Results 51 to 60 of about 1,603,424 (366)
FOXO transcription factor family in cancer and metastasis [PDF]
, 2020 Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting development, metabolism, stem cell maintenance and longevity. They have also been increasingly recognised as tumour suppressors through their ability to regulate
Lam, Eric, Jiramongkol, Yannasittha
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Macrophage Diversity Enhances Tumor Progression and Metastasis
Cell, 2010 There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation they create an inflammatory environment that is mutagenic and which promotes growth.
Binzhi Qian, J. Pollard
semanticscholar +1 more source
Anti-S100A4 Antibody Suppresses Metastasis Formation by Blocking Stroma Cell Invasion
Neoplasia: An International Journal for Oncology Research, 2012 The small Ca-binding protein, S100A4, has a well-established metastasis-promoting activity. Moreover, its expression is tightly correlated with poor prognosis in patients with numerous types of cancer.
Jörg Klingelhöfer +6 more
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Clinical Cancer Research, 2007 In this issue of Clinical Cancer Research , Rofstad et al. ([1][1]) report on the significance of chronic (diffusion-limited) and acute (fluctuating or perfusion-limited) hypoxia in D-12 and R-18 human melanoma xenografts on the development of metastatic disease.
Naz, Chaudary, Richard P, Hill
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Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition [PDF]
, 2013 Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastatic ...
Adam I. Marcus +39 more
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Colorectal Liver Metastasis: Can Cytokines Make the Difference? [PDF]
, 2023 Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide. Metastasis is the prime driver of CRC-related mortality, and the liver is the organ most frequently involved.
Gianluigi Giannelli +2 more
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The impact of VEGF on cancer metastasis and systemic disease.
Seminars in Cancer Biology, 2022 Metastasis is the leading cause of cancer-associated mortality and the underlying mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures are essential structures for mediating distal metastasis.
Yunlong Yang, Yihai Cao
semanticscholar +1 more source
PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment
Frontiers in Immunology, 2020 Background and AimsPyruvate kinase M2 (PKM2) is an essential regulator of the Warburg effect, but its biological function promoting immune escape of hepatocellular carcinoma (HCC) is unclear.MethodsGEPIA web tool and immunohistochemistry (IHC) analysis ...
Tian-En Li +14 more
doaj +1 more source
Neutrophils in cancer carcinogenesis and metastasis
Journal of Hematology & Oncology, 2021 In recent years, neutrophils have attracted increasing attention because of their cancer-promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic indicator for patients with cancer.
Shumin Xiong, Liaoliao Dong, Lin Cheng
semanticscholar +1 more source
Mechanisms of metastasis [PDF]
Breast Cancer Research, 2008 Metastasis is an enormously complex process that remains to be a major problem in the management of cancer. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of the primary tumor makes the metastatic process even more complex.
Hunter, Kent W +2 more
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