Results 71 to 80 of about 5,871,156 (346)

Download Entire Issue: Gibbon Surgical Review, Volume 1, Issue 2, 2018 [PDF]

, 2018
Table of Contents Forward by Charles J. Yeo, MD, FACS PERSPECTIVE - An Interview with Dr. Theresa Yeo, Co-Director of the Jefferson Pancreas Tumor Registry (JPTR) A PGY-1\u27s Perspective: Conducting Pancreatic Cancer Research as a Medical Student ...

core   +1 more source

LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway

Cancer Research, 2021
These findings show that a reciprocal feedback of HIF1A-AS1 and HIF1α promotes gemcitabine resistance of pancreatic cancer, which provides an applicable therapeutic target.
Feng-yu Xu, Mengqi Huang, Qing-yong Chen, Y. Niu, Yuhang Hu, Ping Hu, Ding Chen, Chi He, Kang Huang, Z. Zeng, Jiang Tang, Fan Wang, Yong Zhao, Chun-you Wang, Gang Zhao   +14 more
semanticscholar   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis

Cell Death and Disease
N6-methyladenosine (m6A) modification has emerged as a common chemical modification in epigenetic regulation. However, whether this m6A modification is involved in glycolysis metabolism in pancreatic ductal adenocarcinoma (PDAC) remains elusive ...
Zhen Tan, Jianhui Yang, Yueyue Chen, Heng Zhu, Xiaomeng Liu, He Xu, Qingcai Meng, Mingming Xiao, Rong Tang, Zeyin Rong, Xianjun Yu, Chen Liang, Jin Xu   +12 more
doaj   +1 more source

The promising role of noncoding RNAs in cancer-associated fibroblasts: an overview of current status and future perspectives

Journal of Hematology & Oncology, 2020
As the most important component of the stromal cell population in the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) are crucial players in tumor initiation and progression. The interaction between CAFs and tumor cells, as well as the
Zengli Fang, Jin Xu, Bo Zhang, Wei Wang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi   +9 more
doaj   +1 more source

Identification of the Roles of a Stemness Index Based on mRNA Expression in the Prognosis and Metabolic Reprograming of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundCancer stem cells (CSCs) are widely thought to contribute to the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC). CSCs share biological features with adult stem cells, such as longevity, self-renewal capacity, differentiation, drug ...
Rong Tang, Rong Tang, Rong Tang, Rong Tang, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi   +43 more
doaj   +1 more source

Worldwide Burden of, Risk Factors for, and Trends in Pancreatic Cancer.

Gastroenterology, 2020
BACKGROUND & AIMS We evaluated global and regional burdens of, risk factors for, and epidemiologic trends in pancreatic cancer among groups of different sexes and ages.
Junjie Huang, Veeleah Lok, C. Ngai, Lin Zhang, Jinqiu Yuan, X. Lao, K. Ng, C. Chong, Zhi‐Jie Zheng, M. Wong   +9 more
semanticscholar   +1 more source

Pancreatic Cancer in Chronic Pancreatitis [PDF]

Indian Journal of Surgical Oncology, 2015
Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. The strength of this association varies between various causes of pancreatitis, with hereditary and tropical pancreatitis more likely to result in malignancy. Pathogenesis may involve genetic factors, diabetes, smoking and alcohol consumption.
Puneet, Dhar, S, Kalghatgi, Vivek, Saraf
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway

Frontiers in Oncology, 2022
BackgroundThe neddylation pathway is aberrantly overactivated in multiple human cancers and has been indicated as an effective target for anticancer therapy in clinical trials.
Junfeng Xu, Junfeng Xu, Junfeng Xu, Junfeng Xu, Zheng Li, Zheng Li, Zheng Li, Zheng Li, Qifeng Zhuo, Qifeng Zhuo, Qifeng Zhuo, Qifeng Zhuo, Zeng Ye, Zeng Ye, Zeng Ye, Zeng Ye, Guixiong Fan, Guixiong Fan, Guixiong Fan, Guixiong Fan, Heli Gao, Heli Gao, Heli Gao, Heli Gao, Shunrong Ji, Shunrong Ji, Shunrong Ji, Shunrong Ji, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Wensheng Liu, Wensheng Liu, Wensheng Liu, Wensheng Liu, Wenyan Xu, Wenyan Xu, Wenyan Xu, Wenyan Xu   +43 more
doaj   +1 more source