Results 41 to 50 of about 15,033 (230)
Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence
Frontiers in Immunology, 2021 It is well known that aging is associated with dysregulated metabolism. This is seen both in terms of systemic metabolism, as well as at the cellular level with clear mitochondrial dysfunction.
Dominique E. Martin +3 more
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The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration [PDF]
, 2019 Macrophages are crucial for tissue homeostasis. Based on their activation, they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro-inflammatory cytokines, reactive oxygen species (ROS), and nitric oxide (NO).
Alessio Torcinaro +13 more
core +1 more source
Immunometabolism in rheumatoid arthritis [PDF]
Immunological Medicine, 2018 Recent studies have revealed a relationship between cellular metabolism and cell function in immune cells. Cellular metabolism not only provides supplemental ATP, but also supports dynamic changes in cell proliferation and differentiation. For example, T cells exhibit subset-specific metabolic profiles, and require certain types of metabolism for their
Okano, Takaichi +4 more
openaire +2 more sources
Immunometabolism at the Heart of Cardiovascular Disease
JACC: Basic to Translational Science, 2023 Summary: Immune cell function among the myocardium, now more than ever, is appreciated to regulate cardiac function and pathophysiology. This is the case for both innate immunity, which includes neutrophils, monocytes, dendritic cells, and macrophages ...
Matthew DeBerge, PhD +3 more
doaj +1 more source
The importance of methionine metabolism
eLife, 2019 T helper cells import the amino acid methionine to synthesize new proteins and to provide the methyl groups needed for the methylation of RNA and DNA that drives T cell proliferation and differentiation.
Ramon I Klein Geltink, Erika L Pearce
doaj +1 more source
Bone resorption: supporting immunometabolism [PDF]
Biology Letters, 2018 Activation of the immune system is associated with an increase in the breakdown of various peripheral tissues, including bone. Despite the widely appreciated role of inflammatory mediators in promoting bone resorption, the functional value behind this process is not completely understood.
Gustav van Niekerk +2 more
openaire +2 more sources
Reciprocal Inhibition of Adiponectin and Innate Lung Immune Responses to Chitin and Aspergillus fumigatus [PDF]
, 2019 Chitin is a structural biopolymer found in numerous organisms, including pathogenic fungi, and recognized as an immune-stimulating pathogen associated molecular pattern by pattern recognition molecules of the host immune system.
Amarsaikhan, Nansalmaa +6 more
core +4 more sources
Immunometabolism in Caenorhabditis elegans
PLOS Pathogens, 2020 Here, we discuss 5 concepts that have emerged in studies of metabolic and immune interactions in C. elegans. The major emerging theme is that the immune response and the ability to survive pathogen infection is heavily influenced by pathogen-induced changes in host metabolism.
Sarah M. Anderson, Read Pukkila-Worley
openaire +5 more sources
Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14+CD16− Monocytes
Frontiers in Immunology, 2019 Monocytes in humans consist of 3 subsets; CD14+CD16− (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation.
Man K. S. Lee +16 more
doaj +1 more source
Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses
eLife, 2020 Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses.
Jessica F Walls +6 more
doaj +1 more source