Results 61 to 70 of about 1,180 (165)
The multifactorial impact of receiving a hereditary angioedema diagnosis
World Allergy Organization Journal, 2023 Hereditary angioedema (HAE) is a rare, chronic, debilitating genetic disorder characterized by recurrent, unpredictable, and potentially life-threatening episodes of swelling that typically affect the extremities, face, abdomen, genitals, and larynx. The Jason Raasch, MD, Mark C Glaum, MD, PhD, Maeve O’Connor, MD +2 moredoaj +1 more sourceCo-localization of myoferlin and ZO-1.
, 2012 16HBE cells were grown on 8 well chamber slides and treated with (A) transfection control, (B) scrambled siRNA, or (C) myoferlin siRNA both at 75 nM concentration for 72 h then fixed for immunofluorescence analysis.Tillie-Louise Hackett (92016), Furquan Shaheen (152799), Pascal Bernatchez (152801), Cleo Leung (152795) +3 morecore +1 more sourceSurface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells. [PDF]
PLoS Neglected Tropical Diseases, 2019 Helminth parasites secrete extracellular vesicles (EVs) that can be internalised by host immune cells resulting in modulation of host immunity. While the molecular cargo of EVs have been characterised in many parasites, little is known about the surface ...Eduardo de la Torre-Escudero, Jared Q Gerlach, Adam P S Bennett, Krystyna Cwiklinski, Heather L Jewhurst, Kathryn M Huson, Lokesh Joshi, Michelle Kilcoyne, Sandra O'Neill, John P Dalton, Mark W Robinson +10 moredoaj +1 more sourceThe International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria
Allergy, EarlyView.ABSTRACT
This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...T. Zuberbier, Z. Abdul Hameed Ansari, A. H. Abdul Latiff, M. M. Abuzakouk, M. S. Agcaoili‐De Jesus, R. C. Agondi, M. Al‐Ahmad, A. A. Alangari, H. Alhameli, C. D. Alonso Bello, S. Alshareef, S. Al‐Tamemi, S. Altrichter, H. Al Wahshi, S. Aquilina, M. Araújo, R. Arnaout, R. Asero, B. Ballmer‐Weber, C. Bangert, A. Bauer, M. Ben‐Shoshan, J. A. Bernstein, C. Bindslev‐Jensen, M. Bizjak, I. Boccon‐Gibod, H. Bonnekoh, L. Bouillet, K. Brockow, Z. Brzoza, M. Bulatović Ćalasan, A. Bulkhi, T. Buttgereit, A. Bygum, T. Caballero, O. Calderon, R. Campos, M. Cancian, E. Carne, M. A. Castor, I. Cerecedo, T. Çetinarslan, I. Cherrez‐Ojeda, N. Chkhikvadze, H. J. Chong‐Neto, K. Choo, G. Christoff, C.‐Y. Chu, K. Ciupka, N. Conlon, C. Costa, T. Craig, P. Criado, I. Danilycheva, R. Darlenski, E. De Arruda Chaves, L. de Montjoye, M. S. Doutre, A. Du‐Thanh, D. Ebo, S. Elkhalifa, S. Elmariah, T. El‐Shanawany, L. F. Ensina, R. Ertaş, R. Fachini Jardim Criado, M. Ferrer, S. Ferrucci, J. S. Fok, D. Fomina, L. Fonacier, G. Fouda, I. Francescantonio, A. Fukunaga, C. A. Galvan Calle, E. Garcia, K. Gáspár, A. Gelincik, S. Geng, K. Godse, M. Gonçalo, M. Gotua, C. Grattan, M. Grosber, G. Guidos Fogelbach, M. Guilarte, R. Guillod, E. Hamelmann, J. Hawkes, K. Hayama, R. Heuer, M. Hide, W. Hoetzenecker, N. Inomata, H.‐R. Kang, A. Kaplan, A. Kapp, M. Karam, A. Kasperska‐Zajac, C. H. Katelaris, A. Kessel, M. Khoshkhui, B. Kim, T. Kinaciyan, E. Kocatürk, M. Kolacinska‐Flont, P. Kolkhir, G. N. Konstantinou, M. Kosnik, D. Krasowska, K. Kulthanan, M. S. Kumaran, I. Kuprys‐Lipinska, M. Labrador, J. I. Larco, D. Larenas‐Linnemann, E. Latysheva, E. Lazaridou, P. H. Li, H. Lima, U. Lippert, M. Magerl, M. Makris, J. Alves Marcelino, A. V. Marzano, I. Medina, R. Meshkova, D. Micallef, R. Mohammed Ali, C. G. Mortz, M. Munoz, H. N. G. Oude Elberink, A. Nakonechna, I. Nasr, A. Nast, E. Netchiporouk, E. Nettis, S. Nieto, I. Ogueta Canales, T.