Results 51 to 60 of about 457,954 (260)

Pancreatic Cancer Frequently Infiltrates the TRIANGLE Compartment: A Surgical Option to Prevent Local Recurrence

Annals of Surgery Open
Objective:. To evaluate the presence of pancreatic cancer cells within the TRIANGLE compartment (area between mesenteric-portal axis, celiac trunk, and superior mesenteric artery) and to determine its potential role for locoregional recurrence ...
Vera Oliveira, MD, Ingmar F. Rompen, MD, Gil Gonçalves, MD, Rafaela Rego, MD, Mireia Castillo-Martin, MD, PhD, Giuseppe R. Diaferia, PhD, Ana Alagoa João, MD, Elsa Francisco, MD, Filipe C. Borges, MD, Marta Sousa, MD, Pellin Bagci, MD, PhD, Marisa Aral, MD, Miguel F. Borges, MD, José Filipe Cunha, MD, Cristoph Berchtold, MD, Arianeb Mehrabi, MD, Peter Bailey, MD, PhD, Markus W. Büchler, MD   +17 more
doaj   +1 more source

Turning up the heat on non-immunoreactive tumors: autophagy influences the immune microenvironment in pancreatic cancer

BMC Medical Genomics, 2022
Background Autophagy regulators play important roles in the occurrence and development of a variety of tumors and are involved in immune regulation and drug resistance.
Si-Yuan Lu, Jie Hua, Jiang Liu, Miao-Yan Wei, Chen Liang, Qing-Cai Meng, Bo Zhang, Xian Jun Yu, Wei Wang, Jin Xu   +9 more
doaj   +1 more source

Short- and Long-Term Outcomes of Pancreatic Cancer Resection in Elderly Patients: A Nationwide Analysis [PDF]

, 2022
Background: The number of elderly patients with pancreatic cancer is growing, however clinical data on the short-term outcomes, rate of adjuvant chemotherapy, and survival in these patients are limited and we therefore performed a nationwide analysis ...
Dutch Pancreatic Cancer Group
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis

Cell Death and Disease
N6-methyladenosine (m6A) modification has emerged as a common chemical modification in epigenetic regulation. However, whether this m6A modification is involved in glycolysis metabolism in pancreatic ductal adenocarcinoma (PDAC) remains elusive ...
Zhen Tan, Jianhui Yang, Yueyue Chen, Heng Zhu, Xiaomeng Liu, He Xu, Qingcai Meng, Mingming Xiao, Rong Tang, Zeyin Rong, Xianjun Yu, Chen Liang, Jin Xu   +12 more
doaj   +1 more source

Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer

BMC Cancer, 2022
Background RNA methylation refers to a form of methyl modification in RNA that modulates various epigenetic alterations. Mounting studies have focused on its potential mechanisms in cancer initiation and progression.
Siyuan Lu, Jie Hua, Jiang Liu, Miaoyan Wei, Chen Liang, Qingcai Meng, Bo Zhang, Xianjun Yu, Wei Wang, Jin Xu   +9 more
doaj   +1 more source

Pancreatic Cancer in Chronic Pancreatitis [PDF]

Indian Journal of Surgical Oncology, 2015
Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. The strength of this association varies between various causes of pancreatitis, with hereditary and tropical pancreatitis more likely to result in malignancy. Pathogenesis may involve genetic factors, diabetes, smoking and alcohol consumption.
Puneet, Dhar, S, Kalghatgi, Vivek, Saraf
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The promising role of noncoding RNAs in cancer-associated fibroblasts: an overview of current status and future perspectives

Journal of Hematology & Oncology, 2020
As the most important component of the stromal cell population in the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) are crucial players in tumor initiation and progression. The interaction between CAFs and tumor cells, as well as the
Zengli Fang, Jin Xu, Bo Zhang, Wei Wang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi   +9 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source