Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model [PDF]
, 2007 During spermatogenesis, extensive restructuring takes place at the Sertoli-Sertoli and Sertoli-germ cell interface, which is regulated via intriguing interactions among cytokines, proteases, protease inhibitors, kinases, phosphatases, and transcription ...
Cheng, CY, Lee, WWM, Mruk, DD, Xia, W
core +1 more source
Algorithms in Allergy: Hereditary Angioedema
Allergy, EarlyView.
Konrad Bork +3 more
wiley +1 more source
Targeting factor XIIa for therapeutic interference with hereditary angioedema
Journal of Internal Medicine, Volume 296, Issue 4, Page 311-326, October 2024.Abstract Hereditary angioedema (HAE) is a rare, potentially life‐threatening genetic disorder characterized by recurrent attacks of swelling. Local vasodilation and vascular leakage are stimulated by the vasoactive peptide bradykinin, which is excessively produced due to dysregulation of the activated factor XII (FXIIa)‐driven kallikrein–kinin system ...
Danny M. Cohn, Thomas Renné
wiley +1 more source
Homologous C2A Domains of Myoferlin and Dysferlin have Distinct Lipid Binding Specificities [PDF]
Biophysical Journal, 2017 Myoferlin and dysferlin are members of the ferlin protein family, and both are known to play an essential role in membrane fusion events and membrane repair. They are homologous multi-C2 domain proteins that are highly expressed in skeletal and cardiac muscle cells, and to a lesser degree, in brain, kidney, lung, and placenta cells.
Faraz Harsini +5 more
openaire +1 more source
Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation
Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.Abstract Hypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on cellular metabolism. As such, hypoxia is an important contributor to cancer progression and is associated with a poor prognosis.
Joël E. J. Beaumont +9 more
wiley +1 more source
Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes
Oncotarget, 2016 Exosomes are communication mediators participating in the intercellular exchange of proteins, metabolites and nucleic acids. Recent studies have demonstrated that exosomes are characterized by a unique proteomic composition that is distinct from the cellular one.
Blomme, Arnaud +11 more
openaire +3 more sources
Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins [PDF]
, 2016 © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Ferlins are an ancient family of Ca2+-binding, multi-C2 domain vesicle fusion proteins.
Cooper, ST +4 more
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Mitochondrial fusion–fission dynamics and its involvement in colorectal cancer
Molecular Oncology, Volume 18, Issue 5, Page 1058-1075, May 2024.Disruption of the mitochondrial fusion–fission dynamics balance plays a dual role in colorectal cancer development. Mitochondrial fission promotes cancer cell proliferation, invasion, migration, and chemoresistance, while excessive fission induces apoptosis.
Zihong Wu +5 more
wiley +1 more source
On the role of dysferlin in striated muscle: membrane repair, t‐tubules and Ca2+ handling
The Journal of Physiology, Volume 602, Issue 9, Page 1893-1910, 1 May 2024.Abstract figure legend Cardiac and skeletal muscle share many structural and functional similarities and are both classified as striated muscle. Dysferlin plays a diverse role in supporting healthy striated muscle physiology. Due to its protective and regenerative capabilities, dysferlin is particularly important in response to muscle stress or damage.
C. J. Quinn +3 more
wiley +1 more source
Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber ‘cell highways’ [PDF]
, 2014 BACKGROUND: Aggressive metastatic breast cancer cells seemingly evade surgical resection and current therapies, leading to colonization in distant organs and tissues and poor patient prognosis.
Aaron Short +6 more
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