Results 31 to 40 of about 390,233 (255)

The role of necroptosis in cancer biology and therapy

Molecular Cancer, 2019
Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem ...
Yitao Gong, Zhiyao Fan, Guopei Luo, Chao Yang, Qiuyi Huang, Kun Fan, He Cheng, Kaizhou Jin, Quanxing Ni, Xianjun Yu, Chen Liu   +10 more
doaj   +1 more source

Chronic Pancreatitis and Pancreatic Cancer [PDF]

Gastroenterology, 2014
<b><i>Background:</i></b> Pancreatic cancer (PC) is one of the most lethal diseases with an incidence rate almost equal to the rate of mortality. Chronic pancreatitis (CP) is a common chronic inflammatory disease of unknown etiology that affects the pancreas.
Bai-Rong, Li, Liang-Hao, Hu, Zhao-Shen, Li   +2 more
openaire   +4 more sources

Pancreatic Cancer Frequently Infiltrates the TRIANGLE Compartment: A Surgical Option to Prevent Local Recurrence

Annals of Surgery Open
Objective:. To evaluate the presence of pancreatic cancer cells within the TRIANGLE compartment (area between mesenteric-portal axis, celiac trunk, and superior mesenteric artery) and to determine its potential role for locoregional recurrence ...
Vera Oliveira, MD, Ingmar F. Rompen, MD, Gil Gonçalves, MD, Rafaela Rego, MD, Mireia Castillo-Martin, MD, PhD, Giuseppe R. Diaferia, PhD, Ana Alagoa João, MD, Elsa Francisco, MD, Filipe C. Borges, MD, Marta Sousa, MD, Pellin Bagci, MD, PhD, Marisa Aral, MD, Miguel F. Borges, MD, José Filipe Cunha, MD, Cristoph Berchtold, MD, Arianeb Mehrabi, MD, Peter Bailey, MD, PhD, Markus W. Büchler, MD   +17 more
doaj   +1 more source

Pancreatic resection for pancreatic cancer [PDF]

HPB, 2006
Ductal pancreatic adenocarcinoma, the most frequent malignancy of the pancreas, is characterized by retroperitoneal and perineural infiltration, early formation of multiple metastases, and resistance to most of the treatment regimens currently available.
Bachmann, Jeannine, Michalski, Christoph W., Martignoni, Marc E., Büchler, Markus W., Friess, Helmut   +4 more
openaire   +2 more sources

Pancreatitis and Pancreatic Cancer Risk

Technology in Cancer Research & Treatment, 2023
Purpose: The present retrospective study aimed to explore the relationship between pancreatitis and pancreatic cancer in the population cohort of the UK Biobank (UKB) ( https://www.ukbiobank.ac.uk ). Methods: From the 500 thousand population cohort of UKB, according to the age and gender of patients with pancreatic cancer 1:10, matching the control ...
Dong-Mei Ma, Xiao-Wu Dong, Xiao Han, Zhi Ling, Guo-Tao Lu, Yun-Yun Sun, Xu-Dong Yin   +6 more
openaire   +3 more sources

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis

Cell Death and Disease
N6-methyladenosine (m6A) modification has emerged as a common chemical modification in epigenetic regulation. However, whether this m6A modification is involved in glycolysis metabolism in pancreatic ductal adenocarcinoma (PDAC) remains elusive ...
Zhen Tan, Jianhui Yang, Yueyue Chen, Heng Zhu, Xiaomeng Liu, He Xu, Qingcai Meng, Mingming Xiao, Rong Tang, Zeyin Rong, Xianjun Yu, Chen Liang, Jin Xu   +12 more
doaj   +1 more source

Turning up the heat on non-immunoreactive tumors: autophagy influences the immune microenvironment in pancreatic cancer

BMC Medical Genomics, 2022
Background Autophagy regulators play important roles in the occurrence and development of a variety of tumors and are involved in immune regulation and drug resistance.
Si-Yuan Lu, Jie Hua, Jiang Liu, Miao-Yan Wei, Chen Liang, Qing-Cai Meng, Bo Zhang, Xian Jun Yu, Wei Wang, Jin Xu   +9 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer

BMC Cancer, 2022
Background RNA methylation refers to a form of methyl modification in RNA that modulates various epigenetic alterations. Mounting studies have focused on its potential mechanisms in cancer initiation and progression.
Siyuan Lu, Jie Hua, Jiang Liu, Miaoyan Wei, Chen Liang, Qingcai Meng, Bo Zhang, Xianjun Yu, Wei Wang, Jin Xu   +9 more
doaj   +1 more source