Results 61 to 70 of about 10,784 (232)

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Immunometabolism in type 2 diabetes mellitus:tissue-specific interactions [PDF]

, 2023
The immune system is frequently described in the context of its protective function against infections and its role in the development of autoimmunity. For more than a decade, the interactions between the immune system and metabolic processes have been ...
Marzec, Michal, Pinheiro-Machado, Erika; id_orcid, Marzec, Michal Tomasz, Gurgul-Convey, Ewa, Convey, Ewa Gurgul-, Pinheiro-Machado, Erika   +5 more
core   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

Immunometabolism and HIV-1 pathogenesis: food for thought

, 2021
International audienceAntiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life. Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite treatment. There is, therefore, an urgent need to
Sáez-Cirión, Asier, Sereti, Irini
core   +1 more source

Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid

Frontiers in Immunology, 2023
In obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing a key role in the development of chronic inflammation and Type 2 diabetes.
Margaud Iovino, Megan Colonval, Chloé Wilkin, Laurent L’homme, Cédric Lassence, Manon Campas, Olivier Peulen, Pascal de Tullio, Jacques Piette, Sylvie Legrand-Poels   +9 more
doaj   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Immunometabolism and the kinome peptide array: A new perspective and tool for the study of gut health

Frontiers in Veterinary Science, 2015
Immunometabolism is a relatively new research perspective, focusing on both metabolism and immunology and the cross-talk between these biological processes.
Ryan J Arsenault, Michael eKogut
doaj   +1 more source

The Investigations of NPS Modulated Immunity and Immunometabolism

, 2021
Cancers remain in the top noncommunicable diseases responsible for premature mortality. The heterogeneity among cancers and within tumors makes treating them ever more challenging.
Ruedlinger, Brittney Leigh
core   +1 more source

Exercise training alters circadian clock dynamics in cancer‐bearing male mice

Physiological Reports
Alterations in circadian timing mechanisms are increasingly recognized as contributing to tumor initiation and progression. Moreover, evidence indicates that malignant cells can interfere with the expression and synchronization of core clock genes ...
Loreana Sanches Silveira, Edson Alves deLima Junior, José Cesar Rosa Neto, Alexandre Abilio deSouza Teixeira   +3 more
doaj   +1 more source

MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells

Scientific Reports, 2020
MZB1 is an endoplasmic reticulum (ER)-resident protein that plays an important role in the humoral immune response by enhancing the interaction of the μ immunoglobulin (Ig) heavy chain with the chaperone GRP94 and by augmenting the secretion of IgM. Here,
Tanya Kapoor, Mauro Corrado, Erika L. Pearce, Edward J. Pearce, Rudolf Grosschedl   +4 more
doaj   +1 more source