Results 21 to 30 of about 5,871,156 (346)

Pancreatic Cancer: A Review of Current Treatment and Novel Therapies.

Journal of investigative surgery, 2022
Pancreatic cancer is one of the leading causes for cancer-related deaths in the United States. Majority of patients present with unresectable or metastatic disease.
H. Kolbeinsson, S. Chandana, G. Wright, M. Chung   +3 more
semanticscholar   +1 more source

Targeting hypoxic tumor microenvironment in pancreatic cancer

Journal of Hematology & Oncology, 2021
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic cancer harbors ample stromal cells and abundant extracellular matrix but ...
Jinxin Tao, Gang Yang, Wenchuan Zhou, J. Qiu, Guangyu Chen, W. Luo, F. Zhao, L. You, Lianfang Zheng, Taiping Zhang, Yupei Zhao   +10 more
semanticscholar   +1 more source

Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3): study protocol for a multicenter randomized controlled trial

BMC Cancer, 2023
Background Surgical resection followed by adjuvant mFOLFIRINOX (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) is currently the standard of care for patients with resectable pancreatic cancer.
J. L. Dam, E. Verkolf, E. Dekker, B. Bonsing, S. Bratlie, L. Brosens, O. Busch, L. M. J. W. Driel, C. H. Eijck, S. Feshtali, P. Ghorbani, D. Groot, J. Groot, B. Haberkorn, I. H. Hingh, B. Holt, T. Karsten, M. Kolk, K. Labori, M. Liem, O. Loosveld, I. Molenaar, M. Polée, H. C. Santvoort, J. D. Vos – Geelen, M. Wumkes, G. Tienhoven, M. Homs, M. Besselink, J. Wilmink, B. Groot Koerkamp, for the Dutch Pancreatic Cancer Group   +31 more
semanticscholar   +1 more source

Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective

Computational and Structural Biotechnology Journal, 2020
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is usually diagnosed at an advanced stage when curative surgery is no longer an option.
Wu-Hu Zhang, Wen-Quan Wang, Xuan Han, He-Li Gao, Tian-Jiao Li, Shuai-Shuai Xu, Shuo Li, Hua-Xiang Xu, Hao Li, Long-Yun Ye, Xuan Lin, Chun-Tao Wu, Jiang Long, Xian-Jun Yu, Liang Liu   +14 more
doaj   +1 more source

Exome-wide association study of pancreatic cancer risk [PDF]

, 2018
We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic
Biankin, Andrew, Borgida, Ayelet, Cleary, Sean, Connor, Ashton A., Cook, Natalie, Denroche, Robert E., Gallinger, Steven, Grant, Robert C., Grimmond, Sean M., Klein, Alison P., Lemire, Mathieu, Moore, Malcolm, Peterson, Gloria, Roberts, Nicholas J., Smith, Alyssa L., Stein, Lincoln, Virtanen, Carl, Wilson, Julie M., Zogopolous, George   +18 more
core   +1 more source

Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review

Cancer Communications, 2021
Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to its highly aggressive characteristics and lack of typical early symptoms ...
Jinshou Yang, Ruiyuan Xu, Chengcheng Wang, J. Qiu, B. Ren, L. You   +5 more
semanticscholar   +1 more source

Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma

Journal of Hematology & Oncology, 2020
Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve as targets in precise therapy.
Yunzhen Qian, Yitao Gong, Zhiyao Fan, Guopei Luo, Qiuyi Huang, Shengming Deng, He Cheng, Kaizhou Jin, Quanxing Ni, Xianjun Yu, Chen Liu   +10 more
doaj   +1 more source

From the Immune Profile to the Immunoscore: Signatures for Improving Postsurgical Prognostic Prediction of Pancreatic Neuroendocrine Tumors

Frontiers in Immunology, 2021
ObjectiveImmune infiltration plays an important role in tumor development and progression and shows promising prognostic value in numerous tumors. In this study, we aimed to identify the role of immune infiltration in pancreatic neuroendocrine tumors ...
Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi, Si Shi   +49 more
doaj   +1 more source

Pancreatic cancer-associated diabetes mellitus: an open field for proteomic applications. [PDF]

, 2005
Background: Diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases. Clinical, epidemiological, and experimental data indicate that pancreatic cancer causes diabetes mellitus by releasing soluble mediators which interfere ...
BALDO G, BASSO D, FLAGIELLO A, FOGAR P, GIUNCO S, GRECO E, NAVAGLIA F, PEDRAZZOLI S, PLEBANI M., PUCCI, PIETRO, VALERIO A, ZAMBON CF   +11 more
core   +1 more source

Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer.

Cancer Cell, 2022
In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts, pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1).
Yang Chen, Sujuan Yang, Jena L. Tavormina, D. Tampe, M. Zeisberg, Huamin Wang, Krishnan K. Mahadevan, Chang-Jiun Wu, H. Sugimoto, Chia-Chi Chang, R. Jenq, Kathleen M. McAndrews, R. Kalluri   +12 more
semanticscholar   +1 more source