PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications
Molecular Cancer, 2020 Pancreatic cancer is a highly lethal disease with a poor prognosis, and existing therapies offer only limited effectiveness. Mutation gene sequencing has shown several gene associations that may account for its carcinogenesis, revealing a promising ...
Heng Zhu +10 more
doaj +1 more source
Nationwide practice and outcomes of endoscopic biliary drainage in resectable pancreatic head and periampullary cancer [PDF]
, 2021 BACKGROUND: Guidelines advise self-expanding metal stents (SEMS) over plastic stents in preoperative endoscopic biliary drainage (EBD) for malignant extrahepatic biliary obstruction. This study aims to assess nationwide practice and outcomes.
Dutch Pancreatic Cancer Group
core
BMC Gastroenterology, 2023 Background The effectiveness of chemotherapy in older adult patients with biliary tract cancer (BTC) remains to be established, despite the fact that the majority of patients diagnosed with BTC tend to be aged ≥ 70 years.
Takeru Hirao +16 more
doaj +1 more source
Practice variation in venous resection during pancreatoduodenectomy for pancreatic cancer: A nationwide cohort study [PDF]
, 2023 Background: Practice variation exists in venous resection during pancreatoduodenectomy, but little is known about the potential causes and consequences as large studies are lacking.
Dutch Pancreatic Cancer Group
core
Molecular Cancer, 2021 Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao +9 more
doaj +1 more source
PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis
Cell Communication and Signaling, 2019 Background The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation and cell cycle control.
Yi Qin +12 more
doaj +1 more source
Diabetes and the risk of pancreatic cancer.
, 1994 BACKGROUND: Diabetes and pancreatic cancer are known to be associated, but the cause of the association and whether diabetes is a risk factor for pancreatic cancer remain controversial.
Morselli Labate AM +5 more
core +1 more source
Impact of classical and basal-like molecular subtypes on overall survival in resected pancreatic cancer in the SPACIOUS-2 multicentre study [PDF]
, 2022 BACKGROUND: The recently identified classical and basal-like molecular subtypes of pancreatic cancer impact on overall survival (OS). However, the added value of routine subtyping in both clinical practice and randomized trials is still unclear, as most ...
Dutch Pancreatic Cancer Group
core
A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma
BMC Gastroenterology, 2023 Background Pancreatic adenocarcinoma (PAAD) remains a lethal malignancy making the detection of novel prognostic biomarkers urgent. Limited studies have investigated the predictive capability of immune checkpoints in PAAD. Method Gene expression data and
Yusheng Chen +9 more
doaj +1 more source
Targeting apoptosis signaling in pancreatic cancer
, 2011 The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis.
Simone Fulda, Fulda, Simone
core +1 more source