Results 111 to 120 of about 15,033 (230)

Immunometabolism in cancer: basic mechanisms and new targeting strategy

Cell Death Discovery
Maturing immunometabolic research empowers immune regulation novel approaches. Progressive metabolic adaptation of tumor cells permits a thriving tumor microenvironment (TME) in which immune cells always lose the initial killing capacity, which remains ...
Ranran Su, Yingying Shao, Manru Huang, Donghui Liu, Haiyang Yu, Yuling Qiu   +5 more
doaj   +1 more source

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao   +10 more
wiley   +1 more source

The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective

Journal of Diabetes Research, 2017
Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions are associated with increased risk for the development of other comorbidities and obesity-related diseases.
Jéssica Aparecida da Silva Pereira, Felipe Corrêa da Silva, Pedro Manoel Mendes de Moraes-Vieira   +2 more
doaj   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, Volume 13, Issue 21, 13 April 2026.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

TREM1/3 deficiency impairs tissue repair after acute kidney injury and mitochondrial metabolic flexibility in tubular epithelial cells [PDF]

, 2019
Long-term sequelae of acute kidney injury (AKI) are associated with incomplete recovery of renal function and the development of chronic kidney disease (CKD), which can be mediated by aberrant innate immune activation, mitochondrial pathology, and ...
Borrelli, Cristiana, Butter, Loes M, Claessen, Nike, Colonna, Marco, Dessing, Mark C, Florquin, Sandrine, Leemans, Jaklien C, Rampanelli, Elena, Scantlebery, Angelique M.L, Soriani, Alessandra, Tammaro, Alessandra   +10 more
core   +2 more sources

Unraveling Diabetic Kidney Disease: The Roles of Mitochondrial Dysfunction and Immunometabolism

Kidney International Reports
Mitochondria are essential for cellular energy production and are implicated in numerous diseases, including diabetic kidney disease (DKD). Current evidence indicates that mitochondrial dysfunction results in alterations in several metabolic pathways ...
Phoom Narongkiatikhun, Ye Ji Choi, Hailey Hampson, Jimmy Gotzamanis, Guanshi Zhang, Daniel H. van Raalte, Ian H. de Boer, Robert G. Nelson, Kalie L. Tommerdahl, Phillip J. McCown, Jenny Kanter, Kumar Sharma, Petter Bjornstad, Pierre Jean Saulnier   +13 more
doaj   +1 more source

The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease [PDF]

, 2019
Microglia are key players in the pathology of Alzheimer’s disease (AD), driving chronic inflammation, oxidative stress, and the altered metabolism seen in the brains of patients.
Wickstead, E., Wickstead, E.
core  

Daily Consumption of Unprocessed/Minimally Processed Foods and Its Relationship with Serum Phosphorus, CD3+, and CD45+ Cell Counts in People Living with HIV: A Cross-Sectional Descriptive Study

Medical Sciences
Objectives: To investigate the potential associations between the daily consumption of unprocessed/minimally processed foods and serum phosphorus levels, CD3+, and CD45+ cell counts in clinically stable people living with HIV (PLHIV).
Kaila Souza Gomes Carvalho, David Michel de Oliveira, Mayara Bocchi, Fábio Morato de Oliveira, Eduardo Vignoto Fernandes   +4 more
doaj   +1 more source

Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages [PDF]

, 2016
Bacterial lipopolysaccharide induces changes in intracellular NAD+ levels in a pro-inflammatory, but not an anti-inflammatory, macrophage model that are correlated with the release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α).
Abbas Jawad Al-Shabany, Al-Abady, Alan John Moody, Andrew David Foey, Bieganowski, Bruzzone, Daigneault, Dietl, Fedele, Ferrero, Finlay, Galvan-Pena, Holen, Horwitt, Hotamisligil, Howard, Iqbal, Leonardo, Livak, Maciver, Magni, Magni, Murray, Park, Remer, Revollo, Richard Andrew Billington, Riebel, Rongvaux, Schertzer, Schilling, Schwende, Shubinsky, Sutherland, Tavakoli, Van Gool   +35 more
core   +2 more sources

Short-Term High- and Moderate-Intensity Training Modifies Inflammatory and Metabolic Factors in Response to Acute Exercise

Frontiers in Physiology, 2017
Purpose: To compare the acute and chronic effects of high intensity intermittent training (HIIT) and steady state training (SST) on the metabolic profile and inflammatory response in physically active men.Methods: Thirty recreationally active men were ...
Fabio Santos Lira, Thaislaine dos Santos, Renan Santos Caldeira, Daniela S. Inoue, Valéria L. G. Panissa, Carolina Cabral-Santos, Eduardo Z. Campos, Bruno Rodrigues, Paula A. Monteiro   +8 more
doaj   +1 more source