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The Immunometabolism Choreography [PDF]
Cell Metabolism, 2017 At Cell Metabolism, we often banter that “all roads lead to metabolism.” Over the years, we have witnessed the spectacular growth and integration of the metabolism field with other disciplines such as cancer biology, microbiology, and neurobiology.
Nikla, Emambokus +3 more
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Immunometabolism Modulation in Therapy [PDF]
Biomedicines, 2021 The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importance on immune system cells. Enhanced understanding of the molecular bases that give rise to alterations of
Ezequiel Monferrer +10 more
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Focus on Immunometabolism [PDF]
Cell Metabolism, 2013 Biology has surprising twists and turns. Immunology and metabolism, two disciplines that had evolved somewhat in parallel, have meandered back, intersecting to create the burgeoning field of immunometabolism. The past decades have seen a striking increase in obesity together with type 2 diabetes. As researchers tackle this “large” problem from numerous
Granger, Anne, Emambokus, Nikla
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Signaling networks in immunometabolism [PDF]
Cell Research, 2020 Abstract Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine signals coordinately dictate specific signaling networks that trigger the activation and functional programming of T cells.
Jordy Saravia +4 more
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Loneliness: An Immunometabolic Syndrome [PDF]
International Journal of Environmental Research and Public Health, 2021 Loneliness has been defined as an agonizing encounter, experienced when the need for human intimacy is not met adequately, or when a person’s social network does not match their preference, either in number or attributes. This definition helps us realize that the cause of loneliness is not merely being alone, but rather not being in the company we ...
Homa Pourriyahi +3 more
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Systems-based approaches to study immunometabolism. [PDF]
, 2022 Technical advances at the interface of biology and computation, such as single-cell RNA-sequencing (scRNA-seq), reveal new layers of complexity in cellular systems.
Purohit, Vinee +3 more
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Obesity: An Immunometabolic Perspective [PDF]
Frontiers in Endocrinology, 2016 Obesity, characterized by chronic activation of inflammatory pathways, is a critical factor contributing to insulin resistance (IR) and type 2 diabetes (T2D). Free fatty acids (FFAs) are increased in obesity and are implicated as proximate causes of IR and induction of inflammatory signaling in adipose, liver, muscle, and pancreas.
Indrani Ray +3 more
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Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2018 [PDF]
, 2019 Immunometabolism: Molecular mechanisms, diseases, and therapies ...
José C. Rosa +14 more
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Scientific Reports, 2023 Lameness is a common condition in dairy cattle caused by infectious or noninfectious agents. Joint lesions are the second most common cause of lameness and can be diagnosed in association with the presentation of digit injuries.
Carolina Manosalva +8 more
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A guide to immunometabolism for immunologists [PDF]
Nature Reviews Immunology, 2016 In recent years a substantial number of findings have been made in the area of immunometabolism, by which we mean the changes in intracellular metabolic pathways in immune cells that alter their function. Here, we provide a brief refresher course on six of the major metabolic pathways involved (specifically, glycolysis, the tricarboxylic acid (TCA ...
Luke A. J. O'Neill +2 more
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