Results 11 to 20 of about 877,036 (219)

Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

Nature Communications, 2019
Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate ...
Xiaodong Xie, Huifang Nie, Yu Zhou, Shu Lian, Hao Mei, Yusheng Lu, Haiyan Dong, Fengqiao Li, Tao Li, Bifei Li, Jie Wang, Min Lin, Chaihung Wang, Jingwei Shao, Yu Gao, Jianming Chen, Fangwei Xie, Lee Jia   +17 more
doaj   +1 more source

Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib

Journal of Experimental & Clinical Cancer Research, 2019
Background Sorafenib is approved as a standard therapy for advanced hepatocellular carcinoma (HCC), but its clinical application is limited due to moderate therapeutic efficacy and high incidence of acquired resistance resulted from elevated levels of ...
Ning Zheng, Weiqun Liu, Bifei Li, Huifang Nie, Jian Liu, Yunlong Cheng, Jichuang Wang, Haiyan Dong, Lee Jia   +8 more
doaj   +1 more source

Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy

STAR Protocols, 2023
Summary: Organotypic brain cultures are short-term assays that phenotypically and functionally recapitulate brain metastatic cells in vivo. Here, we present a protocol to generate murine organotypic brain cultures for drug screening.
Lucía Zhu, Lauritz Miarka, Patricia Baena, María Perea-García, Manuel Valiente   +4 more
doaj   +1 more source

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

Nature Communications, 2017
The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific.
Martin Teichert, Laura Milde, Annegret Holm, Laura Stanicek, Nicolas Gengenbacher, Soniya Savant, Tina Ruckdeschel, Zulfiyya Hasanov, Kshitij Srivastava, Junhao Hu, Stella Hertel, Arne Bartol, Katharina Schlereth, Hellmut G. Augustin   +13 more
doaj   +1 more source

Anti-S100A4 Antibody Suppresses Metastasis Formation by Blocking Stroma Cell Invasion

Neoplasia: An International Journal for Oncology Research, 2012
The small Ca-binding protein, S100A4, has a well-established metastasis-promoting activity. Moreover, its expression is tightly correlated with poor prognosis in patients with numerous types of cancer.
Jörg Klingelhöfer, Birgitte Grum-Schwensen, Mette K. Beck, Rikke Stagaard Petersen Knudsen, Mariam Grigorian, Eugene Lukanidin, Noona Ambartsumian   +6 more
doaj   +1 more source

PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment

Frontiers in Immunology, 2020
Background and AimsPyruvate kinase M2 (PKM2) is an essential regulator of the Warburg effect, but its biological function promoting immune escape of hepatocellular carcinoma (HCC) is unclear.MethodsGEPIA web tool and immunohistochemistry (IHC) analysis ...
Tian-En Li, Shun Wang, Xiao-Tian Shen, Ze Zhang, Mo Chen, Hao Wang, Ying Zhu, Da Xu, Bei-Yuan Hu, Ran Wei, Yan Zheng, Qiong-Zhu Dong, Qiong-Zhu Dong, Lun-Xiu Qin, Lun-Xiu Qin   +14 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Focal adhesion assembly and cell migration require myoferlin in PDAC cell lines

Scientific Reports
Pancreatic ductal adenocarcinoma (PDAC) has a dire prognosis due to late diagnosis and ineffective treatments. Myoferlin, a transmembrane protein, is overexpressed in PDAC and correlates with poor patient survival, making it a potential therapeutic ...
Charlotte Gullo, Emilie Laverdeur, Manon Dancre, Raphaël Peiffer, Yasmine Boumahd, Ferman Agirman, Naïma Malouhjamoum, Laury Désiront, Marc Thiry, Gilles Rademaker, Akeila Bellahcène, Olivier Peulen   +11 more
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Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Targeting cellular senescence to combat cancer and ageing

Molecular Oncology, 2022
Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth ...
Chen Wang, Xue Hao, Rugang Zhang
doaj   +1 more source