Results 71 to 80 of about 12,525 (189)

T cells and their immunometabolism: a novel way to understanding sepsis immunopathogenesis and future therapeutics [PDF]

, 2018
Sepsis has always been considered as a big challenge for pharmaceutical companies in terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves aberrant activation of innate immune cells (i.e.
V. Kumar, Kumar, V.
core   +1 more source

Immunometabolism of Dendritic cells in Porphyromonas Gingivalis-stimulated Hyperglycemic Microenvironment [PDF]

, 2022
Chronic inflammation associated with immune dysregulation is the key mediator to connect periodontitis and diabetes mellitus. These two chronic diseases have a bidirectional relationship to each other. Dendritic cells (DC) have a significant role to link
Yao, Binchen
core   +1 more source

Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications

Molecular Cancer
Epigenomic modifications—such as DNA methylation, histone acetylation, and histone methylation—and their implications in tumorigenesis, progression, and treatment have emerged as a pivotal field in cancer research.
Xiaowen Xie, Weici Liu, Zhiyuan Yuan, Hanqing Chen, Wenjun Mao   +4 more
doaj   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

Daily Consumption of Unprocessed/Minimally Processed Foods and Its Relationship with Serum Phosphorus, CD3+, and CD45+ Cell Counts in People Living with HIV: A Cross-Sectional Descriptive Study

Medical Sciences
Objectives: To investigate the potential associations between the daily consumption of unprocessed/minimally processed foods and serum phosphorus levels, CD3+, and CD45+ cell counts in clinically stable people living with HIV (PLHIV).
Kaila Souza Gomes Carvalho, David Michel de Oliveira, Mayara Bocchi, Fábio Morato de Oliveira, Eduardo Vignoto Fernandes   +4 more
doaj   +1 more source

The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective

Journal of Diabetes Research, 2017
Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions are associated with increased risk for the development of other comorbidities and obesity-related diseases.
Jéssica Aparecida da Silva Pereira, Felipe Corrêa da Silva, Pedro Manoel Mendes de Moraes-Vieira   +2 more
doaj   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Unraveling Diabetic Kidney Disease: The Roles of Mitochondrial Dysfunction and Immunometabolism

Kidney International Reports
Mitochondria are essential for cellular energy production and are implicated in numerous diseases, including diabetic kidney disease (DKD). Current evidence indicates that mitochondrial dysfunction results in alterations in several metabolic pathways ...
Phoom Narongkiatikhun, Ye Ji Choi, Hailey Hampson, Jimmy Gotzamanis, Guanshi Zhang, Daniel H. van Raalte, Ian H. de Boer, Robert G. Nelson, Kalie L. Tommerdahl, Phillip J. McCown, Jenny Kanter, Kumar Sharma, Petter Bjornstad, Pierre Jean Saulnier   +13 more
doaj   +1 more source

Immunometabolism in Tuberculosis

Frontiers in Immunology, 2016
Immunometabolism, the study of the relationship between bioenergetic pathways and specific functions of immune cells, has recently gained increasing appreciation.
Lanbo eShi, Eliseo A Eugenin, Selvakumar eSubbian   +2 more
doaj   +1 more source