Results 41 to 50 of about 1,181 (166)

Myoferlin-Mediated Lysosomal Exocytosis Regulates Cytotoxicity by Phagocytes [PDF]

The Journal of Immunology, 2018
Abstract During inflammation, phagocytes release digestive enzymes from lysosomes to degrade harmful cells such as pathogens and tumor cells. However, the molecular mechanisms regulating this process are poorly understood. In this study, we identified myoferlin as a critical regulator of lysosomal exocytosis by mouse phagocytes ...
Yuji, Miyatake, Tomoyoshi, Yamano, Rikinari, Hanayama   +2 more
openaire   +2 more sources

Mechanistic modeling of the effects of myoferlin on tumor cell invasion [PDF]

Proceedings of the National Academy of Sciences, 2011
Myoferlin (MYOF) is a member of the evolutionarily conserved ferlin family of proteins, noted for their role in a variety of membrane processes, including endocytosis, repair, and vesicular transport. Notably, ferlins are implicated in Caenorhabditis elegans sperm motility (Fer-1), mammalian ...
Marisa C, Eisenberg, Yangjin, Kim, Ruth, Li, William E, Ackerman, Douglas A, Kniss, Avner, Friedman   +5 more
openaire   +2 more sources

Lysosomal Repair in Health and Disease. [PDF]

J Cell Physiol
Lysosomes are essential for cellular stress clearance and overall organismal health. Lysosomal membrane damage is tightly linked to various pathologies, including aging, neurodegeneration, lysosomal storage disorders, and cardiovascular disease.
Xun J, Tan JX.
europepmc   +2 more sources

Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin. [PDF]

Adv Biol (Weinh), 2023
AbstractTetraspanins organize protein complexes at the cell membrane and are responsible for assembling diverse binding partners in changing cellular states. Tetraspanin CD82 is a useful cell surface marker for prospective isolation of human myogenic progenitors and its expression is decreased in Duchenne muscular dystrophy (DMD) cell lines.
Fontelonga T, Hall AJ, Brown JL, Jung YL, Alexander MS, Dominov JA, Mouly V, Vieira N, Zatz M, Vainzof M, Gussoni E.   +10 more
europepmc   +3 more sources

Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b [PDF]

, 2008
Mutations in the protein dysferlin, a member of the ferlin family, lead to limb girdle muscular dystrophy type 2B and Myoshi myopathy. The ferlins are large proteins characterised by multiple C2 domains and a single C-terminal membrane-spanning helix ...
Geddes, Stella M., Keep, Nicholas H., Bashir, R., Driscoll, P.C., Patel, P., Harris, R., Bushby, K., Watson, J.D., Strehle, E.M.   +8 more
core   +1 more source

Fer1L5, a Dysferlin Homologue Present in Vesicles and Involved in C2C12 Myoblast Fusion and Membrane Repair

Biology, 2020
Fer1L5 is a dysferlin and myoferlin related protein, which has been predicted to have a role in vesicle trafficking and muscle membrane fusion events. Mutations in dysferlin and otoferlin genes cause heredity diseases: muscular dystrophy and deafness in ...
R. Usha Kalyani, K. Perinbam, P. Jeyanthi, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Galal Ali Esmail, Young Ock Kim, Hyungsuk Kim, Hak-Jae Kim   +8 more
doaj   +1 more source

Co-localization of myoferlin and ZO-1. [PDF]

, 2012
16HBE cells were grown on 8 well chamber slides and treated with (A) transfection control, (B) scrambled siRNA, or (C) myoferlin siRNA both at 75 nM concentration for 72 h then fixed for immunofluorescence analysis.
Tillie-Louise Hackett (92016), Furquan Shaheen (152799), Pascal Bernatchez (152801), Cleo Leung (152795)   +3 more
core   +1 more source

Knockdown of Myoferlin Suppresses Migration and Invasion in Clear-Cell Renal-Cell Carcinoma [PDF]

Anticancer Research, 2020
Myoferlin (MYOF) has emerged as an oncogenic protein in various human cancer types. This study was conducted to investigate comprehensively the expression and functional properties of MYOF in clear-cell renal-cell carcinoma (ccRCC) with respect to its value as diagnostic biomarker and therapeutic target.mRNA and protein expression of MYOF were assessed
ALEXANDER COX, CHENMING ZHAO, YURI TOLKACH, DANIEL NETTERSHEIM, DORIS SCHMIDT, GLEN KRISTIANSEN, STEFAN C. MUELLER, MANUEL RITTER, STEFAN HAUSER, JOERG ELLINGER   +9 more
openaire   +2 more sources

Functions of Vertebrate Ferlins

Cells, 2020
Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six ferlin genes encoding, in humans, dysferlin, otoferlin, myoferlin, Fer1L5 and 6
Anna V. Bulankina, Sven Thoms
doaj   +1 more source

An Emerging Therapeutic Approach by Targeting Myoferlin (MYOF) for Malignant Tumors

Current Topics in Medicinal Chemistry, 2020
:Myoferlin (MYOF), as a member of the ferlin family, is a type II transmembrane protein with a single transmembrane domain at the carbon terminus. Studies have shown that MYOF is involved in pivotal physiological functions related to numerous cell membranes, such as extracellular secretion, endocytosis cycle, vesicle trafficking, membrane repair ...
Haijun, Gu, Yangrui, Peng, Yihua, Chen
openaire   +2 more sources