Results 31 to 40 of about 1,180 (165)
Lysosomal Repair in Health and Disease [PDF]
Journal of Cellular Physiology, Volume 240, Issue 5, May 2025.Lysosomes are essential for cellular stress clearance and overall organismal health. Lysosomal membrane damage is tightly linked to various pathologies, including aging, neurodegeneration, lysosomal storage disorders, and cardiovascular disease.
Jinrui Xun, Jay Xiaojun Tan
wiley +2 more sources
Contribution to the study of Myoferlin in Vesicle-Mediated Cancer Cellular Communication [PDF]
, 2016 Cellular communication is a fundamental phenomenon in all multicellular organisms. All cells in a human body must communicate with each other’s to govern biological functions, toensure all processes from the development of an egg, to the survival, and to the reproduction.
Fahmy, Karim
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Loss of myoferlin redirects breast cancer cell motility towards collective migration.
PLoS ONE, 2014 Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal transition (EMT) and migrate as single cells.
Leonithas I Volakis +11 more
doaj +3 more sources
Managing Diagnosis, Treatment, and Burden of Disease in Hereditary Angioedema Patients with Normal C1-Esterase Inhibitor [PDF]
Journal of Asthma and Allergy, 2023 Douglas Jones,1 Heidi Zafra,2 John Anderson3 1Rocky Mountain Allergy, Tanner Clinic, Layton, UT, USA; 2Division of Allergy and Clinical Immunology, Medical College of Wisconsin, Milwaukee, WI, USA; 3AllerVie Health, Birmingham, AL, USACorrespondence ...
Jones D, Zafra H, Anderson J
doaj +2 more sources
Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis [PDF]
Oncogenesis, 2023 Gilles Rademaker +11 more
doaj +2 more sources
Comprehensive Analysis of Myoferlin in Human Pancreatic Cancer via Bioinformatics [PDF]
BioMed Research International, 2021 Pancreatic cancer is the fourth leading cause of cancer‐related death and urgently needs biomarkers for clinical diagnosis and prognosis. It has been reported that myoferlin (MYOF) is implicated in the regulation of proliferation, invasion, and migration of tumor cells in many cancers including pancreatic cancer. To confirm the prognostic value of MYOF
Rou Pi +3 more
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Myoferlin, a Membrane Protein with Emerging Oncogenic Roles [PDF]
BioMed Research International, 2019 Myoferlin (MYOF), initially identified in muscle cells, is a member of the Ferlin family involved in membrane fusion, membrane repair, and membrane trafficking. Dysfunction of this protein is associated with muscular dysfunction. Recently, a growing body of studies have identified MYOF as an oncogenic protein.
Yimin Dong +12 more
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Myoferlin is critical for endocytosis in endothelial cells [PDF]
American Journal of Physiology-Cell Physiology, 2009 Myoferlin is a member of the ferlin family of proteins that promotes endomembrane fusion with the plasma membrane in muscle cells and endothelial cells. In addition, myoferlin is necessary for the surface expression of vascular endothelial growth factor receptor 2 through the formation of a protein complex with dynamin-2 (Dyn-2).
Pascal N, Bernatchez +3 more
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Normal myoblast fusion requires myoferlin [PDF]
Development, 2005 Muscle growth occurs during embryonic development and continues in adult life as regeneration. During embryonic muscle growth and regeneration in mature muscle, singly nucleated myoblasts fuse to each other to form myotubes. In muscle growth, singly nucleated myoblasts can also fuse to existing large,syncytial myofibers as a mechanism of increasing ...
Katherine R, Doherty +7 more
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Myoferlin, a candidate gene and potential modifier of muscular dystrophy [PDF]
Human Molecular Genetics, 2000 Dysferlin, the gene product of the limb girdle muscular dystrophy (LGMD) 2B locus, encodes a membrane-associated protein with homology to Caenorhabditis elegans fer-1. Humans with mutations in dysferlin ( DYSF ) develop muscle weakness that affects both proximal and distal muscles.
D B, Davis +3 more
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