Results 91 to 100 of about 10,784 (232)

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Raman micro-spectroscopy as a tool to study immunometabolism [PDF]

In the past two decades, immunometabolism has emerged as a crucial field, unraveling the intricate molecular connections between cellular metabolism and immune function across various cell types, tissues, and diseases.
Xu, Jiabao, Morten, Karl J., Morten, Karl J   +2 more
core   +1 more source

Immunometabolism in cancer: basic mechanisms and new targeting strategy

Cell Death Discovery
Maturing immunometabolic research empowers immune regulation novel approaches. Progressive metabolic adaptation of tumor cells permits a thriving tumor microenvironment (TME) in which immune cells always lose the initial killing capacity, which remains ...
Ranran Su, Yingying Shao, Manru Huang, Donghui Liu, Haiyang Yu, Yuling Qiu   +5 more
doaj   +1 more source

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia

The Journal of Physiology, EarlyView.
Abstract figure legend PoWeR training (11.5 weeks of voluntary wheel running with progressively increased resistance) before and during cancer attenuates muscle loss, limits tumour growth, drives a transition toward a more oxidative muscle phenotype (IIB‐to‐IIA shift), downregulates cachexia‐associated pathways and enhances mitochondrial performance in
Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +13 more
wiley   +1 more source

The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective

Journal of Diabetes Research, 2017
Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions are associated with increased risk for the development of other comorbidities and obesity-related diseases.
Jéssica Aparecida da Silva Pereira, Felipe Corrêa da Silva, Pedro Manoel Mendes de Moraes-Vieira   +2 more
doaj   +1 more source

Mesenteric Lymphatic Dysfunction as the Initiating Event in Crohn's Disease: Toward an Outside‐In Paradigm

JCC Plus, Volume 1, Issue 4, July 2026.
Mesenteric lymphatic dysfunction promotes immune cell accumulation and chronic inflammation, leading to creeping fat formation. Progressive activity drives transmural inflammation. ABSTRACT Crohn's disease (CD) has traditionally been explained by an “inside‐out” model, in which disruption of the intestinal mucosal barrier allows luminal bacteria to ...
Takayuki Ogino, Yuki Sekido, Tsunekazu Mizushima, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Norikatsu Miyoshi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi   +9 more
wiley   +1 more source

Macrophage Immunometabolism: Where Are We (Going)?

, 2017
A growing number of findings highlight the crucial role of metabolic reprogramming in macrophage activation. Metabolic pathways are closely interconnected and recent literature demonstrates the need for glucose metabolism in anti-inflammatory as well as ...
Menon, Deepthi, O'Neill, Luke A, Jan Van den Bossche, O'Neill, Luke A., Deepthi Menon, Luke A. O’Neill, van den Bossche, Jan   +6 more
core   +1 more source

Daily Consumption of Unprocessed/Minimally Processed Foods and Its Relationship with Serum Phosphorus, CD3+, and CD45+ Cell Counts in People Living with HIV: A Cross-Sectional Descriptive Study

Medical Sciences
Objectives: To investigate the potential associations between the daily consumption of unprocessed/minimally processed foods and serum phosphorus levels, CD3+, and CD45+ cell counts in clinically stable people living with HIV (PLHIV).
Kaila Souza Gomes Carvalho, David Michel de Oliveira, Mayara Bocchi, Fábio Morato de Oliveira, Eduardo Vignoto Fernandes   +4 more
doaj   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source