Results 61 to 70 of about 12,077 (249)
Macrophage immunometabolism dysregulation and inflammatory disorders.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieMacrophages are innate immune cells which are involved in triggering inflammation. Growing evidence shows that, macrophages respond to intracellular and extracellular cues which makes them adopt either anti-inflammatory or pro-inflammatory functions and ...
Karen Pomeyie +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao +11 more
wiley +1 more source
An Integrated View of Immunometabolism [PDF]
Cell, 2018 The worldwide obesity epidemic has emerged as a major cause of insulin resistance and Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the field of immunometabolism has witnessed many advances in recent years. Here, we review the major features of our current understanding with respect to chronic obesity-related
Lee, Yun Sok +2 more
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Frontiers in Immunology, 2023 Lung macrophages constitute the first line of defense against airborne particles and microbes and are key to maintaining pulmonary immune homeostasis. There is increasing evidence suggesting that macrophages also participate in the pathogenesis of acute ...
Lian Wang +5 more
doaj +1 more source
Advanced Science, EarlyView.Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao +11 more
wiley +1 more source
Immunometabolic control of hematopoiesis
Molecular Aspects of Medicine, 2021 Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is essential for demand-adapted ...
George Hajishengallis +2 more
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Frontiers in Immunology, 2023 In obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing a key role in the development of chronic inflammation and Type 2 diabetes.
Margaud Iovino +9 more
doaj +1 more source
Advanced Science, EarlyView.Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He +9 more
wiley +1 more source
Exercise training alters circadian clock dynamics in cancer‐bearing male mice
Physiological ReportsAlterations in circadian timing mechanisms are increasingly recognized as contributing to tumor initiation and progression. Moreover, evidence indicates that malignant cells can interfere with the expression and synchronization of core clock genes ...
Loreana Sanches Silveira +3 more
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Frontiers in Veterinary Science, 2015 Immunometabolism is a relatively new research perspective, focusing on both metabolism and immunology and the cross-talk between these biological processes.
Ryan J Arsenault, Michael eKogut
doaj +1 more source