Results 11 to 20 of about 404,404 (258)
Nature Reviews Disease Primers, 2016 Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall prognosis that has remained virtually unchanged for many decades. Currently, prevention or early diagnosis at a curable stage is exceedingly difficult; patients rarely exhibit symptoms and tumours do not display sensitive and specific markers to aid detection ...
Kleeff, J +10 more
+12 more sources
Translational Gastroenterology and Hepatology, 2020 Pancreatic cancer is a highly fatal disease with a 5-year survival rate of approximately 10% in the USA, and it is becoming an increasingly common cause of cancer mortality. Risk factors for developing pancreatic cancer include family history, obesity, type 2 diabetes, and tobacco use.
Helmut, Friess, Florian, Scheufele
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The Lancet, 2011 Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant ...
Audrey, Vincent +4 more
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CA: A Cancer Journal for Clinicians, 1981 As a result of increased funding in the past few years, carcinoma of the pancreas has received increased investigative attention. A substantial body of epidemiologic data has been recorded, which may ultimately provide leads that identify an "at risk" population.
R M, Beazley, I, Cohn
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CA: A Cancer Journal for Clinicians, 1994 Pancreatic cancer is a devastating disease for the patient and presents challenging diagnostic and management problems for the physician. A range of serologic and radiologic studies are available for evaluation and staging of this disease. However, invasive studies, including laparotomy, are often necessary to establish the diagnosis and resectability.
M M, Murr +3 more
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Nature Reviews Disease PrimersPancreatic ductal adenocarcinoma remains one of the deadliest malignancies, characterized by late diagnosis, aggressive biology and limited therapeutic success. Advances in multiagent chemotherapy have improved outcomes across disease stages, whereas precision medicine approaches are reshaping treatment paradigms.
Roth, Susanne +17 more
+6 more sources
British Journal of Pharmacology, 2014 In recent years, it has become clear that the current standard therapeutic options for pancreatic cancer are not adequate and still do not meet the criteria to cure patients suffering from this lethal disease. Although research over the past decade has shown very interesting and promising new therapeutic options for these patients, only minor clinical ...
C, Güngör +3 more
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Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective
Computational and Structural Biotechnology Journal, 2020 Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is usually diagnosed at an advanced stage when curative surgery is no longer an option.
Wu-Hu Zhang +14 more
doaj +1 more source
BMC Gastroenterology, 2023 Background The effectiveness of chemotherapy in older adult patients with biliary tract cancer (BTC) remains to be established, despite the fact that the majority of patients diagnosed with BTC tend to be aged ≥ 70 years.
Takeru Hirao +16 more
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European Journal of Surgical Oncology, 2023 The need for a common education and training track in surgical oncology across Europe has been emphasized. ESSO provides several hands-on courses for skills training and face-to-face discussions. The core curriculum provides a framework for the overall theoretical requirements in surgical oncology. The UEMS/EBSQ fellowship exam is designed to test core
Kjetil Søreide +4 more
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