Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells. [PDF]
PLoS Neglected Tropical Diseases, 2019 Helminth parasites secrete extracellular vesicles (EVs) that can be internalised by host immune cells resulting in modulation of host immunity. While the molecular cargo of EVs have been characterised in many parasites, little is known about the surface ...
Eduardo de la Torre-Escudero +10 more
doaj +1 more source
No effect of dysferlin or myoferlin knockdown on VEGFR-2 and caveolin-1 expression. [PDF]
, 2012 16HBE cells were transfected with oligofectamine transfection reagent (TF con), scrambled siRNA (S), dysferlin or myoferlin siRNA at 50 nM, 75 nM and 100 nM for 72 h.
Tillie-Louise Hackett (92016) +3 more
core +1 more source
Garadacimab for the long‐term prophylaxis of hereditary angioedema
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün +5 more
wiley +1 more source
Myoferlin, a new autophagy player in pancreatic cancer cells [PDF]
, 2017 Despite intensive research, Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the deadliest forms of cancer. Early-stage of the disease is clinically silent and the diagnosis of the disease is mostly made at an advanced stage.
Hennequière, Vincent +5 more
core
A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
Nature Communications, 2018 Improved therapeutics are needed for treating breast cancer. Here they show the druggability of myoferlin with a small molecule inhibitor in breast cancer and demonstrate its anti-breast cancer effects in vitro and in vivo.
Tao Zhang +11 more
doaj +1 more source
Myoferlin is required for insulin‐like growth factor response and muscle growth
The FASEB Journal, 2009 ABSTRACT Insulin‐like growth factor (IGF) is a potent stimulus of muscle growth. Myoferlin is a membraneassociated protein important for muscle development and regeneration. Myoferlin‐null mice have smaller muscles and defective myoblast fusion.
Alexis R, Demonbreun +6 more
openaire +3 more sources
Acta Physiologica, Volume 242, Issue 8, August 2026.ABSTRACT Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to account for anatomical variation, and may not accurately recapitulate progressive PAD pathophysiology ...
Oliver Kitzerow +4 more
wiley +1 more source
Treatment of Hereditary Angioedema With Plasma‐Derived C1 Inhibitor: A Review
Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.ABSTRACT Hereditary angioedema (HAE) is clinically characterized by recurrent episodes of localized edema. HAE typically occurs due to a deficiency of functional C1 inhibitor (C1INH, HAE‐C1INH); in addition, several types of HAE with normal quantity and activity of C1INH (HAE‐nC1INH) have recently been classified, which occur due to different gene ...
Inmaculada Martinez‐Saguer +3 more
wiley +1 more source
Knockdown of myoferlin but not dysferlin alters cell morphology and cell detachment. [PDF]
, 2012 Phase contrast images captured at 10× magnification of 16HBE cells treated with control media, transfection control, scrambled siRNA, and (A) dysferlin siRNA or (B) myoferlin siRNA at 50 nM, 75 nM and 100 nM for 72 h.
Tillie-Louise Hackett (92016) +3 more
core +1 more source
Table_2_Identification of Myoferlin, a Potential Serodiagnostic Antigen of Clonorchiasis, via Immunoproteomic Analysis of Sera From Different Infection Periods and Excretory-Secretory Products of Clonorchis sinensis.docx [PDF]
, 2021 Clonorchiasis, which is caused by Clonorchis sinensis, is an important foodborne disease worldwide. The excretory-secretory products (ESPs) of C. sinensis play important roles in host-parasite interactions by acting as causative agents.
Yang-Yuan Qiu (11574760) +7 more
core +1 more source