Results 41 to 50 of about 10,784 (232)

Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

eLife, 2020
Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses.
Jessica F Walls, Jeff J Subleski, Erika M Palmieri, Marieli Gonzalez-Cotto, Clair M Gardiner, Daniel W McVicar, David K Finlay   +6 more
doaj   +1 more source

Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14+CD16− Monocytes

Frontiers in Immunology, 2019
Monocytes in humans consist of 3 subsets; CD14+CD16− (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation.
Man K. S. Lee, Man K. S. Lee, Annas Al-Sharea, Annas Al-Sharea, Waled A. Shihata, Camilla Bertuzzo Veiga, Olivia D. Cooney, Andrew J. Fleetwood, Andrew J. Fleetwood, Michelle C. Flynn, Ellen Claeson, Clovis S. Palmer, Graeme I. Lancaster, Darren C. Henstridge, John A. Hamilton, John A. Hamilton, Andrew J. Murphy   +16 more
doaj   +1 more source

Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells

Angewandte Chemie, EarlyView.
Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda, Graham A. Heieis, Laura Bogue Edgerton, Kristine Bertheussen, Diana Torres‐García, Marouane el Boujadayni, Kas Steuten, Jeroen M. Punt, Wouter P. F. Driever, Connor Corrigan, Xinyuan Wang, Bart Everts, David Finlay, Mario van der Stelt, Sander I. van Kasteren   +14 more
wiley   +2 more sources

SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization

Materials Today Bio, 2023
Cardiovascular disease remains the leading cause of death and morbidity worldwide. Inflammatory responses after percutaneous coronary intervention led to neoathrosclerosis and in-stent restenosis and thus increase the risk of adverse clinical outcomes ...
Yuanyuan Cui, Xiaomei Jiang, Maozhu Yang, Yinglin Yuan, Zili Zhou, Xiang Gao, Guiqing Jia, Lvzhou Cao, Danni Li, Yanshuang Zhao, Xin Zhang, Gaoping Zhao   +11 more
doaj   +1 more source

Immunometabolism disorders: Pharmacologic and nonpharmacologic approaches

, 2020
Exercise and Immunometabolism Research Group Department of Physical Education Universidade Estadual Paulista (UNESP)Department of Cell and Developmental Biology Institute of Biomedical Sciences University of São Paulo (USP)Exercise and Immunometabolism ...
Rosa-Neto, J. C., Lira, F. S. [UNESP]
core   +1 more source

Immunometabolism changes in fibrosis: from mechanisms to therapeutic strategies [PDF]

, 2023
Immune cells are essential for initiating and developing the fibrotic process by releasing cytokines and growth factors that activate fibroblasts and promote extracellular matrix deposition. Immunometabolism describes how metabolic alterations affect the
Xingyu Chen, Lixiang Feng, Shaojiang Zheng, Na Xie, Xiaodian Zhang, Yujing Huang   +5 more
core   +1 more source

Muscle-Organ Crosstalk:Focus on Immunometabolism

, 2020
Skeletal muscle secretes several hundred myokines that facilitate communication from muscle to other organs, such as, adipose tissue, pancreas, liver, gut, and brain.
Bay, Marie Lund, Pedersen, Bente Klarlund   +1 more
core   +1 more source

Immunometabolism in Caenorhabditis elegans

PLOS Pathogens, 2020
Here, we discuss 5 concepts that have emerged in studies of metabolic and immune interactions in C. elegans. The major emerging theme is that the immune response and the ability to survive pathogen infection is heavily influenced by pathogen-induced changes in host metabolism.
Sarah M. Anderson, Read Pukkila-Worley
openaire   +5 more sources

Crosstalk Between Metabolism and Immune Activity Reveals Four Subtypes With Therapeutic Implications in Clear Cell Renal Cell Carcinoma

Frontiers in Immunology, 2022
Clear cell renal cell carcinoma (ccRCC) is characterized by metabolic dysregulation and distinct immunological signatures. The interplay between metabolic and immune processes in the tumor microenvironment (TME) causes the complexity and heterogeneity of
Yi Wang, Yi Wang, Xin-De Zheng, Xin-De Zheng, Gui-Qi Zhu, Gui-Qi Zhu, Na Li, Na Li, Chang-Wu Zhou, Chang-Wu Zhou, Chun Yang, Chun Yang, Meng-Su Zeng, Meng-Su Zeng   +13 more
doaj   +1 more source

Tissue Immunometabolism in Autoimmunity. [PDF]

Eur J Immunol
ABSTRACT Autoimmunity causes damage to organs targeted by the effector function of the immune response. The dynamics of autoimmunity in human peripheral tissues are not well understood due to the limited access to tissue samples. As cellular metabolism controls immune function, studying the crosstalk between the environment and cells ...
Villa M.
europepmc   +3 more sources