Results 71 to 80 of about 10,784 (232)
Role of Lactate in Inflammatory Processes: Friend or Foe
Frontiers in Immunology, 2022 During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely attributed to the presence of lactate by an increase in ...
Carolina Manosalva +8 more
doaj +1 more source
Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications
Barrier Immunity, EarlyView.A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu +9 more
wiley +1 more source
T cells and their immunometabolism: a novel way to understanding sepsis immunopathogenesis and future therapeutics [PDF]
, 2018 Sepsis has always been considered as a big challenge for pharmaceutical companies in terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves aberrant activation of innate immune cells (i.e.
V. Kumar, Kumar, V.
core +1 more source
The immunometabolic roots of aging [PDF]
Current Opinion in ImmunologyAging is one of the greatest risk factors for several chronic diseases and is accompanied by a progressive decline of cellular and organ function. Recent studies have highlighted the changes in metabolism as one of the main drivers of organism dysfunctions during aging and how that strongly deteriorate immune cell performance and function.
Pierpaolo Ginefra +4 more
openaire +2 more sources
eLifeHepatic factors secreted by the liver promote homeostasis and are pivotal for maintaining the liver-gut axis. Bile acid metabolism is one such example wherein, bile acid synthesis occurs in the liver and its biotransformation happens in the intestine ...
Jyotsna +11 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong +15 more
wiley +1 more source
Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance
Interdisciplinary Medicine, EarlyView.This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang +14 more
wiley +1 more source
Immunometabolism in fungal infections:the need to eat to compete [PDF]
, 2020 Immune cells, including macrophages and monocytes, remodel their metabolism and have specific nutritional needs when dealing with microbial pathogens.
Weerasinghe, Harshini, Traven, Ana
core +1 more source
An evolutionary perspective on immunometabolism [PDF]
Science, 2019 Metabolism as a driver of immune response All living organisms need energy and metabolic building blocks to sustain biological processes. Wang et al. review immunometabolism, applying the principles of life history theory.
Andrew Wang +2 more
openaire +2 more sources
Immunometabolism around the clock
, 2021 Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle, providing circadian rhythmicity. An example of a circadian behaviour common to most organisms is the feeding/fasting cycle, which shapes whole-body metabolism ...
Mariana P Cervantes-Silva (11267437) +4 more
core +1 more source