Results 111 to 120 of about 12,525 (189)

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

Targeting macrophage immunometabolism: dawn in the darkness of sepsis

, 2018
Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates. Advancement in modern medicine and establishment of separate branches of medical science dealing with sepsis research have improved its outcome.
V. Kumar, Kumar, V.
core   +1 more source

Tumor necrosis factor alpha triggers mitochondrial dysfunction and ROS-driven cytokine amplification in bovine fibroblast-like synoviocytes

Frontiers in Veterinary Science
Lameness in dairy cattle, driven by joint inflammation, involves fibroblast-like synoviocytes (FLS) that produce inflammatory mediators and reactive oxygen species (ROS).
Natalia Andrea Godoy, Jan Gallastegui, Gabriela Velásquez, Stefanie Teuber, Sebastian Brauchi, John Quiroga, Pablo Alarcón, Gabriel Moran, María Angélica Hidalgo, Juan Hancke, Rafael Agustín Burgos   +10 more
doaj   +1 more source

Disulfiram Attenuates Adenine‐Induced Renal Fibrosis by Modulating Inflammatory and Immunometabolic Responses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Chronic kidney disease (CKD) is characterized by persistent inflammation that drives progressive renal injury and fibrosis. In this study, we demonstrate that disulfiram markedly attenuates kidney injury and fibrosis in adenine‐induced nephropathy by suppressing innate immune responses and reducing DNA damage and cellular senescence.
Saori Kin, Yuji Oe, Shun Ishigaki, Ichiro Fujio, Mariko Miyazaki, Tetsuhiro Tanaka   +5 more
wiley   +1 more source

MOESM1 of Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2

, 2018
Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of ...
Timothy Billiar (5767349), Daolin Tang (156143), Min Xie (273315), Lizhi Cao (562709), Rui Kang (562707), Haichao Wang (36078), Zhaoxia Zhang (3714328), Wenjun Deng (837501)   +7 more
core   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

The novel mechanism facilitating chronic hepatitis B infection: immunometabolism and epigenetic modification reprogramming

Frontiers in Immunology
Hepatitis B Virus (HBV) infections pose a global public health challenge. Despite extensive research on this disease, the intricate mechanisms underlying persistent HBV infection require further in-depth elucidation.
Zhengmin Wang, Nan Liu, Yang Yang, Zhengkun Tu, Zhengkun Tu   +4 more
doaj   +1 more source

Immunometabolism in atherosclerosis:a new understanding of an old disease [PDF]

Atherosclerosis, a chronic inflammatory condition, remains a leading cause of death globally, necessitating innovative approaches to target pro-atherogenic pathways.
Certo, Michelangelo; id_orcid, Mauro, Claudio; id_orcid, Rahimzadeh, Mahsa   +2 more
core   +1 more source

Unraveling the immunometabolism puzzle: Deciphering systemic sclerosis pathogenesis

The article delves into the pathogenesis of systemic sclerosis (SSc) with an emphasis on immunometabolism dysfunctions. SSc is a complex autoimmune connective tissue disorder with skin and organ fibrosis manifestation, vasculopathy, and immune ...
Maryam Masoumi, Ali Saeedi-Boroujeni, Jafar Karami, Hossein Khorramdelazad, Ali Bayat Bodaghi, Erfan Ebadi, Sheyda Houshmandfar   +6 more
core   +1 more source

Immunometabolism and rheumatic disease-advancing targeted therapies. [PDF]

EULAR Rheumatol Open
Boothby MR.
europepmc   +1 more source