Results 91 to 100 of about 12,525 (189)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, Volume 16, Issue 10, Page 1958-1973, October 2026.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Macrophage Immunometabolism: Where Are We (Going)?

, 2017
A growing number of findings highlight the crucial role of metabolic reprogramming in macrophage activation. Metabolic pathways are closely interconnected and recent literature demonstrates the need for glucose metabolism in anti-inflammatory as well as ...
Menon, Deepthi, O'Neill, Luke A, Jan Van den Bossche, O'Neill, Luke A., Deepthi Menon, Luke A. O’Neill, van den Bossche, Jan   +6 more
core   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Immunometabolism and Exercise: New avenues

, 2017
Immune system and cell metabolism have been interacted constantly, by synthesis and release of immunomodulatory proteins, recognized as cytokines, in order to maintain the body homeostasis.
De Moura Antunes, Barbara [UNESP], Daniela S Inoue, Inoue, Daniela Sayuri [UNESP], Neto, José Cesar Rosa, Barbara MM Antunes, Fabrício E Rossi, Lir, Fábio Santos [UNESP], Fábio S Lira, José Cesar Rosa Neto, Rossi, Fabrício Eduardo [UNESP]   +9 more
core   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

The Growth and Trends in Cancer‐Induced Cachexia Research: A Bibliometric and AI‐Guided Visualization Analysis

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Over the past several decades, advances in basic and clinical research have increasingly established cancer‐induced cachexia as a distinct pathophysiological syndrome that warrants targeted therapeutic approaches alongside conventional anticancer treatments. Despite its high prevalence and substantial impact on morbidity, mortality,
Thomas M. O'Connell, Radhika Gedela, Fabrizio Pin   +2 more
wiley   +1 more source

Acknowledgement to Reviewers of Immunometabolism in 2020

, 2021
The Immunometabolism Editorial Office
core   +1 more source

Metabolic regulation of the immune system in health and diseases: mechanisms and interventions

Signal Transduction and Targeted Therapy
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells.
Tengyue Hu, Chang-Hai Liu, Min Lei, Qingmin Zeng, Li Li, Hong Tang, Nannan Zhang   +6 more
doaj   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

B cell immunometabolism in health and disease

B cells have crucial roles in the initiation and progression of many pathological conditions, and several therapeutic strategies have targeted the function of these cells. The advent of immunometabolism has provided compelling evidence that the metabolic
Pucillo, Carlo Ennio Michele, La Cava, Antonio, Colamatteo, Alessandra, Matarese, Giuseppe, Martinis, Eleonora, Tonon, Silvia   +5 more
core   +1 more source