest for their role in disease progression and as diagnostic ...
Younggap Lim, Hyun Young Kim, Dohyun Han, Bong‐Kyu Choi   +3 more
wiley   +1 more source

Annexin‐A5 and annexin‐A6 silencing prevents metastasis of breast cancer cells in zebrafish

Biology of the Cell, Volume 115, Issue 6, June 2023., 2023
Invasive and metastatic cancer cells are exposed to major mechanical constraints, which may induce plasma membrane damages. We show that highly invasive breast cancer cells survive to these mechanical stresses thanks to annexin‐A5 (ANXA5) and ANXA6, which are two major players of the membrane repair machinery.
Céline Gounou, Flora Bouvet, Benjamin Liet, Valérie Prouzet‐Mauléon, Léna d'Agata, Etienne Harté, Françoise Argoul, Géraldine Siegfried, Richard Iggo, Abdel‐Majid Khatib, Anthony Bouter   +10 more
wiley   +1 more source

Fer1L5, a Dysferlin Homologue Present in Vesicles and Involved in C2C12 Myoblast Fusion and Membrane Repair

Biology, 2020
Fer1L5 is a dysferlin and myoferlin related protein, which has been predicted to have a role in vesicle trafficking and muscle membrane fusion events. Mutations in dysferlin and otoferlin genes cause heredity diseases: muscular dystrophy and deafness in ...
R. Usha Kalyani, K. Perinbam, P. Jeyanthi, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Galal Ali Esmail, Young Ock Kim, Hyungsuk Kim, Hak-Jae Kim   +8 more
doaj   +1 more source