Results 61 to 70 of about 1,281 (134)

Analysis of disease burden in patients with hereditary angioedema from Japan by patient‐reported outcomes

The Journal of Dermatology, Volume 52, Issue 2, Page 256-269, February 2025.
Abstract Hereditary angioedema (HAE) symptoms can vary greatly. Disease burden evaluation is essential for providing adequate treatments for patients. Patient‐reported outcome measures (PROMs), including the 12‐Item Short Form Health Survey (SF‐12), the Angioedema Quality of Life (AE‐QoL), the Hospital Anxiety and Depression Scale (HADS), and the Work ...
Michihiro Hide, Miwa Kishimoto, Ippei Kotera, Akinori Oh, Yoichi Inoue, Beverley Anne Yamamoto, Shinichi Noto   +6 more
wiley   +1 more source

Mechanistic Insights Into GDFMD‐Mediated Inhibition of Liver Fibrosis via miRNA‐29b‐3p Upregulation in Wilson’s Disease

Mediators of Inflammation, Volume 2025, Issue 1, 2025.
Background: Wilson’s disease (WD) is an abnormal copper metabolism disease. GanDouFuMu decoction (GDFMD) is a traditional Chinese medicine, whicn has shown good therapeutic effects in clinical treatment of WD liver fibrosis;but its regulatory mechanism is still unclear.
Peng Huang, Yuzhe Huang, Ting Dong, Han Wang, Meixia Wang, Xiang Li, Wei Dong, Yulong Yang, Wei He, Wenming Yang, Palash Mandal   +10 more
wiley   +1 more source

Algorithms in Allergy: Hereditary Angioedema

Allergy, Volume 81, Issue 8, Page 3008-3012, August 2026.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

Size matters: Biomolecular compositions of small and large extracellular vesicles in the urine of glioblastoma patients

Journal of Extracellular Biology, Volume 3, Issue 11, November 2024.
Abstract The promise of urinary extracellular vesicles (uEVs) in biomarker discovery is emerging. However, the characteristics and compositions of different uEV subpopulations across normal physiological and pathological states require rigorous explication.
Susannah M. Hallal, Liam A. Sida, Ágota Tűzesi, Brindha Shivalingam, Hao‐Wen Sim, Michael E. Buckland, Laveniya Satgunaseelan, Kimberley L. Alexander   +7 more
wiley   +1 more source

Localization of dysferlin and myoferlin in airway epithelial cells.

, 2012
16HBE cells were grown to confluency on 8 well chamber slides and fixed for immunofluorescence analysis. Immunofluorescent staining for (A) dysferlin (red), (B) myoferlin (red), (C) mouse immunoglobulin isotype, and nuclei stained with 4′,6-diamidino-2 ...
Tillie-Louise Hackett (92016), Furquan Shaheen (152799), Pascal Bernatchez (152801), Cleo Leung (152795)   +3 more
core   +1 more source

Myoferlin: an indispensable component in VEGFA secretion by pancreas cancer cells [PDF]

, 2015
In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in pancreas cancer cells, BxPC-3, provoques a decrease in ...
Turtoi, Andrei, Castronovo, Vincenzo, Thiry, Marc, PEIXOTO, Paul, Delvenne, Philippe, ARAFA, Mohamed, Gonzalez, Arnaud, Fahmy, Karim, Peulen, Olivier, Bellahcene, Akeila   +9 more
core   +1 more source

Myoferlin controls mitochondrial structure in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the third leading cause of cancer related death. Therapeutic options remain very limited and are still based on classical chemotherapies.
Durieux, Florence, Delvenne, Philippe, Costanza, Brunella, Bettendorff, Lucien, Bellahcene, Akeila, Peulen, Olivier, Hennequière, Vincent, LOVINFOSSE, Pierre, Castronovo, Vincenzo, Peiffer, Raphaël, Hustinx, Roland, Nokin, Marie-Julie, Herfs, Michael, GOFFLOT, Stéphanie, Brohée, Laura, Bellier, Justine, Deroanne, Christophe, Rademaker, Gilles   +17 more
core   +1 more source

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

Medicinal Research Reviews, Volume 44, Issue 6, Page 2472-2509, November 2024.
Abstract Previously, lysosomes were primarily referred to as the digestive organelles and recycling centers within cells. Recent discoveries have expanded the lysosomal functional scope and revealed their critical roles in nutrient sensing, epigenetic regulation, plasma membrane repair, lipid transport, ion homeostasis, and cellular stress response ...
Yuchen He, Yishu Fan, Xenab Ahmadpoor, Yumin Wang, Zhong Alan Li, Weihong Zhu, Hang Lin   +6 more
wiley   +1 more source

Targeting factor XIIa for therapeutic interference with hereditary angioedema

Journal of Internal Medicine, Volume 296, Issue 4, Page 311-326, October 2024.
Abstract Hereditary angioedema (HAE) is a rare, potentially life‐threatening genetic disorder characterized by recurrent attacks of swelling. Local vasodilation and vascular leakage are stimulated by the vasoactive peptide bradykinin, which is excessively produced due to dysregulation of the activated factor XII (FXIIa)‐driven kallikrein–kinin system ...
Danny M. Cohn, Thomas Renné
wiley   +1 more source

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Hypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on cellular metabolism. As such, hypoxia is an important contributor to cancer progression and is associated with a poor prognosis.
Joël E. J. Beaumont, Lydie M. O. Barbeau, Jinzhe Ju, Kim G. Savelkouls, Freek G. Bouwman, Marijke I. Zonneveld, Annelies Bronckaers, Kim R. Kampen, Tom G. H. Keulers, Kasper M. A. Rouschop   +9 more
wiley   +1 more source