Results 41 to 50 of about 390,233 (255)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

The promising role of noncoding RNAs in cancer-associated fibroblasts: an overview of current status and future perspectives

Journal of Hematology & Oncology, 2020
As the most important component of the stromal cell population in the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) are crucial players in tumor initiation and progression. The interaction between CAFs and tumor cells, as well as the
Zengli Fang, Jin Xu, Bo Zhang, Wei Wang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi   +9 more
doaj   +1 more source

Deciphering the Prognostic Implications of the Components and Signatures in the Immune Microenvironment of Pancreatic Ductal Adenocarcinoma

Frontiers in Immunology, 2021
Background: The treatment modalities for pancreatic ductal adenocarcinoma (PDAC) are limited and unsatisfactory. Although many novel drugs targeting the tumor microenvironment, such as immune checkpoint inhibitors, have shown promising efficacy for some ...
Rong Tang, Rong Tang, Rong Tang, Rong Tang, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi   +43 more
doaj   +1 more source

Pancreatic Cancer in Chronic Pancreatitis [PDF]

Indian Journal of Surgical Oncology, 2015
Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. The strength of this association varies between various causes of pancreatitis, with hereditary and tropical pancreatitis more likely to result in malignancy. Pathogenesis may involve genetic factors, diabetes, smoking and alcohol consumption.
Puneet, Dhar, S, Kalghatgi, Vivek, Saraf
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification of the Roles of a Stemness Index Based on mRNA Expression in the Prognosis and Metabolic Reprograming of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundCancer stem cells (CSCs) are widely thought to contribute to the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC). CSCs share biological features with adult stem cells, such as longevity, self-renewal capacity, differentiation, drug ...
Rong Tang, Rong Tang, Rong Tang, Rong Tang, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi   +43 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer

Cell Death and Disease, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant digestive tract tumor with limited clinical treatments. Transforming acidic coiled-coil-containing protein 3 (TACC3) is a component of the centrosome axis and a member of the TACC family ...
Saimeng Shi, Duancheng Guo, Longyun Ye, Tianjiao Li, Qinglin Fei, Mengxiong Lin, Xianjun Yu, Kaizhou Jin, Weiding Wu   +8 more
doaj   +1 more source

Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway

Frontiers in Oncology, 2022
BackgroundThe neddylation pathway is aberrantly overactivated in multiple human cancers and has been indicated as an effective target for anticancer therapy in clinical trials.
Junfeng Xu, Junfeng Xu, Junfeng Xu, Junfeng Xu, Zheng Li, Zheng Li, Zheng Li, Zheng Li, Qifeng Zhuo, Qifeng Zhuo, Qifeng Zhuo, Qifeng Zhuo, Zeng Ye, Zeng Ye, Zeng Ye, Zeng Ye, Guixiong Fan, Guixiong Fan, Guixiong Fan, Guixiong Fan, Heli Gao, Heli Gao, Heli Gao, Heli Gao, Shunrong Ji, Shunrong Ji, Shunrong Ji, Shunrong Ji, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Wensheng Liu, Wensheng Liu, Wensheng Liu, Wensheng Liu, Wenyan Xu, Wenyan Xu, Wenyan Xu, Wenyan Xu   +43 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source