Results 101 to 110 of about 15,033 (230)

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Integrating multi-omics and machine learning systematically deciphers cellular heterogeneity and fibrotic regulatory networks in the progression from MASLD to MASH

npj Digital Medicine
The progression from metabolic dysfunction-associated steatotic liver disease (MASLD) to metabolic dysfunction-associated steatohepatitis (MASH) is a critical link leading to cirrhosis and hepatocellular carcinoma.
Weiheng Wen, Zenghui Liu, Wenliang Tan, Yingzheng Tan, Wei Li, Jian Wan, Hongsai Hu, Zhengwu Jiang, Xing Tang, Jing Yang, Jiao Xiao, Xiongjin Tan, Xun Chen, Peili Wu, Yukun Li   +14 more
doaj   +1 more source

Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets [PDF]

, 2019
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.
Antwi-Baffour, Samuel, Inal, Jameel, Jorfi, Samireh, Lange, Sigrun, Malibha-Pinchbeck, Memory, Stratton, Dan   +5 more
core   +5 more sources

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications

Molecular Cancer
Epigenomic modifications—such as DNA methylation, histone acetylation, and histone methylation—and their implications in tumorigenesis, progression, and treatment have emerged as a pivotal field in cancer research.
Xiaowen Xie, Weici Liu, Zhiyuan Yuan, Hanqing Chen, Wenjun Mao   +4 more
doaj   +1 more source

Andrographolide Ameliorates Inflammatory Changes Induced by D-Lactate in Bovine Fibroblast-like Synoviocytes

Animals
During acute ruminal acidosis, the manifestation of aseptic polysynovitis and lameness in cattle has been observed. Evidence suggests that joint inflammation can be attributed to the metabolic alterations induced by D-lactate in fibroblast-like ...
Stefanie Teuber, Carolina Manosalva, Pablo Alarcón, John Quiroga, Diana Pantoja, María Angélica Hidalgo, Gabriel Morán, Rafael Agustín Burgos   +7 more
doaj   +1 more source

Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases

Journal of Lipid Research, 2020
Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells.
Pooranee K. Morgan, Longhou Fang, Graeme I. Lancaster, Andrew J. Murphy   +3 more
doaj   +1 more source

Cocoa procyanidins modulate transcriptional pathways linked to inflammation and metabolism in human dendritic cells [PDF]

, 2018
Foods rich in polyphenols such as procyanidins (PC) have been proposed to have anti-inflammatory properties, and we have previously reported inhibition of lipopolysaccharide (LPS)-induced inflammatory cytokine secretion in human dendritic cells (DCs) by ...
Bak, Bidani, Bitzer, Chang, Choy, Conboy, Da Silva, Denis, Farache, Gea, Gentile, Giordano, Jang, Kambayashi, Kimura, Madrigal-Carballo, Manach, Martinez-Micaelo, Martinez-Micaelo, Midttun, Miyake, Mueller-Harvey, Nathan, O'Neill, Oz, Rahman, Reed, Rios, Schulz, Scott, Stamenkovic, Sung, Thomas, Tusher, Williams, Williams, Yu   +36 more
core   +1 more source

Niacin promotes motor function recovery after spinal cord injury via Hcar2‐dependent microglia immunometabolic regulation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• The activation of the microglial Hcar2 receptor by niacin initiates intracellular signalling that induces metabolic reprogramming. • This metabolic shift is characterized by increased oxidative phosphorylation. Consequently, microglia polarize from a proinflammatory state toward an anti‐inflammatory, reparative phenotype.
Hua Du, Lingnian Zeng, Chan Liu, Huyao Zhou, Xia Wang, Qing Ai, Jinpiao Zhu, Nong Xiao   +7 more
wiley   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source