Results 91 to 100 of about 1,181 (166)

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

Medicinal Research Reviews, Volume 44, Issue 6, Page 2472-2509, November 2024.
Abstract Previously, lysosomes were primarily referred to as the digestive organelles and recycling centers within cells. Recent discoveries have expanded the lysosomal functional scope and revealed their critical roles in nutrient sensing, epigenetic regulation, plasma membrane repair, lipid transport, ion homeostasis, and cellular stress response ...
Yuchen He, Yishu Fan, Xenab Ahmadpoor, Yumin Wang, Zhong Alan Li, Weihong Zhu, Hang Lin   +6 more
wiley   +1 more source

Dysferlin and myoferlin expression in human airway epithelial cells and fibroblasts. [PDF]

, 2012
Total cell lysates from primary human lung parenchymal fibroblasts (PF), bronchial fibroblast (BrF), airway epithelial cells derived from normal donor lung tissues (D1–D5), bovine aortic endothelial cell (BAEC), human fetal lung fibroblasts (HFL) and ...
Tillie-Louise Hackett (92016), Furquan Shaheen (152799), Pascal Bernatchez (152801), Cleo Leung (152795)   +3 more
core   +1 more source

Targeting factor XIIa for therapeutic interference with hereditary angioedema

Journal of Internal Medicine, Volume 296, Issue 4, Page 311-326, October 2024.
Abstract Hereditary angioedema (HAE) is a rare, potentially life‐threatening genetic disorder characterized by recurrent attacks of swelling. Local vasodilation and vascular leakage are stimulated by the vasoactive peptide bradykinin, which is excessively produced due to dysregulation of the activated factor XII (FXIIa)‐driven kallikrein–kinin system ...
Danny M. Cohn, Thomas Renné
wiley   +1 more source

Myoferlin controls mitochondrial structure in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and the third leading cause of cancer related death. Therapeutic options remain very limited and are still based on classical chemotherapies.
Durieux, Florence, Delvenne, Philippe, Costanza, Brunella, Bettendorff, Lucien, Bellahcene, Akeila, Peulen, Olivier, Hennequière, Vincent, LOVINFOSSE, Pierre, Castronovo, Vincenzo, Peiffer, Raphaël, Hustinx, Roland, Nokin, Marie-Julie, Herfs, Michael, GOFFLOT, Stéphanie, Brohée, Laura, Bellier, Justine, Deroanne, Christophe, Rademaker, Gilles   +17 more
core  

Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin [PDF]

, 2019
International audienceDysferlin has been implicated in acute membrane repair processes, whereas myoferlin's activity is maximal during the myoblast fusion stage of early skeletal muscle cell development.
Anne M. Rice, Turtoi, Andrei, Kerry L. Fuson, Edwin R. Chapman, Chapman, Edwin, Faraz M. Harsini, Chebrolu, Sukanya, Harsini, Faraz, Bradberry, Mazdak, Rice, Anne, Fuson, Kerry, Sukanya Chebrolu, R. Bryan Sutton, Mazdak Bradberry, Anthony A. Bui, Bui, Anthony, Sutton, R. Bryan, Andrei Turtoi   +17 more
core   +1 more source

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Hypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on cellular metabolism. As such, hypoxia is an important contributor to cancer progression and is associated with a poor prognosis.
Joël E. J. Beaumont, Lydie M. O. Barbeau, Jinzhe Ju, Kim G. Savelkouls, Freek G. Bouwman, Marijke I. Zonneveld, Annelies Bronckaers, Kim R. Kampen, Tom G. H. Keulers, Kasper M. A. Rouschop   +9 more
wiley   +1 more source

Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis. [PDF]

, 2019
peer reviewedColon adenocarcinoma is the third most commonly diagnosed cancer and the second deadliest one. Metabolic reprogramming, described as an emerging hallmark of malignant cells, includes the predominant use of glycolysis to produce energy ...
Castronovo, Vincenzo, Peiffer, Raphaël, Herfs, Michael, Habraken, Yvette, Delvenne, Philippe, Bellier, Justine, Rademaker, Gilles, Agirman, Ferman, Maloujahmoum, Naïma, Costanza, Brunella, Bellahcene, Akeila, Peulen, Olivier   +11 more
core   +1 more source

Mitochondrial fusion–fission dynamics and its involvement in colorectal cancer

Molecular Oncology, Volume 18, Issue 5, Page 1058-1075, May 2024.
Disruption of the mitochondrial fusion–fission dynamics balance plays a dual role in colorectal cancer development. Mitochondrial fission promotes cancer cell proliferation, invasion, migration, and chemoresistance, while excessive fission induces apoptosis.
Zihong Wu, Chong Xiao, Fang Li, Wenbo Huang, Fengming You, Xueke Li   +5 more
wiley   +1 more source

On the role of dysferlin in striated muscle: membrane repair, t‐tubules and Ca2+ handling

The Journal of Physiology, Volume 602, Issue 9, Page 1893-1910, 1 May 2024.
Abstract figure legend Cardiac and skeletal muscle share many structural and functional similarities and are both classified as striated muscle. Dysferlin plays a diverse role in supporting healthy striated muscle physiology. Due to its protective and regenerative capabilities, dysferlin is particularly important in response to muscle stress or damage.
C. J. Quinn, E. J. Cartwright, A. W. Trafford, K. M. Dibb   +3 more
wiley   +1 more source

Site-specific glycosylation of Sec24D and myoferlin recruit ERGIC to ER exit sites for collagen trafficking

Nature Communications
Coat protein complex II (COPII) mediates anterograde trafficking from the endoplasmic reticulum (ER). While the core COPII machinery is well-characterized, how cells regulate COPII to accommodate large cargoes, including collagens, remains incompletely ...
Tetsuya Hirata, Dharmendra Choudhary, Quyen Nguyen, Brittany J. Bisnett, Erik J. Soderblom, Ela W. Knapik, Michael Boyce   +6 more
doaj   +1 more source