Results 31 to 40 of about 1,603,424 (366)

Evolution from small molecule to nano-drug delivery systems: An emerging approach for cancer therapy of ursolic acid

Asian Journal of Pharmaceutical Sciences, 2020
Ursolic acid (UA), a natural pentacyclic triterpenoid, possesses widespread biological and pharmacological activities. However, drawbacks such as low bioavailability, poor targeting and rapid metabolism greatly hinder its further clinical application ...
Jingwei Shao, Yifan Fang, Ruirui Zhao, Fangmin Chen, Mingyue Yang, Jiali Jiang, Zixuan Chen, Xiaotian Yuan, Lee Jia   +8 more
doaj   +1 more source

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

Nature Communications, 2021
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang   +13 more
doaj   +1 more source

Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis

Journal of Bone Oncology, 2019
Bone metastasis of cancer can be a result from systemic blood spreading or vertebral venous plexus spreading. Systemic blood pathway induced bone metastasis can happen in any bone in the body since the spreading is considered to be random. However, it remains unknown whether there is any pattern of vertebral venous plexus related bone metastasis.
Mingyu Zhu, Xin Liu, Yuan Qu, Silong Hu, Yingjian Zhang, Wentao Li, Xiaoyan Zhou, Huijuan Yang, Liangping Zhou, Qifeng Wang, Yifeng Hou, Yong Chen, Yanli Wang, Yaohui Wang, Zhongwu Lu, Zhiguo Luo, Xichun Hu   +16 more
openaire   +3 more sources

Non-Coding RNAs of Extracellular Vesicles: Key Players in Organ-Specific Metastasis and Clinical Implications [PDF]

, 2022
Extracellular vesicles (EVs) are heterogeneous membrane-encapsulated vesicles released by most cells. They act as multifunctional regulators of intercellular communication by delivering bioactive molecules, including non-coding RNAs (ncRNAs).
Liu, Yu Xuan, Yu Xuan Liu, Zhaowu Ma, Xiao-Ping Tan, Cai-Hua Zhang, Qian Jiang, Tan, Xiao-Ping, Li, Du, Lingzhi Wang, Xu, Yan, Zhang, Cai-Hua, Li, Zhi-Yuan, Wang, Lingzhi, Ma, Zhaowu, Zhi-Yuan Li, Jiang, Qian, Du Li, Yan Xu   +17 more
core   +1 more source

EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS

Cell, 2017
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology.
Arthur W. Lambert, D. Pattabiraman, R. Weinberg   +2 more
semanticscholar   +1 more source

Breast cancer metastasis to the stomach [PDF]

, 2019
Aim: This study focuses on the stomach as an unusual but not rare site of metastasis of breast cancer. Methods: We performed a literature search on gastric metastasis from breast cancer searching for reviews from 2000 to 2018 and case reports from 2013
Rampini, Alessia, Antolino, Laura, Aurello, Paolo, Silvia Cardella, Paolo Aurello, Valabrega, Stefano, Alessia Rampini, Giovanni Ramacciato, Giuseppe Nigri, Cardella, Silvia, Francesco D'Angelo, Stefano Valabrega, D'Angelo, Francesco, Laura Antolino, Ramacciato, Giovanni, Nigri, Giuseppe   +15 more
core   +1 more source

The Potential Effect of General Anesthetics in Cancer Surgery: Meta-Analysis of Postoperative Metastasis and Inflammatory Cytokines [PDF]

, 2023
Metastasis or recurrence following curative surgery is the main indicator of tumor progress and is the main cause of patient death. For more than three decades, the potential for general anesthesia to affect cancer outcomes has been a subject of concern ...
Ru Li, Zhaosheng Jin, Jun Lin, James P. Dilger, Hengrui Liu, Qiuyue Liu, Mousumi Beto Mukherjee, Kevin Lin   +7 more
core   +1 more source

CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis

Nature Communications, 2022
Macrophage-mediated immune suppression contributes to poor outcome in liver metastasis. Here the authors show that CD36-expressing metastasis associated macrophages engulf tumor cell-derived extracellular vesicles enriched in long-chain fatty acids ...
Ping Yang, H. Qin, Yiyu Li, Anhua Xiao, Enze Zheng, H. Zeng, Chunxiao Su, Xiaoqing Luo, Qiannan Lu, Meng Liao, Lei Zhao, Li Wei, Z. Varghese, J. Moorhead, Yaxi Chen, X. Ruan   +15 more
semanticscholar   +1 more source

Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib

Journal of Experimental & Clinical Cancer Research, 2019
Background Sorafenib is approved as a standard therapy for advanced hepatocellular carcinoma (HCC), but its clinical application is limited due to moderate therapeutic efficacy and high incidence of acquired resistance resulted from elevated levels of ...
Ning Zheng, Weiqun Liu, Bifei Li, Huifang Nie, Jian Liu, Yunlong Cheng, Jichuang Wang, Haiyan Dong, Lee Jia   +8 more
doaj   +1 more source

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

Cell, 2022
For many solid malignancies, lymph node (LN) involvement represents a harbinger of distant metastatic disease and therefore an important prognostic factor.
Nathan E. Reticker-Flynn, Weiruo Zhang, Julia A. Belk, P. Basto, N. Escalante, G. Pilarowski, Alborz Bejnood, M. Martins, Justin A. Kenkel, I. Linde, Sreya Bagchi, Robert Yuan, Serena Chang, M. Spitzer, Y. Carmi, Jiahan Cheng, Lorna Tolentino, Okmi Choi, N. Wu, C. Kong, A. Gentles, J. Sunwoo, Ansuman T. Satpathy, S. Plevritis, E. Engleman   +24 more
semanticscholar   +1 more source