Results 51 to 60 of about 1,281 (134)

Loss of myoferlin redirects breast cancer cell motility towards collective migration.

PLoS ONE, 2014
Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal transition (EMT) and migrate as single cells.
Leonithas I Volakis, Ruth Li, William E Ackerman, Cosmin Mihai, Meagan Bechel, Taryn L Summerfield, Christopher S Ahn, Heather M Powell, Rachel Zielinski, Thomas J Rosol, Samir N Ghadiali, Douglas A Kniss   +11 more
doaj   +1 more source

Myoferlin is a key regulator of EGFR activity in breast cancer. [PDF]

, 2013
peer reviewedMyoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its expression in and contributions to cancer ...
Gilles, Christine, Turtoi, Andrei, De Pauw, Edwin, Hennequière, Vincent, Castronovo, Vincenzo, Noël, Agnès, Blomme, Arnaud, Delvenne, Philippe, Peixoto, Paul, BIANCHI, Elettra, LIFRANGE, Eric, Bellahcene, Akeila   +11 more
core   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page e1034-e1044, August 2026.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

Garadacimab zur Langzeitprophylaxe bei hereditärem Angioödem

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page 1034-1046, August 2026.
Zusammenfassung Das hereditäre Angioödem (Hereditary angioedema, HAE), eine seltene und belastende Erkrankung, die durch rezidivierende und spontane Gewebeschwellungsattacken gekennzeichnet ist, weist einen hohen ungedeckten therapeutischen Bedarf auf, da Patienten unter aktuellen prophylaktischen Behandlungen eine unzureichende Krankheitskontrolle ...
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

Characterization of the Myoferlin transgenic mice. A

, 2012
/Schematic representation of the Myof construct and Hprt targeted allele. B/Quantitative RT-PCR for myoferlin expression in muscles of WT and TgMyof revealed a 200-fold greater expression in the transgenic.
Carinne Roudaut (162223), William Lostal (162211), Laurence Suel (162256), Daniel Stockholm (25425), Martin Krahn (162235), Rumaisa Bashir (162275), Marina Pryadkina (162240), Nicolas Levy (1708774), Marc Bartoli (162219), Robert J. Bloch (162268), Isabelle Richard (162281), Perrine Borel (162248), Joseph A. Roche (162262), Nathalie Bourg (162229)   +13 more
core   +1 more source

Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes [PDF]

, 2016
peer reviewedExosomes are communication mediators participating in the intercellular exchange of proteins, metabolites and nucleic acids. Recent studies have demonstrated that exosomes are characterized by a unique proteomic composition that is distinct ...
De Pauw, Edwin, Turtoi, Andrei, Struman, Ingrid, Blomme, Arnaud, Fontaine, Marie, Fahmy, Karim, Peulen, Olivier, Costanza, Brunella, Bellahcene, Akeila, Thiry, Marc, Castronovo, Vincenzo, Baiwir, Dominique, Castronovo, Vincent   +12 more
core   +1 more source

Myoferlin, a new autophagy player in pancreatic cancer cells

, 2017
Despite intensive research, Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the deadliest forms of cancer. Early-stage of the disease is clinically silent and the diagnosis of the disease is mostly made at an advanced stage.
Hennequière, Vincent, Castronovo, Vincenzo, Peixoto, Paul, Rademaker, Gilles, Bellahcene, Akeila, Peulen, Olivier   +5 more
core   +1 more source

Treatment of Hereditary Angioedema With Plasma‐Derived C1 Inhibitor: A Review

Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.
ABSTRACT Hereditary angioedema (HAE) is clinically characterized by recurrent episodes of localized edema. HAE typically occurs due to a deficiency of functional C1 inhibitor (C1INH, HAE‐C1INH); in addition, several types of HAE with normal quantity and activity of C1INH (HAE‐nC1INH) have recently been classified, which occur due to different gene ...
Inmaculada Martinez‐Saguer, Ingo Pragst, Beverley Worrall, Konrad Bork   +3 more
wiley   +1 more source

C1 inhibitor deficient hereditary angioedema is related to endothelial dysfunction in young adult and middle‐aged patients

Clinical and Translational Allergy, Volume 15, Issue 6, June 2025.
Abstract Background Hereditary angioedema (HAE) is a rare, autosomal dominantly inherited disease characterised by mucocutaneous oedema attacks. Vasoactive mediators and the endothelium play an important role in the pathogenesis of HAE. We aimed to evaluate the endothelial dysfunction in HAE. Methods The study included 35 C1 inhibitor deficient (C1‐INH)
Gokce Gul Atay Sensoy, Derya Baykız, İlkim Deniz Toprak, Deniz Eyice Karabacak, Erdem Bektas, Derya Unal, Aslı Gelincik, Semra Demir   +7 more
wiley   +1 more source

Quantitative Proteome Reveals Variation in the Condition Factor of Sea Urchin Strongylocentrotus nudus during the Fishing Season Using an iTRAQ-based Approach

Marine Drugs, 2019
To investigate the variation in the condition factor of the sea urchin Strongylocentrotus nudus (S. nudus), gonads were collected in May (MAY), June (JUN), and July (JUL), at the beginning (AUG-b) and end of August (AUG-e).
Wen-Hui Shang, Jia-Run Han, Jia-Nan Yan, Yi-Nan Du, Yun-Sheng Xu, Chang-Feng Xue, Tie-Tao Zhang, Hai-Tao Wu, Bei-Wei Zhu   +8 more
doaj   +1 more source