Results 71 to 80 of about 1,180 (165)

Treatment of Hereditary Angioedema With Plasma‐Derived C1 Inhibitor: A Review

Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.
ABSTRACT Hereditary angioedema (HAE) is clinically characterized by recurrent episodes of localized edema. HAE typically occurs due to a deficiency of functional C1 inhibitor (C1INH, HAE‐C1INH); in addition, several types of HAE with normal quantity and activity of C1INH (HAE‐nC1INH) have recently been classified, which occur due to different gene ...
Inmaculada Martinez‐Saguer, Ingo Pragst, Beverley Worrall, Konrad Bork   +3 more
wiley   +1 more source

Myoferlin is required for insulin‐like growth factor response and muscle growth

The FASEB Journal, 2009
ABSTRACT Insulin‐like growth factor (IGF) is a potent stimulus of muscle growth. Myoferlin is a membraneassociated protein important for muscle development and regeneration. Myoferlin‐null mice have smaller muscles and defective myoblast fusion.
Alexis R, Demonbreun, Avery D, Posey, Konstantina, Heretis, Kayleigh A, Swaggart, Judy U, Earley, Peter, Pytel, Elizabeth M, McNally   +6 more
openaire   +3 more sources

C1 inhibitor deficient hereditary angioedema is related to endothelial dysfunction in young adult and middle‐aged patients

Clinical and Translational Allergy, Volume 15, Issue 6, June 2025.
Abstract Background Hereditary angioedema (HAE) is a rare, autosomal dominantly inherited disease characterised by mucocutaneous oedema attacks. Vasoactive mediators and the endothelium play an important role in the pathogenesis of HAE. We aimed to evaluate the endothelial dysfunction in HAE. Methods The study included 35 C1 inhibitor deficient (C1‐INH)
Gokce Gul Atay Sensoy, Derya Baykız, İlkim Deniz Toprak, Deniz Eyice Karabacak, Erdem Bektas, Derya Unal, Aslı Gelincik, Semra Demir   +7 more
wiley   +1 more source

Analysis of disease burden in patients with hereditary angioedema from Japan by patient‐reported outcomes

The Journal of Dermatology, Volume 52, Issue 2, Page 256-269, February 2025.
Abstract Hereditary angioedema (HAE) symptoms can vary greatly. Disease burden evaluation is essential for providing adequate treatments for patients. Patient‐reported outcome measures (PROMs), including the 12‐Item Short Form Health Survey (SF‐12), the Angioedema Quality of Life (AE‐QoL), the Hospital Anxiety and Depression Scale (HADS), and the Work ...
Michihiro Hide, Miwa Kishimoto, Ippei Kotera, Akinori Oh, Yoichi Inoue, Beverley Anne Yamamoto, Shinichi Noto   +6 more
wiley   +1 more source

Mechanistic Insights Into GDFMD‐Mediated Inhibition of Liver Fibrosis via miRNA‐29b‐3p Upregulation in Wilson’s Disease

Mediators of Inflammation, Volume 2025, Issue 1, 2025.
Background: Wilson’s disease (WD) is an abnormal copper metabolism disease. GanDouFuMu decoction (GDFMD) is a traditional Chinese medicine, whicn has shown good therapeutic effects in clinical treatment of WD liver fibrosis;but its regulatory mechanism is still unclear.
Peng Huang, Yuzhe Huang, Ting Dong, Han Wang, Meixia Wang, Xiang Li, Wei Dong, Yulong Yang, Wei He, Wenming Yang, Palash Mandal   +10 more
wiley   +1 more source

Localization of dysferlin and myoferlin in airway epithelial cells.

, 2012
16HBE cells were grown to confluency on 8 well chamber slides and fixed for immunofluorescence analysis. Immunofluorescent staining for (A) dysferlin (red), (B) myoferlin (red), (C) mouse immunoglobulin isotype, and nuclei stained with 4′,6-diamidino-2 ...
Tillie-Louise Hackett (92016), Furquan Shaheen (152799), Pascal Bernatchez (152801), Cleo Leung (152795)   +3 more
core   +1 more source

Quantitative Proteome Reveals Variation in the Condition Factor of Sea Urchin Strongylocentrotus nudus during the Fishing Season Using an iTRAQ-based Approach

Marine Drugs, 2019
To investigate the variation in the condition factor of the sea urchin Strongylocentrotus nudus (S. nudus), gonads were collected in May (MAY), June (JUN), and July (JUL), at the beginning (AUG-b) and end of August (AUG-e).
Wen-Hui Shang, Jia-Run Han, Jia-Nan Yan, Yi-Nan Du, Yun-Sheng Xu, Chang-Feng Xue, Tie-Tao Zhang, Hai-Tao Wu, Bei-Wei Zhu   +8 more
doaj   +1 more source

Size matters: Biomolecular compositions of small and large extracellular vesicles in the urine of glioblastoma patients

Journal of Extracellular Biology, Volume 3, Issue 11, November 2024.
Abstract The promise of urinary extracellular vesicles (uEVs) in biomarker discovery is emerging. However, the characteristics and compositions of different uEV subpopulations across normal physiological and pathological states require rigorous explication.
Susannah M. Hallal, Liam A. Sida, Ágota Tűzesi, Brindha Shivalingam, Hao‐Wen Sim, Michael E. Buckland, Laveniya Satgunaseelan, Kimberley L. Alexander   +7 more
wiley   +1 more source

Morphology change following myoferlin depletion in MDA-MB-231 cells.

, 2012
Immunofluorescence micrographs showing the morphology of MDA-MB-231 wild type (WT), lentiviral transduction control (LTV-ctrl), and myoferlin knockdown (MYOF-KD) stable cell lines in culture.
Samir Ghadiali (155520), Douglas A. Kniss (155523), William E. Ackerman IV (155503), Leonithas I. Volakis (155515), Ruth Li (155497), Cosmin Mihai (155508)   +5 more
core   +2 more sources

Myoferlin: an indispensable component in VEGFA secretion by pancreas cancer cells. [PDF]

, 2015
In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in pancreas cancer cells, BxPC-3, provoques a decrease in ...
Fahmy, Karim
core