‐L. Okas, R. L. Orfali, E. Özkaya, C. Parisi, A. Pennitz, R. Pawankar, M. P. Pereira, J. Peter, E. Petkova, P. D. Pigatto, I. Podder, T. Popov, G. Porebski, P. Pyatilova, G. D. Ramon, H. A. Ratti Sisa, M. Recto, K. Ress, K. Ridge, M. Riedl, C. Ritchie, N. Rosario Filho, I. Rosmaninho, M. Rudenko, M. Rukhadze, K. Rutkowski, V. Sabato, U. M. Sahiner, S. Saini, F. Saleh Al Sabbagh, A. Salman, F. Salvo, J. Sanchez, A. Santucci, S. Schliemann, P. Schmid‐Grendelmeier, B. E. Sekerel, F. Serpa, F. Sheikh, J. Sheikh, H. Shendi, F. Siebenhaar, M. Sonomjamts, A. Soria, B. Sousa Pinto, M. Staevska, P. Staubach, M. Stephan, K. Stevanovic, L. Stingeni, M. Stobiecki, Ö. Su Küçük, G. Sussman, A. Szegedi, S. Takahagi, A. Tanaka, N. Teovska Mitrevska, S. F. Thomsen, E. Toubi, F. Tsatsou, M. Turk, Z. Vadasz, A. Valerieva, S. Valle, M. v. Doorn, B. Veleiro Perez, C. E. Vera Ayala, C. Vestergaard, R. J. Vieira, C. W. Maruta, B. Wedi, R. N. Werner, E. W. Y. Yap, P. Xepapadaki, Y. Xiang, Y.‐M. Ye, P. Yong, G. Yosipovitch, A. Z. J. Zalewska‐Janowska, C. Zeyen, Z. Zhao, M. Metz, A. M. Giménez‐Arnau +221 morewiley +1 more sourceCharacterization of the Myoferlin transgenic mice. A
, 2012 /Schematic representation of the Myof construct and Hprt targeted allele. B/Quantitative RT-PCR for myoferlin expression in muscles of WT and TgMyof revealed a 200-fold greater expression in the transgenic.Carinne Roudaut (162223), William Lostal (162211), Laurence Suel (162256), Daniel Stockholm (25425), Martin Krahn (162235), Rumaisa Bashir (162275), Marina Pryadkina (162240), Nicolas Levy (1708774), Marc Bartoli (162219), Robert J. Bloch (162268), Isabelle Richard (162281), Perrine Borel (162248), Joseph A. Roche (162262), Nathalie Bourg (162229) +13 morecore +1 more sourceA small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
Nature Communications, 2018 Improved therapeutics are needed for treating breast cancer. Here they show the druggability of myoferlin with a small molecule inhibitor in breast cancer and demonstrate its anti-breast cancer effects in vitro and in vivo.Tao Zhang, Jingjie Li, Yuan He, Feifei Yang, Yun Hao, Wangrui Jin, Jing Wu, Zhenliang Sun, Yunqi Li, Yihua Chen, Zhengfang Yi, Mingyao Liu +11 moredoaj +1 more sourceGaradacimab for the long‐term prophylaxis of hereditary angioedema
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary
Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl +5 morewiley +1 more sourceMyoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer
, 2016 peer reviewedMyoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells.De Pauw, Edwin, Turtoi, Andrei, Le Goff, Caroline, Cavalier, E, Castronovo, V., Hirano, T, Goldman, S, Lifrange, E, Blomme, Adrien, Cusumano, P G, Doumont, G, Di Valentin, Emmanuel, Costanza, Brunella, Bellahcene, Akeila, Di Valentin, E, Muller, RN, Yokobori, T, Delvenne, P, Le Goff, Carine, Van Simaeys, Gaëtan, Boutry, S, De Tullio, Pascal, Costanza, B, Boutry, Sébastien, Doumont, Gilles, Blomme, Arnaud, Delvenne, Philippe, Sherer, F, Mouithys-Mickalad, Ange, Cavalier, Etienne, LIFRANGE, Eric, Goldman, Serge, Peulen, Olivier, Sherer, Félicie, Jouret, François, Thiry, M., Thiry, Marc, Castronovo, Vincenzo, GOFFLOT, Stéphanie, Muller, Robert N, De Pauw, E, Van Simaeys, G, Nishiyama, M, CUSUMANO, Giuseppe +43 morecore +2 more sources
