Results 81 to 90 of about 1,180 (165)

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

Medicinal Research Reviews, Volume 44, Issue 6, Page 2472-2509, November 2024.
Abstract Previously, lysosomes were primarily referred to as the digestive organelles and recycling centers within cells. Recent discoveries have expanded the lysosomal functional scope and revealed their critical roles in nutrient sensing, epigenetic regulation, plasma membrane repair, lipid transport, ion homeostasis, and cellular stress response ...
Yuchen He, Yishu Fan, Xenab Ahmadpoor, Yumin Wang, Zhong Alan Li, Weihong Zhu, Hang Lin   +6 more
wiley   +1 more source

Targeting factor XIIa for therapeutic interference with hereditary angioedema

Journal of Internal Medicine, Volume 296, Issue 4, Page 311-326, October 2024.
Abstract Hereditary angioedema (HAE) is a rare, potentially life‐threatening genetic disorder characterized by recurrent attacks of swelling. Local vasodilation and vascular leakage are stimulated by the vasoactive peptide bradykinin, which is excessively produced due to dysregulation of the activated factor XII (FXIIa)‐driven kallikrein–kinin system ...
Danny M. Cohn, Thomas Renné
wiley   +1 more source

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Hypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on cellular metabolism. As such, hypoxia is an important contributor to cancer progression and is associated with a poor prognosis.
Joël E. J. Beaumont, Lydie M. O. Barbeau, Jinzhe Ju, Kim G. Savelkouls, Freek G. Bouwman, Marijke I. Zonneveld, Annelies Bronckaers, Kim R. Kampen, Tom G. H. Keulers, Kasper M. A. Rouschop   +9 more
wiley   +1 more source

Mitochondrial fusion–fission dynamics and its involvement in colorectal cancer

Molecular Oncology, Volume 18, Issue 5, Page 1058-1075, May 2024.
Disruption of the mitochondrial fusion–fission dynamics balance plays a dual role in colorectal cancer development. Mitochondrial fission promotes cancer cell proliferation, invasion, migration, and chemoresistance, while excessive fission induces apoptosis.
Zihong Wu, Chong Xiao, Fang Li, Wenbo Huang, Fengming You, Xueke Li   +5 more
wiley   +1 more source

Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis. [PDF]

, 2019
peer reviewedColon adenocarcinoma is the third most commonly diagnosed cancer and the second deadliest one. Metabolic reprogramming, described as an emerging hallmark of malignant cells, includes the predominant use of glycolysis to produce energy ...
Castronovo, Vincenzo, Peiffer, Raphaël, Herfs, Michael, Habraken, Yvette, Delvenne, Philippe, Bellier, Justine, Rademaker, Gilles, Agirman, Ferman, Maloujahmoum, Naïma, Costanza, Brunella, Bellahcene, Akeila, Peulen, Olivier   +11 more
core   +1 more source

On the role of dysferlin in striated muscle: membrane repair, t‐tubules and Ca2+ handling

The Journal of Physiology, Volume 602, Issue 9, Page 1893-1910, 1 May 2024.
Abstract figure legend Cardiac and skeletal muscle share many structural and functional similarities and are both classified as striated muscle. Dysferlin plays a diverse role in supporting healthy striated muscle physiology. Due to its protective and regenerative capabilities, dysferlin is particularly important in response to muscle stress or damage.
C. J. Quinn, E. J. Cartwright, A. W. Trafford, K. M. Dibb   +3 more
wiley   +1 more source

Advances in separation and identification of biologically important milk proteins and peptides

ELECTROPHORESIS, Volume 45, Issue 1-2, Page 101-119, January 2024.
Abstract Milk is a rich source of biologically important proteins and peptides. In addition, milk contains a variety of extracellular vesicles (EVs), including exosomes, that carry their own proteome cargo. EVs are essential for cell–cell communication and modulation of biological processes. They act as nature carriers of bioactive proteins/peptides in
Miroslava Stastna
wiley   +1 more source

No effect of dysferlin or myoferlin knockdown on VEGFR-2 and caveolin-1 expression.

, 2012
16HBE cells were transfected with oligofectamine transfection reagent (TF con), scrambled siRNA (S), dysferlin or myoferlin siRNA at 50 nM, 75 nM and 100 nM for 72 h.
Tillie-Louise Hackett (92016), Furquan Shaheen (152799), Pascal Bernatchez (152801), Cleo Leung (152795)   +3 more
core   +1 more source

Chemical crosslinking analysis of β-dystroglycan in dystrophin-deficient skeletal muscle [version 2; peer review: 2 approved]

HRB Open Research, 2018
Background: In Duchenne muscular dystrophy, primary abnormalities in the membrane cytoskeletal protein dystrophin trigger the loss of sarcolemmal linkage between the extracellular matrix component laminin-211 and the intracellular cortical actin membrane
Sandra Murphy, Margit Zweyer, Rustam R. Mundegar, Dieter Swandulla, Kay Ohlendieck   +4 more
doaj   +1 more source