Results 41 to 50 of about 1,884 (173)

LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation [PDF]

, 2012
Carefully orchestrated intercellular communication is an essential prerequisite for the development of multicellular organisms. In recent years, tunneling nanotubes (TNT) have emerged as a novel and widespread mechanism of cell-cell communication ...
Diakopoulos, Kalliope N., Kremmer, Elisabeth, Ohno, Hiroshi, Rohwedder, Ina, Schiller, Christian, Toerne, Christine von, Ueffing, Marius, Weidle, Ulrich H., Weiss, Elisabeth H.   +8 more
core   +2 more sources

Fluorescent Flippers: Small‐Molecule Probes to Image Membrane Tension in Living Systems

Angewandte Chemie, Volume 135, Issue 20, May 8, 2023., 2023
The emergence of fluorescent flippers as membrane tension probes is described in the context of the general challenge to create chemistry tools to image physical forces in living systems. Abstract Flipper probes have been introduced as small molecule fluorophores to image physical forces, that is, membrane tension in living systems.
Xiao‐Xiao Chen, Felix Bayard, Nerea Gonzalez‐Sanchis, Khurnia Krisna Puji Pamungkas, Naomi Sakai, Stefan Matile   +5 more
wiley   +1 more source

The Dysferlin Domain-Only Protein, Spo73, Is Required for Prospore Membrane Extension in Saccharomyces cerevisiae [PDF]

, 2016
Sporulation of Saccharomyces cerevisiae is a developmental process in which an ascus containing four haploid spores forms from a diploid cell. During this process, newly formed membrane structures called prospore membranes extend along the nuclear ...
Gao Xiao-Dong, Inoue Ichiro, Nakamura Shugo, Nakamura Tsuyoshi S., Nakanishi Hideki, Okumura Yuuya, Suda Yasuyuki, Tachikawa Hiroyuki, Takahashi Tetsuo, Tanaka Takayuki, 須田 恭之   +10 more
core   +1 more source

Functions of Vertebrate Ferlins

Cells, 2020
Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six ferlin genes encoding, in humans, dysferlin, otoferlin, myoferlin, Fer1L5 and 6
Anna V. Bulankina, Sven Thoms
doaj   +1 more source

A Novel Homozygous Abnormal Splice Variant in the Myoferlin Gene Leading to Floppy Infant Syndrome in a Saudi Family

Journal of Disability Research, 2023
Myoferlin (MYOF) (OMIM#604603) is a type II membrane protein that belongs to the ferlin family, which is expressed in cardiac and skeletal muscles. This protein has seven C2 domains that mediate calcium-dependent membrane fusion events and membrane ...
Angham Abdulrahman Abdulkareem, Bader H. Shirah, Osama Yousef Muthaffar, Hala Abubaker Bagabir, Muhammad Imran Naseer   +4 more
doaj   +1 more source

The muscle protein dysferlin accumulates in the Alzheimer brain [PDF]

, 2006
Dysferlin is a transmembrane protein that is highly expressed in muscle. Dysferlin mutations cause limb-girdle dystrophy type 2B, Miyoshi myopathy and distal anterior compartment myopathy. Dysferlin has also been described in neural tissue.
James E. Galvin, Divya Palamand, Jeff Strider, Margherita Milone, Alan Pestronk, M Aoki, V Askanas, D Bansal, D Bansal, R Bashir, S Britton, B Caughey, G Cenacchi, DB Davis, B Dermaut, KR Doherty, JE Galvin, JE Galvin, JE Galvin, JE Galvin, JE Galvin, M Goedert, YK Hayashi, M Ho, M Ho, EP Hoffman, PJ Holzfeind, I Illa, Y Ling, G McKhann, JC Morris, S Salani, MC Sharma, MG Spillantini, S Yasunaga   +34 more
core   +1 more source

Dysferlin and Myoferlin Regulate Transverse Tubule Formation and Glycerol Sensitivity

The American Journal of Pathology, 2014
Dysferlin is a membrane-associated protein implicated in muscular dystrophy and vesicle movement and function in muscles. The precise role of dysferlin has been debated, partly because of the mild phenotype in dysferlin-null mice (Dysf). We bred Dysf mice to mice lacking myoferlin (MKO) to generate mice lacking both myoferlin and dysferlin (FER).
Demonbreun, Alexis R., Rossi, Ann E., Alvarez, Manuel G., Swanson, Kaitlin E., Deveaux, H. Kieran, Earley, Judy U., Hadhazy, Michele, Vohra, Ravneet, Walter, Glenn A., Pytel, Peter, McNally, Elizabeth M.   +10 more
openaire   +2 more sources

Ferlin Overview: From Membrane to Cancer Biology

Cells, 2019
In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids.
Olivier Peulen, Gilles Rademaker, Sandy Anania, Andrei Turtoi, Akeila Bellahcène, Vincent Castronovo   +5 more
doaj   +1 more source

Mechanistic modeling of the effects of myoferlin on tumor cell invasion [PDF]

Proceedings of the National Academy of Sciences, 2011
Myoferlin (MYOF) is a member of the evolutionarily conserved ferlin family of proteins, noted for their role in a variety of membrane processes, including endocytosis, repair, and vesicular transport. Notably, ferlins are implicated in Caenorhabditis elegans sperm motility (Fer-1), mammalian skeletal muscle ...
Marisa C, Eisenberg, Yangjin, Kim, Ruth, Li, William E, Ackerman, Douglas A, Kniss, Avner, Friedman   +5 more
openaire   +2 more sources

Lack of correlation between outcomes of membrane repair assay and correction of dystrophic changes in experimental therapeutic strategy in dysferlinopathy.

PLoS ONE, 2012
Mutations in the dysferlin gene are the cause of Limb-girdle Muscular Dystrophy type 2B and Miyoshi Myopathy. The dysferlin protein has been implicated in sarcolemmal resealing, leading to the idea that the pathophysiology of dysferlin deficiencies is ...
William Lostal, Marc Bartoli, Carinne Roudaut, Nathalie Bourg, Martin Krahn, Marina Pryadkina, Perrine Borel, Laurence Suel, Joseph A Roche, Daniel Stockholm, Robert J Bloch, Nicolas Levy, Rumaisa Bashir, Isabelle Richard   +13 more
doaj   +1 more source