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Pancreatic Cancer [PDF]

open access: yesCa-A Cancer Journal for Clinicians, 1981
As a result of increased funding in the past few years, carcinoma of the pancreas has received increased investigative attention. A substantial body of epidemiologic data has been recorded, which may ultimately provide leads that identify an "at risk" population.
Isidore Cohn
exaly   +3 more sources

Pancreatic cancer [PDF]

open access: yesCa-A Cancer Journal for Clinicians, 1994
Pancreatic cancer is a devastating disease for the patient and presents challenging diagnostic and management problems for the physician. A range of serologic and radiologic studies are available for evaluation and staging of this disease. However, invasive studies, including laparotomy, are often necessary to establish the diagnosis and resectability.
Michel M Murr   +2 more
exaly   +3 more sources

Pancreatic Cancer [PDF]

open access: yesCa-A Cancer Journal for Clinicians, 1982
exaly   +3 more sources

Hypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancer

open access: yesEBioMedicine, 2022
Summary: Background: Previously, we uncovered a patient subgroup with highly malignant pancreatic cancer with serum markers CEA+/CA125+/CA19-9 ≥ 1000 U/mL (triple-positive, TP).
Longyun Ye   +14 more
doaj   +1 more source

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

open access: yesJournal of Hematology & Oncology, 2022
Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of ...
Xuhui Tong   +8 more
doaj   +1 more source

Pancreatic cancer

open access: yesTranslational Gastroenterology and Hepatology, 2020
Pancreatic cancer is a highly fatal disease with a 5-year survival rate of approximately 10% in the USA, and it is becoming an increasingly common cause of cancer mortality. Risk factors for developing pancreatic cancer include family history, obesity, type 2 diabetes, and tobacco use.
Helmut, Friess, Florian, Scheufele
openaire   +4 more sources

Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma

open access: yesOncogenesis, 2022
Pancreatic ductal adenocarcinoma (PDAC) is a well-known lethal and heterogeneous disease. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) is an important mutagenic driver that has seldom been investigated in PDAC. Therefore, this
Yunzhen Qian   +13 more
doaj   +1 more source

Carbohydrate antigen 125 supplements carbohydrate antigen 19-9 for the prediction of invasive intraductal papillary mucinous neoplasms of the pancreas

open access: yesWorld Journal of Surgical Oncology, 2022
Background Intraductal papillary mucinous neoplasms (IPMNs) are characterized by their abundant mucin production and malignant potential. IPMNs of the pancreas are mainly managed according to their radiographic indications, but this approach lacks ...
Yunzhen Qian   +12 more
doaj   +1 more source

High GFPT1 expression predicts unfavorable outcomes in patients with resectable pancreatic ductal adenocarcinoma

open access: yesWorld Journal of Surgical Oncology, 2021
Background Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is the first rate-limiting enzyme of the hexosamine biosynthesis pathway (HBP), which plays a pivotal role in the progression of pancreatic ductal adenocarcinoma (PDAC).
Yitao Gong   +11 more
doaj   +1 more source

Resected Pancreatic Cancer With N2 Node Involvement Is Refractory to Gemcitabine-Based Adjuvant Chemotherapy

open access: yesCancer Control, 2020
Lymphatic metastasis is a major determinant of the outcome of resected pancreatic cancer. Gemcitabine-based adjuvant chemotherapy can improve the outcome of resected pancreatic cancer.
Chen Liu MD, PhD   +10 more
doaj   +1 more source

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