Results 121 to 130 of about 10,784 (232)
Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics
MedComm, Volume 7, Issue 6, June 2026.This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou +10 more
wiley +1 more source
The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy
Pharmacological ResearchImmunometabolism has received significant interest as a field exploring the dynamic interation between the immune system and metabolic processes. Immune cell activation, proliferation, and function are tightly regulated by metabolism, and metabolic ...
Xin Zhou, Ning-ning Shan
doaj +1 more source
Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 6, June 2026.FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li +10 more
wiley +1 more source
MOESM1 of Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2
, 2018 Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of ...
Timothy Billiar (5767349) +7 more
core +1 more source
Inflammation, Immunity, and Cardiovascular Diseases
Med Research, Volume 2, Issue 2, Page 343-370, June 2026.Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo +8 more
wiley +1 more source
Frontiers in ImmunologyHepatitis B Virus (HBV) infections pose a global public health challenge. Despite extensive research on this disease, the intricate mechanisms underlying persistent HBV infection require further in-depth elucidation.
Zhengmin Wang +4 more
doaj +1 more source
Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi +2 more
wiley +1 more source
, 2022 Chronic inflammation associated with immune dysregulation is the key mediator to connect periodontitis and diabetes mellitus. These two chronic diseases have a bidirectional relationship to each other. Dendritic cells (DC) have a significant role to link
Yao, Binchen
core
HPV vaccination improves immune response in children with respiratory papillomatosis
Scientific ReportsRecurrent respiratory papillomatosis (RRP) is a pathology characterized by the presence of neoplasm in the epithelium of the airways, where the larynx is the main affected organ. The cause of this disease is the low-risk Human Papillomavirus (HPV), where
Miguel A. Prieto-Islas +7 more
doaj +1 more source
eLifeMycobacterium tuberculosis (Mtb) infection of the lungs, besides producing prolonged cough with mucus, also causes progressive fatigue and cachexia with debilitating loss of muscle mass.
Binayak Sarkar +13 more
doaj +1 more source