Results 31 to 40 of about 1,181 (166)

Loss of myoferlin redirects breast cancer cell motility towards collective migration.

PLoS ONE, 2014
Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal transition (EMT) and migrate as single cells.
Leonithas I Volakis, Ruth Li, William E Ackerman, Cosmin Mihai, Meagan Bechel, Taryn L Summerfield, Christopher S Ahn, Heather M Powell, Rachel Zielinski, Thomas J Rosol, Samir N Ghadiali, Douglas A Kniss   +11 more
doaj   +3 more sources

Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis [PDF]

Oncogenesis, 2023
Gilles Rademaker, Brunella Costanza, Justine Bellier, Michael Herfs, Raphaël Peiffer, Ferman Agirman, Naïma Maloujahmoum, Yvette Habraken, Philippe Delvenne, Akeila Bellahcène, Vincent Castronovo, Olivier Peulen   +11 more
doaj   +2 more sources

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies. [PDF]

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Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Frisby D, Misri G, Naslavsky N, Caplan S.   +3 more
europepmc   +2 more sources

Status quo and future developments in the diagnosis and treatment of hereditary angioedema. [PDF]

J Dtsch Dermatol Ges
Summary Hereditary angioedema (HAE) is a rare hereditary disease characterized by edema, which can be life‐threatening in case of swelling in the larynx. The most common form of HAE is caused by a mutation of the SERPING1 gene and is characterized by a deficiency (type I) or loss of function (type II) of the C1 inhibitor (C1‐INH), leading to excessive ...
Recke A.
europepmc   +2 more sources

Comprehensive Analysis of Myoferlin in Human Pancreatic Cancer via Bioinformatics [PDF]

BioMed Research International, 2021
Pancreatic cancer is the fourth leading cause of cancer‐related death and urgently needs biomarkers for clinical diagnosis and prognosis. It has been reported that myoferlin (MYOF) is implicated in the regulation of proliferation, invasion, and migration of tumor cells in many cancers including pancreatic cancer. To confirm the prognostic value of MYOF
Rou Pi, Yanmei Chen, Yijie Du, Suzhen Dong   +3 more
openaire   +2 more sources

Myoferlin, a Membrane Protein with Emerging Oncogenic Roles [PDF]

BioMed Research International, 2019
Myoferlin (MYOF), initially identified in muscle cells, is a member of the Ferlin family involved in membrane fusion, membrane repair, and membrane trafficking. Dysfunction of this protein is associated with muscular dysfunction. Recently, a growing body of studies have identified MYOF as an oncogenic protein.
Yimin Dong, Honglei Kang, Huiyong Liu, Jia Wang, Qian Guo, Chao Song, Yunlong Sun, Ya Zhang, Honghua Zhang, Zheng Zhang, Hanfeng Guan, Zhong Fang, Feng Li   +12 more
openaire   +3 more sources

Myoferlin is critical for endocytosis in endothelial cells [PDF]

American Journal of Physiology-Cell Physiology, 2009
Myoferlin is a member of the ferlin family of proteins that promotes endomembrane fusion with the plasma membrane in muscle cells and endothelial cells. In addition, myoferlin is necessary for the surface expression of vascular endothelial growth factor receptor 2 through the formation of a protein complex with dynamin-2 (Dyn-2).
Pascal N, Bernatchez, Arpeeta, Sharma, Pinar, Kodaman, William C, Sessa   +3 more
openaire   +2 more sources

Normal myoblast fusion requires myoferlin [PDF]

Development, 2005
Muscle growth occurs during embryonic development and continues in adult life as regeneration. During embryonic muscle growth and regeneration in mature muscle, singly nucleated myoblasts fuse to each other to form myotubes. In muscle growth, singly nucleated myoblasts can also fuse to existing large,syncytial myofibers as a mechanism of increasing ...
Katherine R, Doherty, Andrew, Cave, Dawn Belt, Davis, Anthony J, Delmonte, Avery, Posey, Judy U, Earley, Michele, Hadhazy, Elizabeth M, McNally   +7 more
openaire   +2 more sources

Loss of dysferlin or myoferlin results in differential defects in excitation–contraction coupling in mouse skeletal muscle

Scientific Reports, 2021
Muscular dystrophies are disorders characterized by progressive muscle loss and weakness that are both genotypically and phenotypically heterogenous. Progression of muscle disease arises from impaired regeneration, plasma membrane instability, defective ...
David Y. Barefield, Jordan J. Sell, Ibrahim Tahtah, Samuel D. Kearns, Elizabeth M. McNally, Alexis R. Demonbreun   +5 more
doaj   +1 more source

Myoferlin, a candidate gene and potential modifier of muscular dystrophy [PDF]

Human Molecular Genetics, 2000
Dysferlin, the gene product of the limb girdle muscular dystrophy (LGMD) 2B locus, encodes a membrane-associated protein with homology to Caenorhabditis elegans fer-1. Humans with mutations in dysferlin ( DYSF ) develop muscle weakness that affects both proximal and distal muscles.
D B, Davis, A J, Delmonte, C T, Ly, E M, McNally   +3 more
openaire   +2 more sources