Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR [PDF]
, 2017 Metastasis is respoMetastasis is responsible for most cancer-related deaths, and, among common tumor types, melanoma is one with great potential to metastasize.
Berrocal, Alfonso +29 more
core +1 more source
Calpain cleavage and subcellular characterisation of the ferlin family. [PDF]
, 2016 The ferlins are a family of C2-domain containing proteins. C2 domains regulate vesicle fusion in synaptotagmins, and animal models of ferlin deficiency display pathologies related to Ca2+-dependent vesicle fusion.
Redpath, Gregory
core +2 more sources
Garadacimab for the long‐term prophylaxis of hereditary angioedema
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün +5 more
wiley +1 more source
Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis [PDF]
, 2009 BACKGROUND: Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, a Gram-negative bacillus classified by the National Institute of Allergy and Infectious Diseases (NIAID) as a category B priority agent.
Banchereau, Jacques +7 more
core +3 more sources
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure [PDF]
, 2023 Invasive bacteria enter the cytosol of host cells through initial uptake into bacteria‐containing vacuoles (BCVs) and subsequent rupture of the BCV membrane, thereby exposing to the cytosol intraluminal, otherwise shielded danger signals such as glycans ...
Boyle, Keith B +9 more
core +2 more sources
Treatment of Hereditary Angioedema With Plasma‐Derived C1 Inhibitor: A Review
Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.ABSTRACT Hereditary angioedema (HAE) is clinically characterized by recurrent episodes of localized edema. HAE typically occurs due to a deficiency of functional C1 inhibitor (C1INH, HAE‐C1INH); in addition, several types of HAE with normal quantity and activity of C1INH (HAE‐nC1INH) have recently been classified, which occur due to different gene ...
Inmaculada Martinez‐Saguer +3 more
wiley +1 more source
Prognostic role of myoferlin expression in patients with clear cell renal cell carcinoma [PDF]
Oncotarget, 2017 In patients with cancer, myoferlin protein hyperexpression has been correlated with poor patient prognosis. Here, we evaluated myoferlin expression in patients with clear cell renal cell carcinoma (ccRCC) and investigated the prognostic significance of myoferlin expression in these patients.One hundred and fifty-two patients with ccRCC who underwent ...
Song, Dae Hyun +9 more
openaire +2 more sources
Comparative Proteomic Analysis of Hymenolepis diminuta Cysticercoid and Adult Stages [PDF]
, 2018 Cestodiases are common parasitic diseases of animals and humans. As cestodes have complex lifecycles, hexacanth larvae, metacestodes (including cysticercoids), and adults produce proteins allowing them to establish invasion and to survive in the hostile ...
Bien, Justyna +6 more
core +2 more sources
Immunogenicity and Safety of Anti-SARS-CoV-2 mRNA Vaccines in a Cohort of Patients with Hereditary Angioedema [PDF]
, 2023 Many factors may trigger hereditary angioedema (HAE) attacks. This study aims to gain insights into the benefits and potential risks of COVID-19 vaccination in HAE patients, focusing particularly on the possibility of triggering attacks.
Alessandro Furno +8 more
core +1 more source
Breast Cancer Cell Adhesion Strength Following Lentivirus-Mediated Myoferlin Depletion [PDF]
, 2011 This project has earned the author the BME Senior Research Achievement AwardThe purpose of this project was to quantify the effect of lentiviral-based knockdown of myoferlinon the adhesion and spreading of MDA-MB-231 human breast cancer cells ...
Bechel, Meagan
core