Results 61 to 70 of about 15,033 (230)

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]

, 2018
Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid, Blanco, Daniel Bastardo, Chen, Wenan, Chen, Xiang, Cheng, Changde, Chi, Hongbo, Dash, Pradyot, Dhungana, Yogesh, Easton, John, Guo, Xi-Zhi J., Kc, Anil, Neale, Geoffrey, Rosencrance, Celeste, Thomas, Paul G., Yang, Kai   +14 more
core   +1 more source

Immunometabolism of Leishmania granulomas [PDF]

Immunology & Cell Biology, 2020
AbstractLeishmania are parasitic protists that cause a spectrum of diseases in humans characterized by the formation of granulomatous lesions in the skin or other tissues, such as liver and spleen. The extent to which Leishmania granulomas constrain or promote parasite growth is critically dependent on the host T‐helper type 1/T‐helper type 2 immune ...
Eleanor C Saunders, Malcolm J McConville
openaire   +3 more sources

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Phytochemical Targeting of STAT3 Orchestrated Lipid Metabolism in Therapy-Resistant Cancers

Biomolecules, 2020
Lipids are critical for maintaining homeostasis and cellular metabolism. However, the dysregulation of lipid metabolism contributes to the pathogenesis of chronic inflammatory diseases and is a hallmark of several cancer types.
Carmen Tse, Ashleigh Warner, Rufaik Farook, James G Cronin   +3 more
doaj   +1 more source

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. [PDF]

, 2019
Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial ...
Borneman, James, Braun, Jonathan, Bushman, Frederic, Casero, David, Chang, Yu-Ling, Harre, Nicholas, Humphries, Romney, Huttenhower, Curtis, Lewis, James, McGovern, Dermot PB, Miller, Shelley, Rossetti, Maura, Salzman, Nita, Sartor, R Balfour, Simpson, Kenneth W, Stappenbeck, Thaddeus, Sunga, Gemalene, Vlamakis, Hera, Wu, Gary, Xavier, Ramnik   +19 more
core   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Epigenetic Network in Immunometabolic Disease

Advanced Biology, 2023
AbstractAlthough a large amount of data consistently shows that genes affect immunometabolic characteristics and outcomes, epigenetic mechanisms are also heavily implicated. Epigenetic changes, including DNA methylation, histone modification, and noncoding RNA, determine gene activity by altering the accessibility of chromatin to transcription factors.
Geiger, Martin, Gorica, Era, Mohammed, Shafeeq Ahmed, Mongelli, Alessia, Mengozi, Alessandro, Delfine, Valentina, Ruschitzka, Frank, Costantino, Sarah, Paneni, Francesco   +8 more
openaire   +3 more sources

Effects of a workplace gymnastics program on the perception of pain in administrative workers

Discover Public Health
Background Administrative professionals spend most of their time sitting in uncomfortable postures. These factors lead to the emergence of chronic pain, and workplace gymnastics (WG) can be presented as a strategy to minimize these problems.
Letícia Mendes de Morais, Letícia Resende Viegas, David Michel de Oliveira, Mayara Bocchi, Eduardo Vignoto Fernandes   +4 more
doaj   +1 more source

Delphinidin Exerts Immunomodulatory Effects in Canine Neutrophils and Peripheral Blood Mononuclear Cells by Limiting Tissue Damaging Mechanisms and Regulating Cytokine Responses

Animals
Dogs can develop chronic inflammatory diseases that induce progressive tissue damage and illness. Delphinidin is a component of maqui (Aristotelia chilensis) and has anti-inflammatory and antioxidant effects.
Alejandra I. Hidalgo, Macarena Vega, Denisse Maldonado, Stefanie Teuber, Rafael A. Burgos, María A. Hidalgo   +5 more
doaj   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source